GSK3B
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Official Full Name
glycogen synthase kinase 3 beta
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Overview
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] -
Synonyms
GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B;
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- Involved Pathway
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- GSK3B Related Signal Pathway
GSK3B involved in several pathways and played different roles in them. We selected most pathways GSK3B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSK3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | GSK3AA;PIK3CB;PRKCBA;GRB2A;SHC3;NRAS;GAB1;PAK7;NCK2A |
| Chemokine signaling pathway | GNG4;CCL21;GM2506;DOCK2;CCL27;CXCR2;CXCL6;NRAS;RAC1 |
| Cell cycle | TFDP2;PHF8;TBC1D8;SMAD3B;NCAPD3;RAD9;CENPL;PIANP;CENPA |
| PIK-Akt signaling pathway | ITGA7;MLST8;VEGFA;F2R;DDIT4;VEGFB;CCND2;IKBKG;FGF18 |
| Wnt signaling pathway | PRKACA;FZD7B;BTRC;PPP3R2;GSK3AA;SIAH2L;CAMK2B;SENP2;SFRP5 |
| Hedgehog signaling pathway | PRKACG;GLI3;WNT2BB;GLI1;WNT1;PTCH1;CSNK1G1;GLI2;SUFU |
| Axon guidance | SEMA7A;RGMA;EFNB3;KDR;EFNA3B;NETO2;NTN1A;RGS3;KCNQ2 |
| Hippo signaling pathway | SMAD1;ID2;PPP2R2D;WNT9A;WNT5A;SMAD3;TEAD1;DLG1;WNT3A |
| Focal adhesion | COL5A2;VCL;PAK2B;COL4A1;CCND3;VEGFA;VEGFAA;ACTN1;MAPK6 |
| Signaling pathways regulating pluripotency of stem cells | AKT2;KLF4;INHBA;PIK3CD;WNT2B;DLX5;LIF;WNT9A;STAT3 |
| T cell receptor signaling pathway | LCK;TNF;MAPK13;ZAP70;PPP3R1;NRAS;EVLB;NFKB1;DBNLB |
| B cell receptor signaling pathway | MAPK3;PTPN18;DUSP4;PLEKHA1;NEDD9;INPPL1;NFKBIA;BCL10;PIK3R5 |
| Neurotrophin signaling pathway | MAPK1;KIDINS220;CALML3;Fasl;SHC1;HRAS;MAPK10;ATF4;GAB1 |
| Dopaminergic synapse | MAPK11;SCN1A;PPP2R5D;PRKCB;COMT;CALML5;CREB3L3;GNG10;GSK3B |
| Insulin signaling pathway | PRKAB2;CBLB;PIK3CB;GRB2B;PIK3R2;PPP1CBL;PYGL;KRAS;MKNK2A |
| Melanogenesis | FZD1;CAMK2B;DVL3A;CALM1;MAP2K2A;KITLGA;Adcy4;PLCB1;PRKCG |
| Prolactin signaling pathway | MAPK13;PIK3CD;SOCS6;FOS;TNFRSF11A;MAPK1;NEK3;INS2;PIK3R2 |
| Thyroid hormone signaling pathway | MED27;TSC2;PRKCG;ACTG1;PLCB1;ATP1B4;HDAC3;KRAS;DIO2 |
| Insulin resistance | NFKBIAB;PRKCZ;PDPK1;SLC2A1;RPS6KB1;PRKCBB;GSK3B;OGT;PPP1CBL |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFS5;NDUFB8;KCNA3;NDUFB7;TNFRSF1A;NDUFA10;COX7A2L;PRKAB2;INS1 |
| Alzheimers disease | UQCRH;ATP5G3;Atp5g2;NCSTN;CALM2;ITPR3;NDUFA12;NDUFA8;NDUFA3 |
| Hepatitis C | BRAF;STAT3;TYK2;IRF3;IFNA8;LDLR;CLDN8;OAS2;PIK3CB |
| Measles | IFNA21;FCGR2B;EIF2AK1;TNFSF10;IL12B;PIK3R3;CD209;HSPA1B;TAB2 |
| Influenza A | HLA-DQA1;SOCS3;BMA1;RELA;TLR4;LOC100686744;HSPA1A;MX1;TMPRSS4 |
| HTLV-I infection | XPO1;HLA-DQB1;ATM;TGFB3;PDGFB;PDGFRA;NFATC1;RELB;NFKB1 |
| Epstein-Barr virus infection | GSK3B;CSNK2A2;ENTPD1;HSPB2;GTF2B;SPN;CCNA1;RBPJL;HLA-F |
| Pathways in cancer | FADD;GNG2;FGF18;RALB;PIK3R5;KIT;WNT2;FZD2;WNT3A |
| Colorectal cancer | BAX;CCND1;RHOA;PIK3CG;AKT1;GSK3B;Casp3;MLH1;TGFBR2 |
| Endometrial cancer | MAPK3;PIK3R2;MAPK1;APC2;PIK3CA;KRAS;PIK3R1;PIK3CB;AXIN2 |
| Prostate cancer | FOXO1;AKT1;TRP53;PIK3R3;RAF1;CREB3L2;FOXA1;IGF1R;AKT2 |
| Basal cell carcinoma | GLI2;WNT16;WNT2;WNT5A;WNT3;APC2;WNT7B;SUFU;WNT11 |
GSK3B has several biochemical functions, for example, ATP binding, NF-kappaB binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSK3B itself. We selected most functions GSK3B had, and list some proteins which have the same functions with GSK3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DDX3;UBE2G1B;MYO6;STK38A;CAMKV;MARS;RPS6KA6;DDX31;COASY |
| NF-kappaB binding | DNAJA3;AP1S2;RPS3;COMMD7;HDAC2;MTDH;ANKRD42;ANXA4;NFKBIA |
| RNA polymerase II transcription factor binding | GATA2A;ATF4;ZFPM2A;SPI1;NFATC1;T;GATA2;PITX2;KDM1A |
| beta-catenin binding | CALCOCO1;PTBP3;ASH2L;TRPC4;TAX1BP3;CARM1;CDH5;GLI3;SALL1 |
| kinase activity | cka1;WNK2;MAP2K4B;NLK2;CDK5R1;PRKD3;WEE2;CAMK1GB;NME2B.1 |
| p53 binding | RFWD3;SMARCA4;USP10;RFFL;HSPD1;GSK3B;PTTG1IP;AXIN1;ZNF385B |
| protein binding | MED16;ARHGAP33;HOXB6;RIC8;GTF2F1;SELPLG;MEIS1;SH3PXD2B;KCND3 |
| protein kinase A catalytic subunit binding | PJA2;RYR2;SOX9;GSK3B;PRKAR1B;PKIA;GSK3A;EZR;PRKAR2B |
| protein kinase binding | FGF19;PARN;PAX6;MAP3K1;SHC4;MAML1;KCNA5;TRIM22;LATS1 |
| protein serine/threonine kinase activity | CAMKK1A;PHKG2;MAST2;SLK;TTBK1;CDC7;CDK12;CDK15;GSK3B |
| tau-protein kinase activity | PRKAA1;GSK3B;MARK1;MARK2;PHKG2;CSNK1D;CDK5;GSK3A;PHKG1 |
| ubiquitin protein ligase binding | UBXN1;RPA3;CUL2;PML;RFFL;PRKAR2A;CDC34B;TRIOBP;UBE2V2 |
GSK3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSK3B here. Most of them are supplied by our site. Hope this information will be useful for your research of GSK3B.
AXIN1
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Customer Reviews (3)
Write a reviewIn response to the problems in the experiment, the technician gave a satisfactory solution.
High protein concentrations were received and the desired experimental results were obtained.
GSK3B proteins purchased are as advertised and the quality of the product is guaranteed.
Q&As (5)
Ask a questionGSK3B expression increased with increasing severity of acute edematous pancreatitis.
GSK3B may have the effect of promoting the survival and proliferation of cervical and ovarian cancer tumor cells and inhibiting tumor cell apoptosis.
GSK3B is closely related to the study of cervical cancer, gastric cancer, breast cancer and other diseases.
GSK3B is involved in the regulation of cell proliferation, differentiation, survival and apoptosis.
In pancreatic tissues, GSK3B is localized to the cytoplasm.
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