Recombinant Human IL18RAP Protein, Fc/His-tagged
|Product Overview :||Recombinant Human IL18RAP fused with Fc/His tag at C-terminal was expressed in HEK293 cells.|
- Gene Information
- Related Products
|Description :||The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.|
|Source :||HEK293 cells|
|Form :||Lyophilized from a 0.2 µM filtered solution of 20mM PB, 150mM NaCl, pH7.2|
|Molecular Mass :||66.4kD|
|AA Sequence :||FNISGCSTKKLLWTYSTRSEEEFVL FCDLPEPQKSHFCHRNRLSPKQVPE HLPFMGSNDLSDVQWYQQPSNGDPL EDIRKSYPHIIQDKCTLHFLTPGVN NSGSYICRPKMIKSPYDVACCVKMI LEVKPQTNASCEYSASHKQDLLLGS TGSISCPSLSCQSDAQSPAVTWYKN GKLLSVERSNRIVVDEVYDYHQGTY VCDYTQSDTVSSWTVRAVVQVRTIV GDTKLKPDILDPVEDTLEVELGKPL TISCKARFGFERVFNPVIKWYIKDS DLEWEVSVPEAKSIKSTLKDEIIER NIILEKVTQRDLRRKFVCFVQNSIG NTTQSVQLKEKRVDDIEGRMDEPKS CDKTHTCPPCPAPELLGGPSVFLFP PKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREE QYNSTYRVVSVLTVLHQDWLNGKEY KCKVSNKALPAPIEKTISKAKGQPR EPQVYTLPPSREEMTKNQVSLTCLV KGFYPSDIAVEWESNGQPENNYKTT PPVLDSDGSFFLYSKLTVDKSRWQQ GNVFSCSVMHEALHNHYTQKSLSLS PGKHHHHHH|
|Endotoxin :||Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).|
|Purity :||>95% as determined by SDS-PAGE and Coomassie blue staining|
|Concentration :||Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.|
|Gene Name :||IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens ]|
|Official Symbol :||IL18RAP|
|Synonyms :||IL18RAP; interleukin 18 receptor accessory protein; interleukin-18 receptor accessory protein; AcPL; CD218b; IL-1R7; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta; IL-18 receptor beta; interleukin-1 receptor 7; interleukin-18 receptor beta; IL-18 receptor accessory protein; CD218 antigen-like family member B; ACPL; IL18RB; CDw218b; MGC120589; MGC120590;|
|Gene ID :||8807|
|mRNA Refseq :||NM_003853|
|Protein Refseq :||NP_003844|
|UniProt ID :||O95256|
|◆ Recombinant Protein|
|IL18RAP-97H||Recombinant Human IL18RAP Protein, His (Fc)-Avi-tagged||+Inquiry|
|IL18RAP-157H||Recombinant Human IL18RAP Protein, His-tagged||+Inquiry|
|IL18RAP-17H||Recombinant Human IL18RAP Protein, hIgG/His-tagged||+Inquiry|
|IL18RAP-0681H||Recombinant Human IL18RAP Protein (Phe20-Arg356), N-His tagged||+Inquiry|
|IL18RAP-8835C||Recombinant Rhesus IL18RAP protein, hFc-tagged||+Inquiry|
|IL18RAP-2602HCL||Recombinant Human IL18RAP cell lysate||+Inquiry|
|IL18RAP-1353CCL||Recombinant Cynomolgus IL18RAP cell lysate||+Inquiry|
|IL18RAP-001MCL||Recombinant Mouse IL18RAP cell lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
RT-qPCR, immunohistochemistry, and single-cell RNA sequencing characterize IL18RAP expression levels and regulation in diverse cellular contexts.
Animal models, patient samples, and therapeutic interventions elucidate IL18RAP's involvement in immune-related disorders and its potential as a therapeutic target.
Isoform-specific knockdown, mutagenesis, and functional assays delineate IL18RAP isoforms' distinct roles in modulating IL18-mediated responses.
Co-immunoprecipitation assays, FRET studies, and biophysical techniques characterize IL18RAP's interactions with IL18 and IL18R1 partners.
Mass spectrometry, mutagenesis, and functional assays investigate the impact of post-translational modifications on IL18RAP's conformation and function.
Surface plasmon resonance, bio-layer interferometry, and surface plasmon-enhanced fluorescence assays quantify IL18RAP's binding kinetics to IL18 and IL18R1.
siRNA knockdown, CRISPR/Cas9-mediated knockout, and transgenic models unravel IL18RAP's physiological roles and contributions to IL18 signaling.
Single-molecule imaging, super-resolution microscopy, and live-cell imaging visualize the dynamic assembly of IL18 receptor complexes involving IL18RAP.
X-ray crystallography, NMR spectroscopy, and computational modeling reveal IL18RAP's structural interactions with IL18 and IL18R1 domains.
Phosphoprotein analysis, pathway-specific inhibitors, and functional assays dissect IL18RAP's intracellular signaling cascades and its crosstalk with IL18R1.
Customer Reviews (3)Write a review
Effective in signaling studies. -
High specificity. -
Reliable in co-immunoprecipitation. -
Ask a Question for All IL18RAP Products
Required fields are marked with *
My Review for All IL18RAP Products
Required fields are marked with *