Active Recombinant Mouse Il18rap, His-tagged
|Product Overview :||A DNA sequence encoding the mouse IL18RAP (NP_034683.1) (Met1-Glu356) was expressed with a C-terminal polyhistidine tag.|
- Gene Information
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|Source :||Baculovirus-Insect cells|
|Form :||Lyophilized from sterile PBS, pH7.4.|
|Bio-activity :||Measured by its binding ability in a functional ELISA. Immobilized mouse IL18RAP-His at 10 μg/ml (100 μl/well) can bind biotinylated mouse IL18, The EC50 of biotinylated mouse IL18 is 10.6-25.0 μg/ml.|
|Molecular Mass :||The recombinant mouse IL18RAP comprises 348 amino acids and has a predicted molecular mass of 40.1 kDa. The apparent molecular mass of the protein is approximately 44 kDa in SDS-PAGE under reducing conditions.|
|Protein length :||Met1-Glu356|
|Endotoxin :||< 1.0 eu per μg of the protein as determined by the LAL method.|
|Purity :||>95 % as determined by SDS-PAGE|
|Stability :||Samples are stable for up to twelve months from date of receipt at -70℃|
|Storage :||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution :||Hardcopy of COA with reconstitution instruction is sent along with the products.|
|Gene Name :||Il18rap interleukin 18 receptor accessory protein [ Mus musculus ]|
|Official Symbol :||Il18rap|
|Synonyms :||IL18RAP; interleukin 18 receptor accessory protein; interleukin-18 receptor accessory protein; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta; AcPL accessory protein-like); interleukin-18 receptor beta; IL-18 receptor accessory protein; CD218 antigen-like family member B;|
|Gene ID :||16174|
|mRNA Refseq :||NM_010553|
|Protein Refseq :||NP_034683|
|Pathway :||Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;|
|Function :||interleukin-1 receptor activity; receptor activity; transmembrane signaling receptor activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
RT-qPCR, immunohistochemistry, and single-cell RNA sequencing characterize IL18RAP expression levels and regulation in diverse cellular contexts.
Animal models, patient samples, and therapeutic interventions elucidate IL18RAP's involvement in immune-related disorders and its potential as a therapeutic target.
Isoform-specific knockdown, mutagenesis, and functional assays delineate IL18RAP isoforms' distinct roles in modulating IL18-mediated responses.
Co-immunoprecipitation assays, FRET studies, and biophysical techniques characterize IL18RAP's interactions with IL18 and IL18R1 partners.
Mass spectrometry, mutagenesis, and functional assays investigate the impact of post-translational modifications on IL18RAP's conformation and function.
Surface plasmon resonance, bio-layer interferometry, and surface plasmon-enhanced fluorescence assays quantify IL18RAP's binding kinetics to IL18 and IL18R1.
siRNA knockdown, CRISPR/Cas9-mediated knockout, and transgenic models unravel IL18RAP's physiological roles and contributions to IL18 signaling.
Single-molecule imaging, super-resolution microscopy, and live-cell imaging visualize the dynamic assembly of IL18 receptor complexes involving IL18RAP.
X-ray crystallography, NMR spectroscopy, and computational modeling reveal IL18RAP's structural interactions with IL18 and IL18R1 domains.
Phosphoprotein analysis, pathway-specific inhibitors, and functional assays dissect IL18RAP's intracellular signaling cascades and its crosstalk with IL18R1.
Customer Reviews (3)Write a review
Effective in signaling studies. -
High specificity. -
Reliable in co-immunoprecipitation. -
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