Il12rb2

  • Official Full Name

    interleukin 12 receptor, beta 2

  • Overview

    The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohns disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

  • Synonyms

    IL12RB2;interleukin 12 receptor, beta 2;interleukin-12 receptor subunit beta-2;I12R2_HUMAN;IL-12 receptor subunit beta-2;IL-12R subunit beta-2;IL-12R-beta-2;IL-12RB2;IL12 receptor beta 2;IL12R beta2;Interleukin 12 receptor beta 2;Interleukin 12 receptor beta 2 chain;RP11 102M16.1;IL-12 receptor beta 2;interleukin-12 receptor beta-2 chain;RP11-102M16.1

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Zebrafish
  • Cynomolgus
  • HEK293
  • Mammalian Cells
  • E.coli
  • Wheat Germ
  • Yeast
  • Human Cells
  • Insect Cells
  • His
  • Fc
  • GST
  • Non
  • Avi
  • mFc
Cat.# Product name Source (Host) Species Tag Protein Length Price
Il12rb2-4006M Active Recombinant Mouse Il12rb2 protein, His-tagged HEK293 Mouse His Met1-Asn637
IL12RB2-73H Recombinant Human IL12RB2 protein, Fc-tagged HEK293 Human Fc
IL12RB2-9483H Active Recombinant Human IL12RB2 Protein, Fc/His-tagged Mammalian Cells Human Fc&His 24-622 a.a.
IL12RB2-1464H Recombinant Human IL12RB2 protein, His-tagged E.coli Human His Trp145~Ala275
IL12RB2-1465H Recombinant Human IL12RB2 protein, His & GST-tagged E.coli Human GST&His Tyr559~Gln647
Il12rb2-1466M Recombinant Mouse Il12rb2 protein, His-tagged E.coli Mouse His Met285~Gln441
Il12rb2-1467M Recombinant Mouse Il12rb2 protein, His-tagged E.coli Mouse His Thr455~Arg606
IL12RB2-29640TH Recombinant Human IL12RB2 Wheat Germ Human Non 110 amino acids
IL12RB2-3884H Recombinant Human IL12RB2 protein, His-tagged Yeast Human His 24-622aa
IL12RB2-5006C Recombinant Chicken IL12RB2 Mammalian Cells Chicken His
IL12RB2-6304Z Recombinant Zebrafish IL12RB2 Mammalian Cells Zebrafish His
IL12RB2-2142MCL Recombinant Mouse IL12RB2 cell lysate Human Cells Mouse Non
IL12RB2-214H Recombinant Human IL12RB2 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IL12RB2-214H-B Recombinant Human IL12RB2 Protein Pre-coupled Magnetic Beads HEK293 Human
IL12RB2-3230H Recombinant Human IL12RB2 Protein, His-tagged HEK293 Human His
IL12RB2-3233H Active Recombinant Human IL12RB2 protein, His-tagged HEK293 Human His Lys 24 - Asn 622
IL12RB2-34C Recombinant Cynomolgus IL12RB2 protein, mFc-tagged HEK293 Cynomolgus mFc Lys24-Asn623
IL12RB2-3885H Recombinant Human IL12RB2 protein, His-tagged Insect Cells Human His Met1-Asn622
Il12rb2-5695M Recombinant Mouse Il12rb2 Protein (Met1-Asn637), C-Fc tagged Mammalian Cells Mouse Fc Met1-Asn637

    Involved Pathway

    Il12rb2 involved in several pathways and played different roles in them. We selected most pathways Il12rb2 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with Il12rb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Jak-STAT signaling pathway GH1,CCND1,IL12A,IFNGR1,PIK3R3A,IRX1,IFNA6,STAT3,LEPA,AKT2L
    Cytokine-cytokine receptor interaction BMPR1A,IL28RA,PRL,VEGFB,KITLGA,OSTN,VEGFA,THPO,IFNAR2,IL8L1
    Inflammatory bowel disease (IBD) HLA-DQA1,IL12A,IL12B,IL13,STAT4,RORC,MAF,NFKB1,STAT3,IL21

    Protein Function

    Il12rb2 has several biochemical functions, for example, cytokine receptor activity,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il12rb2 itself. We selected most functions Il12rb2 had, and list some proteins which have the same functions with Il12rb2. You can find most of the proteins on our site.

    Function Related Protein
    cytokine receptor activity F3A,CRFB16,F3B,CRFB2,CRFB15,IL12RB1,F3,IL1RL1,CD74,LIFRA
    protein kinase binding LIPE,SNAP91,CDK5R1,CDK5RAP1,MAML1,JTB,CAMK2N1,NCS1,STAT3,PDPK1

    Interacting Protein

    Il12rb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il12rb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il12rb2.

    STAT4;SOCS3

    Il12rb2 Related Signal Pathway

    Resources

    Gene Families

    What is the interleukin (IL) factors and IL gene family

    Research Area

    Negative Regulators of the Jak/STAT Pathway
    Receptors in the Jak/STAT Pathway
    T Cell Cytokine Signaling
    Th1 Cells
    IL-12 Family Receptors

    References

    • Holle, JU; Gross, WL; et al. Genetic risk factors for vasculitis. INTERNIST 55:128-+(2014).
    • Cho, S; Kim, J; et al. Immunopathogenic characterization of cutaneous inflammation in Behcet's disease. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 28:51-57(2014).

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