Recombinant Human GSK3B Protein, His-tagged

Cat.No. : GSK3B-2219H
Product Overview : Recombinant Human GSK3B Protein (Lys122-Thr375) with a N-His tag was expressed in E. coli.
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Description : The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 32.6 kDa
Accurate Molecular Mass: 33 kDa
Protein length : Lys122-Thr375
Endotoxin : <1.0 EU per 1µg (determined by the LAL method).
Purity : > 97%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : GSK3B glycogen synthase kinase 3 beta [ Homo sapiens (human) ]
Official Symbol : GSK3B
Synonyms : GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B;
Gene ID : 2932
mRNA Refseq : NM_001146156
Protein Refseq : NP_001139628
MIM : 605004
UniProt ID : P49841

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
10/19/2022

    In response to the problems in the experiment, the technician gave a satisfactory solution.

    05/02/2022

      High protein concentrations were received and the desired experimental results were obtained.

      04/07/2022

        GSK3B proteins purchased are as advertised and the quality of the product is guaranteed.

        Q&As (5)

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        What is the relationship between GSK3B expression and the severity of acute edematous pancreatitis development? 01/25/2022

        GSK3B expression increased with increasing severity of acute edematous pancreatitis.

        What is the relationship between GSK3B and the development of cervical and ovarian cancer? 01/08/2022

        GSK3B may have the effect of promoting the survival and proliferation of cervical and ovarian cancer tumor cells and inhibiting tumor cell apoptosis.

        GSK3B is closely related to the study of which diseases? 11/26/2021

        GSK3B is closely related to the study of cervical cancer, gastric cancer, breast cancer and other diseases.

        What biological processes is GSK3B involved in? 01/02/2021

        GSK3B is involved in the regulation of cell proliferation, differentiation, survival and apoptosis.

        Where is GSK3B located in pancreatic tissue? 08/13/2020

        In pancreatic tissues, GSK3B is localized to the cytoplasm.

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