IL18RAP

  • Official Full Name

    interleukin 18 receptor accessory protein

  • Overview

    The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
  • Synonyms

    IL18RAP; Accessory protein like; Accessory protein-like; AcPL; CD218 antigen-like family member B; CD218b; CDw218b; I18RA_HUMAN; IL 18RAcP; IL 1R accessory protein like; IL 1R7; IL 1RAcPL; IL-18 receptor accessory protein; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R accessory protein-like; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RAP; IL18Rbeta; Interleukin 18 receptor accessory protein; Interleukin-1 receptor 7; Interleukin-18 receptor accessory protein; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rhesus
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • Fc|His
  • hFc
  • hIgG
  • Avi
  • His (Fc)
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL18RAP-1073H Active Recombinant Human IL18RAP Protein, Fc Chimera Mammalian cells Fc
Human IL18RAP-3150H Active Recombinant Human IL18RAP, His tagged HEK293 His Met 1-Gly 357
Human IL18RAP-194H Recombinant Human IL18RAP Protein, Fc-tagged HEK293 Fc
Human IL18RAP-2255H Recombinant Human Interleukin 18 Receptor Accessory Protein, Fc-His Human Cell Fc
Human IL18RAP-881H Recombinant Human IL18RAP Protein, Fc/His-tagged HEK293 Fc/His
Human IL18RAP-880H Recombinant Human IL18RAP Protein, His-tagged HEK293 His
Human IL18RAP-1658H Recombinant Human Interleukin 18 Receptor Accessory Protein, Fc-tagged Mammalian cells Fc
Human IL18RAP-1755H Recombinant Human IL18RAP protein, His & GST-tagged E.coli His/GST Leu310~Ser451 (Accession # O95256)
Human IL18RAP-2602HCL Recombinant Human IL18RAP cell lysate Human Cell N/A
Human IL18RAP-0681H Recombinant Human IL18RAP Protein (Phe20-Arg356), N-His tagged E.coli N-His Phe20-Arg356
Human IL18RAP-17H Recombinant Human IL18RAP Protein, hIgG/His-tagged Insect Cell hIgG/His 20-356
Human IL18RAP-157H Recombinant Human IL18RAP Protein, His-tagged E.coli His
Human IL18RAP-59C Recombinant Cynomolgus IL18RAP Protein, hFc-tagged HEK293 hFc
Human IL18RAP-1863H Recombinant Human IL18RAP protein, His & Avi-tagged, Biotinylated HEK293 His & Avi Phe 20 - Arg 356
Human IL18RAP-58C Recombinant Cynomolgus IL18RAP Protein, His-tagged HEK293 His
Human IL18RAP-5250H Recombinant Human IL18RAP Protein (Met1-Gly357), C-His tagged Mammalian cells C-His Met1-Gly357
Human IL18RAP-97H Recombinant Human IL18RAP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL18RAP-97H-B Recombinant Human IL18RAP Protein Pre-coupled Magnetic Beads HEK293
Mouse Il18rap-514M Active Recombinant Mouse Il18rap, His-tagged Insect Cell His Met1-Glu356
Mouse IL18RAP-922M Active Recombinant Mouse IL18RAP Protein, His-tagged Insect Cell His
Mouse Il18rap-1756M Recombinant Mouse Il18rap protein, His-tagged E.coli His Asn396~Ser548 (Accession # Q9Z2B1)
Mouse Il18rap-1757M Recombinant Mouse Il18rap protein, His-tagged E.coli His Gln117~Arg240 (Accession # Q9Z2B1)
Mouse IL18RAP-001MCL Recombinant Mouse IL18RAP cell lysate Insect Cell N/A
Cynomolgus Monkey IL18RAP-1353CCL Recombinant Cynomolgus IL18RAP cell lysate Human Cell N/A
Homo sapiens (Human) RFL4528HF Recombinant Full Length Human Interleukin-18 Receptor Accessory Protein(Il18Rap) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-599)
Rhesus IL18RAP-8836C Recombinant Rhesus IL18RAP protein, His-tagged HEK293 His Met1-Arg356
Rhesus IL18RAP-8835C Recombinant Rhesus IL18RAP protein, hFc-tagged HEK293 hFc Met1-Arg356
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL18RAP involved in several pathways and played different roles in them. We selected most pathways IL18RAP participated on our site, such as Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18RAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionGH2;BMP7A;MET;GM10591;TNFSF9;IL28RA;CSF3R;IL20RB;KDRL
Inflammatory bowel disease (IBD)HLA-DMB;HLA-DQA2;HLA-DRB1;RORC;SMAD2;IL6;RORA;IL18R1;IL4

IL18RAP has several biochemical functions, for example, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18RAP itself. We selected most functions IL18RAP had, and list some proteins which have the same functions with IL18RAP. You can find most of the proteins on our site.

Function Related Protein
receptor activityGRIA4A;P2RY2;RET;CADM1;LDLR;DARC;CUL5;GRIA3A;LILRB4

IL18RAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18RAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18RAP.

Gene Family

IL

Research Area

  • Q&As
  • Reviews

Q&As (10)

Ask a question
What experimental methods are commonly employed to study the expression patterns and regulation of IL18RAP across different cell types and conditions? 12/01/2021

RT-qPCR, immunohistochemistry, and single-cell RNA sequencing characterize IL18RAP expression levels and regulation in diverse cellular contexts.

What techniques are utilized to investigate the role of IL18RAP in immune responses, inflammation, and diseases, and how do researchers assess its potential as a therapeutic target? 03/15/2021

Animal models, patient samples, and therapeutic interventions elucidate IL18RAP's involvement in immune-related disorders and its potential as a therapeutic target.

Could you provide insights into the experimental approaches used to explore the functional effects of IL18RAP isoforms and their specific contributions to IL18 signaling? 12/21/2020

Isoform-specific knockdown, mutagenesis, and functional assays delineate IL18RAP isoforms' distinct roles in modulating IL18-mediated responses.

How are co-immunoprecipitation, fluorescence resonance energy transfer (FRET), and biophysical assays applied to characterize the interactions between IL18RAP, IL18, and IL18R1? 12/20/2019

Co-immunoprecipitation assays, FRET studies, and biophysical techniques characterize IL18RAP's interactions with IL18 and IL18R1 partners.

What experimental methods are used to elucidate the effects of post-translational modifications, such as glycosylation, on IL18RAP's structure and function? 05/18/2019

Mass spectrometry, mutagenesis, and functional assays investigate the impact of post-translational modifications on IL18RAP's conformation and function.

How do researchers experimentally determine the binding affinity and kinetics of IL18RAP to IL18 and IL18R1, considering its pivotal role in forming the IL18 receptor complex? 11/17/2018

Surface plasmon resonance, bio-layer interferometry, and surface plasmon-enhanced fluorescence assays quantify IL18RAP's binding kinetics to IL18 and IL18R1.

Can you explain the use of knockdown, knockout, and gene editing techniques to uncover the physiological importance of IL18RAP in mediating IL18 signaling? 08/10/2018

siRNA knockdown, CRISPR/Cas9-mediated knockout, and transgenic models unravel IL18RAP's physiological roles and contributions to IL18 signaling.

How are advanced imaging techniques, such as single-molecule imaging and super-resolution microscopy, utilized to visualize the dynamic assembly of the IL18 receptor complex involving IL18RAP? 11/05/2017

Single-molecule imaging, super-resolution microscopy, and live-cell imaging visualize the dynamic assembly of IL18 receptor complexes involving IL18RAP.

Can you elaborate on the strategies used to investigate the structural features of IL18RAP's interaction interfaces with IL18 and IL18R1, and how these interfaces contribute to receptor activation? 10/29/2017

X-ray crystallography, NMR spectroscopy, and computational modeling reveal IL18RAP's structural interactions with IL18 and IL18R1 domains.

How do researchers dissect the intracellular signaling pathways triggered by IL18RAP upon binding to IL18 and its collaboration with IL18R1? 10/09/2017

Phosphoprotein analysis, pathway-specific inhibitors, and functional assays dissect IL18RAP's intracellular signaling cascades and its crosstalk with IL18R1.

Customer Reviews (3)

Write a review
Reviews
02/09/2021

    Effective in signaling studies.

    11/17/2020

      High specificity.

      09/16/2018

        Reliable in co-immunoprecipitation.

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