Recombinant Human GSK3B Protein, His-tagged
Cat.No. : | GSK3B-2219H |
Product Overview : | Recombinant Human GSK3B Protein (Lys122-Thr375) with a N-His tag was expressed in E. coli. |
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Description : | The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 32.6 kDa Accurate Molecular Mass: 33 kDa |
Protein length : | Lys122-Thr375 |
Endotoxin : | <1.0 EU per 1µg (determined by the LAL method). |
Purity : | > 97% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | GSK3B glycogen synthase kinase 3 beta [ Homo sapiens (human) ] |
Official Symbol : | GSK3B |
Synonyms : | GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; |
Gene ID : | 2932 |
mRNA Refseq : | NM_001146156 |
Protein Refseq : | NP_001139628 |
MIM : | 605004 |
UniProt ID : | P49841 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIn response to the problems in the experiment, the technician gave a satisfactory solution.
High protein concentrations were received and the desired experimental results were obtained.
GSK3B proteins purchased are as advertised and the quality of the product is guaranteed.
Q&As (5)
Ask a questionGSK3B expression increased with increasing severity of acute edematous pancreatitis.
GSK3B may have the effect of promoting the survival and proliferation of cervical and ovarian cancer tumor cells and inhibiting tumor cell apoptosis.
GSK3B is closely related to the study of cervical cancer, gastric cancer, breast cancer and other diseases.
GSK3B is involved in the regulation of cell proliferation, differentiation, survival and apoptosis.
In pancreatic tissues, GSK3B is localized to the cytoplasm.
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