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Recombinant Human GFAP Protein, His-tagged

Cat.No. : GFAP-01H
Product Overview : Recombinant human full length GFAP protein with a polyhistidine tag at the C-terminus was expressed in human 293 cells.
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  • Gene Information
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Description : This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Source : HEK293
Species : Human
Tag : His
Molecular Mass : 52.9 kDa
Endotoxin : Endotoxin level is < 0.1 ng/μg of protein (<1EU /μg)
Purity : >90% by SDS-PAGE gel and Coomassie Blue staining
Applications : Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Storage Buffer : Purified protein formulated in a sterile solution of PBS buffer, pH 7.2, without any preservatives
Gene Name : GFAP glial fibrillary acidic protein [ Homo sapiens (human) ]
Official Symbol : GFAP
Synonyms : GFAP; glial fibrillary acidic protein; ALXDRD; glial fibrillary acidic protein
Gene ID : 2670
mRNA Refseq : NM_002055
Protein Refseq : NP_002046
MIM : 137780
UniProt ID : P14136

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the main function of GFAP in the central nervous system? 04/04/2022

GFAP is crucial for maintaining the structure and function of astrocytes in the CNS.

How is GFAP used as a biomarker in neurological studies? 03/12/2022

GFAP is used as a biomarker to assess astrocyte activation and neural damage.

How does GFAP contribute to the structure and support of astrocytes? 01/27/2022

It forms intermediate filaments, providing mechanical support and stability to astrocytes.

What role does GFAP play in the response to brain injury? 12/14/2020

It plays a protective role, participating in the glial scar formation post-injury.

How can dysregulation of GFAP affect neural function? 11/28/2020

Dysregulation of GFAP can lead to impaired astrocyte function and neural dysfunction.

In which conditions is an increase in GFAP levels observed? 05/16/2020

Increased GFAP levels are observed in gliosis, neurodegenerative diseases, and brain injuries.

Are there therapeutic interventions targeting GFAP for neurological disorders? 01/28/2020

Therapeutic interventions may aim at modulating GFAP expression to mitigate neural damage.

Customer Reviews (3)

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Reviews
05/11/2022

    Fast, efficient customer service.

    12/12/2021

      Product works great in assays.

      07/16/2021

        No problems, satisfied customer.

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