Recombinant Human Interleukin 18 Receptor Accessory Protein, Fc-His IL18RAP-2255H

Recombinant Human Interleukin 18 Receptor Accessory Protein, Fc-His

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Cat.No. : IL18RAP-2255H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human Interleukin 18 Receptor Accessory encoding the human IL18RAP (Met 1-Arg 356) was fused with the His-tagged Fc region of human IgG1 at the C- terminus. It is expressed inHuman Cells.
Description : Interleukin 18 receptor accessory protein, also known as IL18RAP, IL1R7 and CDw218b, is a single-pass type I membrane protein. It is member of the interleukin-1 receptor family. IL18RAP contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. IL18RAP is strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon. It is not expressed in any other tissue tested. IL18RAP is also strongly expressed in T-cells polarized with IL12 and specifically coexpressed with IL18R1 in Th1 cells.
Source : Human Cells.
Purity : >95 % as determined by SDS-PAGE.
Endotoxin : < 1.0 EU per 1μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -700C.
Predicted N Terminal : Phe 20.
Molecular Mass : The recombinant human IL18RAP /Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 575 amino acids and has a calculated molecular mass of 65.2 KDa. As a result of glycosylation, the apparent molecular mass of rhIL18RAP/Fc monomer is approximately 80 -90 KDa in reduced SDS-PAGE.
Formulation : Supplied as a 0.2μm filtered solution of PBS, pH7.4.
Reconstitution : Follow the instructions on the vial. Centrifuge the vial at 40C before opening to recover the entire contents.
Storage : Store it under sterile conditions at -700C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens ]
Synonyms : IL18RAP; interleukin 18 receptor accessory protein; ACPL; CD218b; IL18RB; CDw218b; MGC120589; MGC120590; IL-18 receptor beta; accessory protein-like; AcPL; IL-18RAcP; IL-18Rbeta; IL-1R7; IL-1RAcPL; OTTHUMP00000161337; CD218 antigen-like family member B; CD218b antigen; IL-18 receptor accessory protein; IL-1R accessory protein-like
Gene ID : 8807
mRNA Refseq : NM_003853
Protein Refseq : NP_003844
MIM : 604509
UniProt ID : O95256
Chromosome Location : 2q12
Pathway : Cytokine-cytokine receptor interaction
Function : transmembrane receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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