gsk3b
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  • Official Full Name
  • glycogen synthase kinase 3 beta
  • Background
  • The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
  • Synonyms
  • GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B;
Cat.#:GSK3B-2129HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GSK3B Protein (1-420 aa), His-tagged
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Cat.#:GSK3B-2350HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GSK3B Protein, MYC/DDK-tagged
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Cat.#:GSK3B-4399HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSK3B Protein, GST-tagged
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Cat.#:GSK3B-1886HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-120HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B Protein, DDK-tagged
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Cat.#:GSK3B-28628THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-28630THTag:
Source (Host):Species:Human
Product nameRecombinant Human GSK3B
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Cat.#:GSK3B-326HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human GSK3B protein, GST-tagged
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Cat.#:GSK3B-376HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human GSK3B Protein, His-tagged
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Cat.#:GSK3B-406HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human glycogen synthase kinase 3 beta, His-tagged
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Cat.#:GSK3B-616HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B, His tagged
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Cat.#:GSK3B-735HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GSK3B
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Cat.#:Gsk3b-2521MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Gsk3b, His tagged
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Cat.#:GSK3B-2728RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GSK3B Protein
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Cat.#:GSK3B-8957ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GSK3B
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Cat.#:GSK3B-2649HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1022HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, His-tagged
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Cat.#:GSK3B-1023HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged
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Cat.#:GSK3B-1540HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3 beta, Unactive, GST-tagged
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Cat.#:GSK3B-2857HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (C-79aa), His-tagged
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Cat.#:GSK3B-2858HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSK3B (1-351aa), His-tagged
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Cat.#:GSK3B-717HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human GSK3B cell lysate
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Cat.#:GSK3B-534MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse GSK3B cell lysate
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Involved Pathway

GSK3B involved in several pathways and played different roles in them. We selected most pathways GSK3B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSK3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
ABL2; SHC2; PLCG2; MAP2K2A; MAPK8B; CAMK2G1; AREG; MAP2K4B; PRKCB; SHC4
Chemokine signaling pathway
MAPK3; RLN1; GNAI2; CX3CR1; PLCB1; GNG13; CXCR3; NRAS; CCR6; CCR1
Cell cycle
TOP2A; MAPRE1; BANF1; VRK1; CDKN1BA; MCM3; GADD45BA; RAD1; MCM6; CDC23
PIK-Akt signaling pathway
TSC1; PRL; LAMB2; IFNA10; IFNA1; IL6; TLR2; CREB3L3; ITGA10; PPP2CB
Wnt signaling pathway
FBXW11A; VANGL2; FZD3B; DAAM1B; FZD2; DKK4; CSNK2A2A; RAC3A; GSK3AA; PPP3CCA
Hedgehog signaling pathway
CSNK1G1; WNT8A; CSNK1DA; GLI2A; IHHA; WNT6; GLI2; SMO; WNT16; CSNK1G3
Axon guidance
ROBO2; EFNB2; FGF18B; CLTA; ARPC1B; SEMA3AA; PLXNC1; MARK3; RGMB; EFNA3B
Hippo signaling pathway
BMPR1B; ITGB2L; PPP2R2A; WNT6; CTGF; RASSF1; PPP2CB; ID1; PPP1CC; NF2
Focal adhesion
THBS3; PTENA; PRKCG; CAPN2L; FN1; COL6A1; COL6A3; COL6A2; RAP1A; COL24A1
Signaling pathways regulating pluripotency of stem cells
IGF1R; BMP4; LEFTY2; HOXB1; SOX2; DLX5; KLF4; INHBA; SMAD5; AXIN1
T cell receptor signaling pathway
CARD11; ZAP70; MAP2K1; TNF; SHB; PIK3CD; VAV1; LAT; NFATC2; RELA
B cell receptor signaling pathway
CMTM3; PDPK1A; cgr2b; PPP3R1; VAV3; BANK1; CD72; PILRB; PPP3CB; DUSP4
Neurotrophin signaling pathway
MAP2K2; CALML5; ARHGDIG; RAP1B; IRAK2; PIK3CD; FASLG; MAPK11; NTRK2; YWHAE
Dopaminergic synapse
KIF5C; PPP2CA; MAOA; PPP2R1B; GNG7; GNGT1; GNAI3; ATF4; PRKCG; GNAO1
Insulin signaling pathway
TSC1; INSRA; FASN; PPP1CAB; SH2B2; PHKG1A; AKT2L; PPP1CB; IKBKB; RPS6KB1B
Melanogenesis
GNAO1B; CALML3; PLCB1; DCT; NRAS; FZD3; WNT7A; WNT2B; KIT; MITFB
Prolactin signaling pathway
LHB; SHC3; MAPK10; ESR2; FOS; SOS1; TNFSF11; FOXO3; SHC4; SOCS4
Thyroid hormone signaling pathway
ATP1B3; HDAC2; SRC; WNT4; MED13; MAP2K1; CCND1; PLCG2; THRB; PLCB1
Insulin resistance
PRKCD; SOCS3B; OGT; CREB3L3L; NFKB1; PRKAB1B; NFKBIAA; SREBF1; INSRB; OGT.1
Non-alcoholic fatty liver disease (NAFLD)
NDUFS5; NDUFA9; NDUFAB1; COX5A; NDUFA8; NDUFB8; CDC42; LEPR; IKBKB; DDIT3
Alzheimers disease
ATP5H; NDUFB3; NDUFC1; CAPN2; NDUFS5; NDUFA2; IDE; SDHC; PSEN1; PLCB2
Hepatitis C
RIPK1; CLDN4; PPP2R2A; EIF2AK1; OSTN; TRAF3; AKT1; IKBKB; MAVS; CLDN7
Measles
HSPA1B; IFNA12; RAB9B; IFNA17; OAS1A; CD209B; IFNA13; RCHY1; CCND1; PIK3CG
Influenza A
HNRNPUL1; FDPS; MAP2K1; PLG; IFNA6; RAE1; TBK1; XPO1; PIK3CG; OAS1B
HTLV-I infection
SLC25A4; IL2RA; CRTC3; PIK3CB; EGR1; HLA-G; PIK3R5; PRKACG; PPP3CB; IL1R2
Epstein-Barr virus infection
ENTPD3; YWHAH; PSMD1; ICAM1; FGR; EP300; PRKACB; GTF2E2; HLA-C; HSPA2
Pathways in cancer
SMAD2; Adcy4; MAPK1; FZD3; PGF; GNGT1; HSP90AB1; VEGFA; KRAS; PIK3R5
Colorectal cancer
CCND1; TCF7L2; CASP9; MSH3; TGFB3; AXIN1; AXIN2; BAX; MLH1; TP53
Endometrial cancer
TCF7L2; PIK3CB; BAD; MAPK3; PIK3R5; ERBB2; CDH1; BRAF; FOXO3; GSK3B
Prostate cancer
PIK3R1; IGF1; BAD; SMARCA4; Pdgfa&Pdgfb; CREB3L3; TCF7; MDM2; RAF1; FGFR2
Basal cell carcinoma
SUFU; FZD3; TCF7; WNT9A; GLI1; BMP4; LEF1; WNT10B; FZD10; PTCH2

Protein Function

GSK3B has several biochemical functions, for example, ATP binding, NF-kappaB binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSK3B itself. We selected most functions GSK3B had, and list some proteins which have the same functions with GSK3B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MAPK1; PEO1; HSPA2; MAP3K8; EGFRA; MAP2K4A; HELZ; P2RX1; ATP2A2; NME1
Function NF-kappaB binding
Related Protein NPM1; AP1S2; FAF1; ANXA4; RPS3; BRMS1; MTDH; NFKBID; FOXP3; TAF4B
Function RNA polymerase II transcription factor binding
Related Protein SPOP; TAL1; MIXL1; TP53; SMAD4; GATA2A; GATA6; SFPI1; ZFPM2A; TRPS1
Function beta-catenin binding
Related Protein SOX9; MED12; DACT3; PTBP3; SMAD3; CTNNA3; TCF7; SOX17; CXADR; TCF7L1A
Function kinase activity
Related Protein ERBB4A; PLK2B; INSRA; TPK1; GM4922; MAPK12B; CDKN1BB; NLK1; PPM1E; MARCKSA
Function p53 binding
Related Protein RNF34; SMYD2; CHD8; GSK3B; RCHY1; SETD7; RFWD3; NUAK1; BRD7; EP300
Function protein binding
Related Protein SYNGR1; C3orf62; DSG1A; RPL10; EDC3; STX6; OAZ1; SIAH2; SCYL3; AP1G1
Function protein kinase A catalytic subunit binding
Related Protein PKIA; PRKAR1B; CSK; PRKAR2A; KCNQ1; EZR; GSK3B; PRKAR2B; RYR2; PJA2
Function protein kinase binding
Related Protein CD3E; CDK5; CCNE2; PIH1D1; TNNI3; ATG13; NIPAL1; DLG1L; IKBKB; CAV2
Function protein serine/threonine kinase activity
Related Protein CDK5; MAPK11; MAP3K13; TTK; CAMK2D1; MAPK8B; PBK; ROCK2A; ROCK2; CDKL5
Function tau-protein kinase activity
Related Protein MARK4; CDK5; GSK3B; MARK1; PHKG1; PRKAA1; GSK3A; PHKG2; MARK2; CSNK1D
Function ubiquitin protein ligase binding
Related Protein MDM2; WFS1; ARRB2; PRDX6; UBXN6; XRCC5; RIPK1; HERC2; PARK2; ZFP746

Interacting Protein

GSK3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSK3B here. Most of them are supplied by our site. Hope this information will be useful for your research of GSK3B.
AXIN1

GSK3B Related Articles

Solich, J; Kolasa, M; et al. Effect of desipramine on gene expression in the mouse frontal cortex - Microarray study. PHARMACOLOGICAL REPORTS 67:345-348(2015).
Yuan, YH; Yan, WF; et al. The molecular mechanism of rotenone-induced alpha-synuclein aggregation: Emphasizing the role of the calcium/GSK3 beta pathway. TOXICOLOGY LETTERS 233:163-171(2015).