Active Recombinant Human IL18RAP Protein, Fc Chimera
|Product Overview :||Recombinant Human IL18RAP (Accession # O95256), fused with , was produced in Mouse myeloma cell line, NS0-derived.|
- Gene Information
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|Source :||Mammalian cells|
|Predicted N Terminal :||Phe20|
|Form :||Lyophilized from a 0.2 µm filtered solution in PBS.|
|Bio-activity :||Measured by its ability to inhibit the IL-18-induced response of KG-1 human acute myelogenous leukemia cells in the presence of soluble Recombinant Human IL-18 R alpha/IL-1 R5 Fc Chimera.The ED50 for this effect is typically 2 - 6 µg/mL in the presence of 30 µg/mL of soluble IL-18 R alpha/Fc and 40 ng/mL of human IL-18.|
|Molecular Mass :||Recombinant Human IL18RAP, Fc Chimera has a calculated MW of 65.1 kDa (monomer). In SDS-PAGE migrates as 90-100 kDa, reducing conditions.|
|Purity :||>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.|
|Storage :||Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).|
|Reconstitution :||Reconstitute at 100 µg/mL 4 mM HCl containing at least 0.1% human or bovine serum albumin.|
|Gene Name :||IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens ]|
|Official Symbol :||IL18RAP|
|Synonyms :||IL18RAP; interleukin 18 receptor accessory protein; interleukin-18 receptor accessory protein; AcPL; CD218b; IL-1R7; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta; IL-18 receptor beta; interleukin-1 receptor 7; interleukin-18 receptor beta; IL-18 receptor accessory protein; CD218 antigen-like family member B; ACPL; IL18RB; CDw218b; MGC120589; MGC120590;|
|Gene ID :||8807|
|mRNA Refseq :||NM_003853|
|Protein Refseq :||NP_003844|
|UniProt ID :||O95256|
|Chromosome Location :||2q12.1|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
RT-qPCR, immunohistochemistry, and single-cell RNA sequencing characterize IL18RAP expression levels and regulation in diverse cellular contexts.
Animal models, patient samples, and therapeutic interventions elucidate IL18RAP's involvement in immune-related disorders and its potential as a therapeutic target.
Isoform-specific knockdown, mutagenesis, and functional assays delineate IL18RAP isoforms' distinct roles in modulating IL18-mediated responses.
Co-immunoprecipitation assays, FRET studies, and biophysical techniques characterize IL18RAP's interactions with IL18 and IL18R1 partners.
Mass spectrometry, mutagenesis, and functional assays investigate the impact of post-translational modifications on IL18RAP's conformation and function.
Surface plasmon resonance, bio-layer interferometry, and surface plasmon-enhanced fluorescence assays quantify IL18RAP's binding kinetics to IL18 and IL18R1.
siRNA knockdown, CRISPR/Cas9-mediated knockout, and transgenic models unravel IL18RAP's physiological roles and contributions to IL18 signaling.
Single-molecule imaging, super-resolution microscopy, and live-cell imaging visualize the dynamic assembly of IL18 receptor complexes involving IL18RAP.
X-ray crystallography, NMR spectroscopy, and computational modeling reveal IL18RAP's structural interactions with IL18 and IL18R1 domains.
Phosphoprotein analysis, pathway-specific inhibitors, and functional assays dissect IL18RAP's intracellular signaling cascades and its crosstalk with IL18R1.
Customer Reviews (3)Write a review
Effective in signaling studies. -
High specificity. -
Reliable in co-immunoprecipitation. -
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