Recombinant Human Interleukin 18 Receptor Accessory Protein, Fc-tagged

• Cat.No.: IL18RAP-1658H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Fc
• Description: Beta chain of interleukin-18 receptor (IL-18Rbeta) is an accessory protein-like molecule that is required for signaling IL-18 signals through its specific cell surface receptor IL-18R, which comprises two subunits: IL-18Rα and IL-18Rβ. IL-18Rα alone has a weak affinity for IL-18 binding, while the IL-18Rα/β complex has a high affinity. IL-18 Rβ is detected in numerous tissues including lung, spleen, leukocytes and colon.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-18 Rβ is Mr 65.1 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90-100 kDa.
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Biological Activity: The biological activity of Human IL-18 Rβ was determined byits ability to inhibit IL-18 induced response on KG-1 cells, in the presence of soluble IL-18 Rα/Fc. The expected ED50 for this effect is typically 2 - 6 μg/mL in the presence of 30 μg/mL of soluble IL-18 Rα/Fc and 40 ng/mL of human IL-18.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens ]
• Synonyms: IL18RAP; interleukin 18 receptor accessory protein; ACPL; CD218b; IL18RB; CDw218b; MGC120589; MGC120590; IL-18 receptor beta; accessory protein-like; AcPL; IL-18RAcP; IL-18Rbeta; IL-1R7; IL-1RAcPL; OTTHUMP00000161337; CD218 antigen-like family member B; CD218b antigen; IL-18 receptor accessory protein; IL-1R accessory protein-like
• Gene ID: 8807
• mRNA Refseq: NM_003853
• Protein Refseq: NP_003844
• MIM: 604509
• UniProt ID: O95256
• Chromosome Location: 2q12
• Pathway: Cytokine-cytokine receptor interaction
• Function: transmembrane receptor activity