Il12rb2 Protein


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Official Full Name interleukin 12 receptor, beta 2
Background The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohns disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Synonyms IL12RB2; interleukin 12 receptor, beta 2; interleukin-12 receptor subunit beta-2; I12R2_HUMAN; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; IL-12RB2; IL12 receptor beta 2; IL12R beta2; Interleukin 12 receptor beta 2; Interleukin 12 receptor beta 2 chain; RP11 102M16.1; IL-12 receptor beta 2; interleukin-12 receptor beta-2 chain; RP11-102M16.1
    • Species :
    • Chicken
    • Cynomolgus
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • Fc/His
    • His
    • GST
    • mFc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL12RB2-3884H Recombinant Human IL12RB2 protein, His-tagged Yeast His Inquiry
    Human IL12RB2-1464H Recombinant Human IL12RB2 protein, His-tagged E.coli His Inquiry
    Human IL12RB2-1465H Recombinant Human IL12RB2 protein, His & GST-tagged E.coli His/GST Inquiry
    Human IL12RB2-29640TH Recombinant Human IL12RB2 Wheat Germ N/A Inquiry
    Mouse Il12rb2-1466M Recombinant Mouse Il12rb2 protein, His-tagged E.coli His Inquiry
    Mouse Il12rb2-1467M Recombinant Mouse Il12rb2 protein, His-tagged E.coli His Inquiry
    Mouse Il12rb2-4006M Recombinant Mouse Il12rb2, His tagged Human Cell His Inquiry
    Chicken IL12RB2-5006C Recombinant Chicken IL12RB2 Mammalian Cell His Inquiry
    Zebrafish IL12RB2-6304Z Recombinant Zebrafish IL12RB2 Mammalian Cell His Inquiry
    Mouse IL12RB2-2142MCL Recombinant Mouse IL12RB2 cell lysate Human Cell N/A Inquiry
    Human IL12RB2-3233H Recombinant Human IL12RB2 protein, His-tagged HEK293 His Inquiry
    Cynomolgus IL12RB2-34C Recombinant Cynomolgus IL12RB2 protein, mFc-tagged HEK293 mFc Inquiry
    Human IL12RB2-73H Recombinant Human IL12RB2 protein, Fc-tagged HEK293 Fc Inquiry
    Human IL12RB2-3230H Recombinant Human IL12RB2 Protein, His-tagged HEK293 His Inquiry
    Human IL12RB2-3885H Recombinant Human IL12RB2 protein, His-tagged Insect Cell His Inquiry
    Human IL12RB2-9483H Recombinant Human IL12RB2 Protein, Fc/His-tagged Mammalian cells Fc/His Inquiry

    Il12rb2 involved in several pathways and played different roles in them. We selected most pathways Il12rb2 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with Il12rb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL4R; GDF5; TGFB1; IL12RB1; TGFBR2; TNFRSF6B; CRFB4; IL19; KITLGA; Il4ra
    Jak-STAT signaling pathway AOX1; IL2RGA; Ifna11; PIK3R2; IL11RA; EP300; PIK3R1; STAT3; IL13; BCL2
    Inflammatory bowel disease (IBD) HLA-DOB; IL4; HLA-DRB4; IFNGR1; Il2; IL12B; IL18RAP; NFKB1; IL21; IL13

    Il12rb2 has several biochemical functions, for example, cytokine receptor activity, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il12rb2 itself. We selected most functions Il12rb2 had, and list some proteins which have the same functions with Il12rb2. You can find most of the proteins on our site.

    Function Related Protein
    cytokine receptor activity CRFB4; CD74; CRFB16; CRFB6; IL15RA; IL28RA; Il6ra; IRX1; IL13RA2; IL21R.2
    protein kinase binding CDKN2C; FBXO5; B4GALT1; DAXX; ACVRL1; AKAP7; CCND3; HDAC7; WAS; PRKCZ

    Il12rb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il12rb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il12rb2.

    STAT4; SOCS3

    Holle, JU; Gross, WL; et al. Genetic risk factors for vasculitis. INTERNIST 55:128-+(2014).
    Cho, S; Kim, J; et al. Immunopathogenic characterization of cutaneous inflammation in Behcet's disease. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 28:51-57(2014).

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