- Cynomolgus Monkey(1)
- Homo sapiens (Human)(1)
- Human(13)
- Mouse(5)
- Rhesus(2)
Recombinant Human Interleukin 18 Receptor Accessory Protein, Fc-tagged
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Cat.No. : | IL18RAP-1658H Optional Service: Optional requirements on this protein |
Description : | Beta chain of interleukin-18 receptor (IL-18Rbeta) is an accessory protein-like molecule that is required for signaling IL-18 signals through its specific cell surface receptor IL-18R, which comprises two subunits: IL-18Rα and IL-18Rβ. IL-18Rα alone has a weak affinity for IL-18 binding, while the IL-18Rα/β complex has a high affinity. IL-18 Rβ is detected in numerous tissues including lung, spleen, leukocytes and colon. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-18 Rβ is Mr 65.1 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90-100 kDa. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >90% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Biological Activity : | The biological activity of Human IL-18 Rβ was determined byits ability to inhibit IL-18 induced response on KG-1 cells, in the presence of soluble IL-18 Rα/Fc. The expected ED50 for this effect is typically 2 - 6 μg/mL in the presence of 30 μg/mL of soluble IL-18 Rα/Fc and 40 ng/mL of human IL-18. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens ] |
Synonyms : | IL18RAP; interleukin 18 receptor accessory protein; ACPL; CD218b; IL18RB; CDw218b; MGC120589; MGC120590; IL-18 receptor beta; accessory protein-like; AcPL; IL-18RAcP; IL-18Rbeta; IL-1R7; IL-1RAcPL; OTTHUMP00000161337; CD218 antigen-like family member B; CD218b antigen; IL-18 receptor accessory protein; IL-1R accessory protein-like |
Gene ID : | 8807 |
mRNA Refseq : | NM_003853 |
Protein Refseq : | NP_003844 |
MIM : | 604509 |
UniProt ID : | O95256 |
Chromosome Location : | 2q12 |
Pathway : | Cytokine-cytokine receptor interaction |
Function : | transmembrane receptor activity |
◆ Recombinant Protein
IL18RAP-17H | Recombinant Human IL18RAP Protein, hIgG/His-tagged | +Inquiry |
IL18RAP-1073H | Active Recombinant Human IL18RAP Protein, Fc Chimera | +Inquiry |
IL18RAP-881H | Recombinant Human IL18RAP Protein, Fc/His-tagged | +Inquiry |
IL18RAP-59C | Recombinant Cynomolgus IL18RAP Protein, hFc-tagged | +Inquiry |
IL18RAP-8836C | Recombinant Rhesus IL18RAP protein, His-tagged | +Inquiry |
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◆ Lysates
IL18RAP-2602HCL | Recombinant Human IL18RAP cell lysate | +Inquiry |
IL18RAP-1353CCL | Recombinant Cynomolgus IL18RAP cell lysate | +Inquiry |
IL18RAP-001MCL | Recombinant Mouse IL18RAP cell lysate | +Inquiry |
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