Recombinant Human Interleukin 18 Receptor Accessory Protein, Fc-His

• Cat.No.: IL18RAP-2255H
• Product Overview: Recombinant Human Interleukin 18 Receptor Accessory encoding the human IL18RAP (Met 1-Arg 356) was fused with the His-tagged Fc region of human IgG1 at the C- terminus. It is expressed inHuman Cells.

Specification

• Species: Human
• Source: Human Cells
• Tag: Fc
• Protein Length: 1-356 a.a.
• Description: Interleukin 18 receptor accessory protein, also known as IL18RAP, IL1R7 and CDw218b, is a single-pass type I membrane protein. It is member of the interleukin-1 receptor family. IL18RAP contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. IL18RAP is strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon. It is not expressed in any other tissue tested. IL18RAP is also strongly expressed in T-cells polarized with IL12 and specifically coexpressed with IL18R1 in Th1 cells.
• Purity: >95 % as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70⁰C.
• Predicted N Terminal: Phe 20.
• Molecular Mass: The recombinant human IL18RAP /Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 575 amino acids and has a calculated molecular mass of 65.2 KDa. As a result of glycosylation, the apparent molecular mass of rhIL18RAP/Fc monomer is approximately 80 -90 KDa in reduced SDS-PAGE.
• Formulation: Supplied as a 0.2μm filtered solution of PBS, pH7.4.
• Reconstitution: Follow the instructions on the vial. Centrifuge the vial at 4⁰C before opening to recover the entire contents.
• Storage: Store it under sterile conditions at -70⁰C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens ]
• Synonyms: IL18RAP; interleukin 18 receptor accessory protein; ACPL; CD218b; IL18RB; CDw218b; MGC120589; MGC120590; IL-18 receptor beta; accessory protein-like; AcPL; IL-18RAcP; IL-18Rbeta; IL-1R7; IL-1RAcPL; OTTHUMP00000161337; CD218 antigen-like family member B; CD218b antigen; IL-18 receptor accessory protein; IL-1R accessory protein-like
• Gene ID: 8807
• mRNA Refseq: NM_003853
• Protein Refseq: NP_003844
• MIM: 604509
• UniProt ID: O95256
• Chromosome Location: 2q12
• Pathway: Cytokine-cytokine receptor interaction
• Function: transmembrane receptor activity