IL18RAP
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Official Full Name
interleukin 18 receptor accessory protein
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Background
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. -
Synonyms
IL18RAP; Accessory protein like; Accessory protein-like; AcPL; CD218 antigen-like family member B; CD218b; CDw218b; I18RA_HUMAN; IL 18RAcP; IL 1R accessory protein like; IL 1R7; IL 1RAcPL; IL-18 receptor accessory protein; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R accessory protein-like; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RAP; IL18Rbeta; Interleukin 18 receptor accessory protein; Interleukin-1 receptor 7; Interleukin-18 receptor accessory protein; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL18RAP Related Gene Family
IL18RAP involved in several pathways and played different roles in them. We selected most pathways IL18RAP participated on our site, such as Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18RAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | BMPR2A;IFNA17;KITB;GM2506;Fasl;CTF1;LEPR;MPL;BMPR1BA |
| Inflammatory bowel disease (IBD) | HLA-DQB1;TLR2;IL21;IL23R;HLA-DRB4;IL1A;STAT6;IL12B;IL17F |
IL18RAP has several biochemical functions, for example, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18RAP itself. We selected most functions IL18RAP had, and list some proteins which have the same functions with IL18RAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | PAQR3A;TNFRSF25;GFRA2A;MED24;TREM1;MCC;TACSTD2;KLRK1;KLRB1B |
IL18RAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18RAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18RAP.
- Q&As
- Reviews
Q&As (10)
Ask a questionRT-qPCR, immunohistochemistry, and single-cell RNA sequencing characterize IL18RAP expression levels and regulation in diverse cellular contexts.
Animal models, patient samples, and therapeutic interventions elucidate IL18RAP's involvement in immune-related disorders and its potential as a therapeutic target.
Isoform-specific knockdown, mutagenesis, and functional assays delineate IL18RAP isoforms' distinct roles in modulating IL18-mediated responses.
Co-immunoprecipitation assays, FRET studies, and biophysical techniques characterize IL18RAP's interactions with IL18 and IL18R1 partners.
Mass spectrometry, mutagenesis, and functional assays investigate the impact of post-translational modifications on IL18RAP's conformation and function.
Surface plasmon resonance, bio-layer interferometry, and surface plasmon-enhanced fluorescence assays quantify IL18RAP's binding kinetics to IL18 and IL18R1.
siRNA knockdown, CRISPR/Cas9-mediated knockout, and transgenic models unravel IL18RAP's physiological roles and contributions to IL18 signaling.
Single-molecule imaging, super-resolution microscopy, and live-cell imaging visualize the dynamic assembly of IL18 receptor complexes involving IL18RAP.
X-ray crystallography, NMR spectroscopy, and computational modeling reveal IL18RAP's structural interactions with IL18 and IL18R1 domains.
Phosphoprotein analysis, pathway-specific inhibitors, and functional assays dissect IL18RAP's intracellular signaling cascades and its crosstalk with IL18R1.
Customer Reviews (3)
Write a reviewEffective in signaling studies. -
High specificity. -
Reliable in co-immunoprecipitation. -
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