Recombinant Human Interleukin 18 Receptor Accessory Protein, Fc-tagged IL18RAP-1658H

Recombinant Human Interleukin 18 Receptor Accessory Protein, Fc-tagged

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Cat.No. : IL18RAP-1658H Optional Service: Optional requirements on this protein
Description : Beta chain of interleukin-18 receptor (IL-18Rbeta) is an accessory protein-like molecule that is required for signaling IL-18 signals through its specific cell surface receptor IL-18R, which comprises two subunits: IL-18Rα and IL-18Rβ. IL-18Rα alone has a weak affinity for IL-18 binding, while the IL-18Rα/β complex has a high affinity. IL-18 Rβ is detected in numerous tissues including lung, spleen, leukocytes and colon.
Molecular Weight : The predicted molecular weight of Recombinant Human IL-18 Rβ is Mr 65.1 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90-100 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Human IL-18 Rβ was determined byits ability to inhibit IL-18 induced response on KG-1 cells, in the presence of soluble IL-18 Rα/Fc. The expected ED50 for this effect is typically 2 - 6 μg/mL in the presence of 30 μg/mL of soluble IL-18 Rα/Fc and 40 ng/mL of human IL-18.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens ]
Synonyms : IL18RAP; interleukin 18 receptor accessory protein; ACPL; CD218b; IL18RB; CDw218b; MGC120589; MGC120590; IL-18 receptor beta; accessory protein-like; AcPL; IL-18RAcP; IL-18Rbeta; IL-1R7; IL-1RAcPL; OTTHUMP00000161337; CD218 antigen-like family member B; CD218b antigen; IL-18 receptor accessory protein; IL-1R accessory protein-like
Gene ID : 8807
mRNA Refseq : NM_003853
Protein Refseq : NP_003844
MIM : 604509
UniProt ID : O95256
Chromosome Location : 2q12
Pathway : Cytokine-cytokine receptor interaction
Function : transmembrane receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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