Recombinant Human GSK3B Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: GSK3B-012H
• Product Overview: GSK3B MS Standard C13 and N15-labeled recombinant protein (NP_002084) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 47.9 kDa
• AA Sequence: MSGRPRTTSFAESCKPVQQPSAFGS MKVSRDKDGSKVTTVVATPGQGPDR PQEVSYTDTKVIGNGSFGVVYQAKL CDSGELVAIKKVLQDKRFKNRELQI MRKLDHCNIVRLRYFFYSSGEKKDE VYLNLVLDYVPETVYRVARHYSRAK QTLPVIYVKLYMYQLFRSLAYIHSF GICHRDIKPQNLLLDPDTAVLKLCD FGSAKQLVRGEPNVSYICSRYYRAP ELIFGATDYTSSIDVWSAGCVLAEL LLGQPIFPGDSGVDQLVEIIKVLGT PTREQIREMNPNYTEFKFPQIKAHP WTKDSSGTGHFTSGVRVFRPRTPPE AIALCSRLLEYTPTARLTPLEACAH SFFDELRDPNVKLPNGRDTPALFNF TTQELSSNPPLATILIPPHARIQAA ASTPTNATAASDANTGDRGQTNNAA SASASNSTTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: GSK3B glycogen synthase kinase 3 beta [ Homo sapiens (human) ]
• Official Symbol: GSK3B
• Synonyms: GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; GSK3beta isoform; glycogen synthase kinase-3 beta; GSK-3 beta; serine/threonine-protein kinase GSK3B; EC 2.7.11.1; EC 2.7.11.26
• Gene ID: 2932
• mRNA Refseq: NM_002093
• Protein Refseq: NP_002084
• MIM: 605004
• UniProt ID: P49841

Reviews

10/19/2022

In response to the problems in the experiment, the technician gave a satisfactory solution.

05/02/2022

High protein concentrations were received and the desired experimental results were obtained.

04/07/2022

GSK3B proteins purchased are as advertised and the quality of the product is guaranteed.

Q&As

What is the relationship between GSK3B expression and the severity of acute edematous pancreatitis development?

GSK3B expression increased with increasing severity of acute edematous pancreatitis.

What is the relationship between GSK3B and the development of cervical and ovarian cancer?

GSK3B may have the effect of promoting the survival and proliferation of cervical and ovarian cancer tumor cells and inhibiting tumor cell apoptosis.

GSK3B is closely related to the study of which diseases?

GSK3B is closely related to the study of cervical cancer, gastric cancer, breast cancer and other diseases.

What biological processes is GSK3B involved in?

GSK3B is involved in the regulation of cell proliferation, differentiation, survival and apoptosis.

Where is GSK3B located in pancreatic tissue?

In pancreatic tissues, GSK3B is localized to the cytoplasm.