Recombinant Human Citrullinated GFAP Protein, His tagged

• Cat.No.: GFAP-03H
• Product Overview: Recombinant N-terminal histidine-tagged GFAP expressed in E. coli, citrullinated with recombinant human PAD2

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 2-432 aa
• Description: This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Form: 10 mM Tris, pH 7.4
• Molecular Mass: 51.9 kDa
• Purity: ≥85% estimated by SDS-PAGE
• Storage: At -80 centigrade. Stability: ≥ 1 year
• Shipping: Dry ice in continental US; may vary elsewhere
• Reference: 1. Hol, E.M., and Capetanaki, Y. Type III intermediate filaments desmin, glial fibrillary acidic protein (GFAP), vimentin, and peripherin. Cold Spring Harb. Perspect. Biol. 9(12), a021642 (2017). 2. Ishigami, A., Masutomi, H., Handa, S., et al. Mass spectrometric identification of citrullination sites and immunohistochemical detection of citrullinated glial fibrillary acidic protein in Alzheimer’s disease brains. J. Neurosci. Res. 93(11), 1664-1674 (2015).

Gene Information

• Gene Name: GFAP glial fibrillary acidic protein [ Homo sapiens (human) ]
• Official Symbol: GFAP
• Synonyms: GFAP; glial fibrillary acidic protein; glial fibrillary acidic protein
• Gene ID: 2670
• mRNA Refseq: NM_002055
• Protein Refseq: NP_002046
• MIM: 137780
• UniProt ID: P14136