Recombinant Cynomolgus IL18RAP Protein, hFc-tagged

• Cat.No.: IL18RAP-59C
• Product Overview: Recombinant Cynomolgus IL18RAP Protein, fused to hFc-tag, was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
• Source: HEK293
• Species: Human
• Tag: hFc
• Form: 50 mM Tris, 300 mM NaCl, pH8.5.
• Molecular Mass: 66 kDa
• AA Sequence: FNISGCSTKKLLWAYSTRSEEEFIL FCDLPEPQKSHFCHRSQLSPTQVPD HLPFTDSKDLPDVQWYRQPSNGDPL EDIRKSYPHIIQDKCTLRFLTPGVN NTGSYICRPKMIKSPYDVACCVKMI LEVKPQSNASCENSASHKQDLLLGS TGSISCPSLSCQSDAQSPEVTWYKN GKLLSMTRSNRIVVDEVYIYHQGTY VCDYTQSDTASSWTVRAVVQVRTIV GDTKLKPDILDPVESTLEVELGKPL TISCKARFGFERVFNPVMKWYIKDA DLEWEVSVPEAKSIKSTLKDEIIER NIILEKVTQRDLRRTFVCFVQNSIG NTTQSVQLKEKRGVVEPKSSDKTHT CPPCPAPELLGGPSVFLFPPKPKDT LMISRTPEVTCVVVDVSHEDPEVKF NWYVDGVEVHNAKTKPREEQYNSTY RVVSVLTVLHQDWLNGKEYKCKVSN KALPAPIEKTISKAKGQPREPQVYT LPPSRDELTKNQVSLTCLVKGFYPS DIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSKLTVDKSRWQQGNVFSC SVMHEALHNHYTQKSLSLSPGK
• Endotoxin: ＜1EU/ug
• Purity: >90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.94 mg/ml

Gene Information

• Gene Name: IL18RAP interleukin 18 receptor accessory protein [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: IL18RAP
• Synonyms: ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
• Gene ID: 712046
• mRNA Refseq: XM_015113031
• Protein Refseq: XP_014968517
• UniProt ID: H2QIG7