• Official Full Name

    interleukin 12 receptor, beta 2

  • Overview

    The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohns disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
  • Synonyms

    IL12RB2; interleukin 12 receptor, beta 2; interleukin-12 receptor subunit beta-2; I12R2_HUMAN; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; IL-12RB2; IL12 receptor beta 2; IL12R beta2; Interleukin 12 receptor beta 2; Interleukin 12 receptor beta 2 chain; RP11 102M16.1; IL-12 receptor beta 2; interleukin-12 receptor beta-2 chain; RP11-102M16.1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Cynomolgus
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • His
  • His (Fc)
  • Avi
  • His|GST
  • mFc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL12RB2-9483H Active Recombinant Human IL12RB2 Protein, Fc/His-tagged Mammalian cells Fc/His
Human IL12RB2-29640TH Recombinant Human IL12RB2 Wheat Germ N/A 110 amino acids
Human IL12RB2-3884H Recombinant Human IL12RB2 protein, His-tagged Yeast His 24-622aa
Human IL12RB2-1464H Recombinant Human IL12RB2 protein, His-tagged E.coli His Trp145~Ala275 ((Accession # Q99665)
Human IL12RB2-1465H Recombinant Human IL12RB2 protein, His & GST-tagged E.coli His/GST Tyr559~Gln647 (Accession # Q99665)
Human IL12RB2-3230H Recombinant Human IL12RB2 Protein, His-tagged HEK293 His
Human IL12RB2-3885H Recombinant Human IL12RB2 protein, His-tagged Insect Cell His Met1-Asn622
Human IL12RB2-214H Recombinant Human IL12RB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL12RB2-3233H Active Recombinant Human IL12RB2 protein, His-tagged HEK293 His Lys 24 - Asn 622
Human IL12RB2-73H Recombinant Human IL12RB2 protein, Fc-tagged HEK293 Fc
Human IL12RB2-214H-B Recombinant Human IL12RB2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Il12rb2-1467M Recombinant Mouse Il12rb2 protein, His-tagged E.coli His Thr455~Arg606 (Accession # P97378)
Mouse Il12rb2-1466M Recombinant Mouse Il12rb2 protein, His-tagged E.coli His Met285~Gln441 (Accession # P97378)
Mouse Il12rb2-4006M Active Recombinant Mouse Il12rb2 protein, His-tagged HEK293 His Met1-Asn637
Mouse IL12RB2-2142MCL Recombinant Mouse IL12RB2 cell lysate Human Cell N/A
Mouse Il12rb2-5695M Recombinant Mouse Il12rb2 Protein (Met1-Asn637), C-Fc tagged Mammalian cells C-Fc Met1-Asn637
Cynomolgus IL12RB2-34C Recombinant Cynomolgus IL12RB2 protein, mFc-tagged HEK293 mFc Lys24-Asn623
Zebrafish IL12RB2-6304Z Recombinant Zebrafish IL12RB2 Mammalian Cell His
Chicken IL12RB2-5006C Recombinant Chicken IL12RB2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Il12rb2 Related Signal Pathway

Il12rb2 involved in several pathways and played different roles in them. We selected most pathways Il12rb2 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with Il12rb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL20RB;IL17RB;Il23a;IFNG;IFNG1-2;CXCL10;CTF1;Il23a; Il12b;CRFB16
Jak-STAT signaling pathwayLEPA;IL22RA2;IL20RA;IFNA13;STAT1A;IL5RA;EP300;PIK3R3;EPO
Inflammatory bowel disease (IBD)IL23R;RORA;IL4R;IFNGR2;RORC;TLR4;HLA-DQA1;Il23a;STAT3

Il12rb2 has several biochemical functions, for example, cytokine receptor activity, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il12rb2 itself. We selected most functions Il12rb2 had, and list some proteins which have the same functions with Il12rb2. You can find most of the proteins on our site.

Function Related Protein
cytokine receptor activityIL12B;IL1RL1;IL11RA;CRFB15;IL28RA;IL4R.1;IL13RA1;LEPR;CRFB2
protein kinase bindingDNAJC3;PRKCZ;MAPK8IP2;C10orf46;KCNA5;KIF13B;FAM83D;PTPN6;EEF1A1

Il12rb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il12rb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il12rb2.


Gene Family


Research Area

Related articles

Holle, JU; Gross, WL; et al. Genetic risk factors for vasculitis. INTERNIST 55:128-+(2014).
Cho, S; Kim, J; et al. Immunopathogenic characterization of cutaneous inflammation in Behcet's disease. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 28:51-57(2014).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
Could you explain the benefits of using CRISPR/Cas9-mediated gene tagging to track IL12RB2 localization? 12/04/2022

CRISPR/Cas9 gene tagging tracks IL12RB2 localization dynamically.

What methods are suitable for assessing IL12RB2 dimerization and its effect on downstream signaling? 10/23/2022

Crosslinking and immunoprecipitation study IL12RB2 dimerization.

How can ChIP-seq analysis provide insights into the genes regulated by IL12RB2? 06/30/2022

ChIP-seq identifies genes under IL12RB2's regulation.

How does quantitative RT-PCR validate IL12RB2's impact on cytokine-induced gene expression? 05/24/2022

Quantitative RT-PCR validates IL12RB2's impact on gene expression.

What experimental approaches can validate IL12RB2's involvement in signal transduction pathways? 04/01/2022

Functional assays validate IL12RB2's role in signaling pathways.

What are the advantages of utilizing flow cytometry to analyze cell-specific IL12RB2 expression? 03/26/2022

Flow cytometry quantifies IL12RB2 expression on specific cell types.

Can you elaborate on the use of confocal microscopy to visualize the subcellular distribution of IL12RB2? 11/22/2021

Confocal microscopy visualizes IL12RB2 distribution in cells.

How can siRNA knockdown experiments reveal the functional role of IL12RB2? 02/04/2021

siRNA knockdown reveals IL12RB2's functional significance.

How does co-immunoprecipitation assist in understanding the protein-protein interactions of IL12RB2? 01/15/2021

Co-immunoprecipitation unveils IL12RB2's protein interactions.

What techniques are effective in studying IL12RB2's interaction with cytokines IL12A and IL23A? 04/06/2019

Co-immunoprecipitation and ELISA assay cytokine interactions with IL12RB2.

Customer Reviews (3)

Write a review

    Good for receptor binding studies.


      Consistent in bioactivity.


        Suitable for flow cytometry.

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