Recombinant Human IL18RAP Protein, hIgG/His-tagged

Cat.No. : IL18RAP-17H
Product Overview : Recombinant human IL-18 R beta/IL-1 R7 protein (20-356aa, 576aa), fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Description : The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Source : Insect cell
Species : Human
Tag : hIgG/His
Form : Liquid
Molecular Mass : 65.4 kDa
Protein length : 20-356
AA Sequence : FNISGCSTKKLLWTYSTRSEEEFVL FCDLPEPQKSHFCHRNRLSPKQVPE HLPFMGSNDLSDVQWYQQPSNGDPL EDIRKSYPHIIQDKCTLHFLTPGVN NSGSYICRPKMIKSPYDVACCVKMI LEVKPQTNASCEYSASHKQDLLLGS TGSISCPSLSCQSDAQSPAVTWYKN GKLLSVERSNRIVVDEVYDYHQGTY VCDYTQSDTVSSWTVRAVVQVRTIV GDTKLKPDILDPVEDTLEVELGKPL TISCKARFGFERVFNPVIKWYIKDS DLEWEVSVPEAKSIKSTLKDEIIER NIILEKVTQRDLRRKFVCFVQNSIG NTTQSVQLKEKR
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 90% by SDS-PAGE
Applications : SDS-PAGE
Storage : Can be stored at 2 to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/mL (determined by absorbance at 280nm)
Storage Buffer : Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Name : IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens (human) ]
Official Symbol : IL18RAP
Synonyms : IL18RAP; interleukin 18 receptor accessory protein; ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta; interleukin-18 receptor accessory protein; CD218 antigen-like family member B; IL-18 receptor accessory protein; IL-18 receptor beta; cluster of differentiation w218b; interleukin-1 receptor 7; interleukin-18 receptor beta; EC 3.2.2.6
Gene ID : 8807
mRNA Refseq : NM_003853
Protein Refseq : NP_003844
MIM : 604509
UniProt ID : O95256

Products Types

◆ Recombinant Protein
IL18RAP-157H Recombinant Human IL18RAP Protein, His-tagged +Inquiry
IL18RAP-97H Recombinant Human IL18RAP Protein, His (Fc)-Avi-tagged +Inquiry
IL18RAP-1863H Recombinant Human IL18RAP protein, His & Avi-tagged, Biotinylated +Inquiry
IL18RAP-922M Active Recombinant Mouse IL18RAP Protein, His-tagged +Inquiry
IL18RAP-880H Recombinant Human IL18RAP Protein, His-tagged +Inquiry

See All IL18RAP Recombinant Protein

◆ Lysates
IL18RAP-001MCL Recombinant Mouse IL18RAP cell lysate +Inquiry
IL18RAP-2602HCL Recombinant Human IL18RAP cell lysate +Inquiry
IL18RAP-1353CCL Recombinant Cynomolgus IL18RAP cell lysate +Inquiry

See All IL18RAP Lysates

Related Gene

IL10 IL10RA IL10RB IL11 IL11RA Il11ra1 IL12 IL12A IL12B IL12RB1 IL13 IL13RA1 IL13RA2 IL15 IL15RA IL16 IL17A IL17B Il17c IL17D Il17f IL17RA IL17RD IL18 IL18BP IL18R1 IL18RAP Il19 Il1a IL1B IL1F10 IL1R1 Il1r2 IL1RAP IL1RAPL1 IL1RAPL2 IL1RL1 IL1RL2 Il1rn IL2 Il20 IL20RA IL21 IL21R IL22 IL22RA1 IL22RA2 IL23A IL24 Il25 IL27 IL27RA IL28A Il28b IL29 IL2RA IL2RB Il2rg IL3 IL31 IL32 Il33 Il34 IL3RA IL4 IL4R Il4ra Il5 IL5RA Il6 IL6R Il6ra IL6ST Il7 IL7R IL8 IL9 IL36A Il12rb2 IL17RB IL23R IL26 IL31RA IL36B IL36G IL36RN IL37 IL9R IL17RC IL17RE IL28RA IL4I1 IL20RB Il11ra2 IL7RA Il23a&Il12b

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What experimental methods are commonly employed to study the expression patterns and regulation of IL18RAP across different cell types and conditions? 12/01/2021

RT-qPCR, immunohistochemistry, and single-cell RNA sequencing characterize IL18RAP expression levels and regulation in diverse cellular contexts.

What techniques are utilized to investigate the role of IL18RAP in immune responses, inflammation, and diseases, and how do researchers assess its potential as a therapeutic target? 03/15/2021

Animal models, patient samples, and therapeutic interventions elucidate IL18RAP's involvement in immune-related disorders and its potential as a therapeutic target.

Could you provide insights into the experimental approaches used to explore the functional effects of IL18RAP isoforms and their specific contributions to IL18 signaling? 12/21/2020

Isoform-specific knockdown, mutagenesis, and functional assays delineate IL18RAP isoforms' distinct roles in modulating IL18-mediated responses.

How are co-immunoprecipitation, fluorescence resonance energy transfer (FRET), and biophysical assays applied to characterize the interactions between IL18RAP, IL18, and IL18R1? 12/20/2019

Co-immunoprecipitation assays, FRET studies, and biophysical techniques characterize IL18RAP's interactions with IL18 and IL18R1 partners.

What experimental methods are used to elucidate the effects of post-translational modifications, such as glycosylation, on IL18RAP's structure and function? 05/18/2019

Mass spectrometry, mutagenesis, and functional assays investigate the impact of post-translational modifications on IL18RAP's conformation and function.

How do researchers experimentally determine the binding affinity and kinetics of IL18RAP to IL18 and IL18R1, considering its pivotal role in forming the IL18 receptor complex? 11/17/2018

Surface plasmon resonance, bio-layer interferometry, and surface plasmon-enhanced fluorescence assays quantify IL18RAP's binding kinetics to IL18 and IL18R1.

Can you explain the use of knockdown, knockout, and gene editing techniques to uncover the physiological importance of IL18RAP in mediating IL18 signaling? 08/10/2018

siRNA knockdown, CRISPR/Cas9-mediated knockout, and transgenic models unravel IL18RAP's physiological roles and contributions to IL18 signaling.

How are advanced imaging techniques, such as single-molecule imaging and super-resolution microscopy, utilized to visualize the dynamic assembly of the IL18 receptor complex involving IL18RAP? 11/05/2017

Single-molecule imaging, super-resolution microscopy, and live-cell imaging visualize the dynamic assembly of IL18 receptor complexes involving IL18RAP.

Can you elaborate on the strategies used to investigate the structural features of IL18RAP's interaction interfaces with IL18 and IL18R1, and how these interfaces contribute to receptor activation? 10/29/2017

X-ray crystallography, NMR spectroscopy, and computational modeling reveal IL18RAP's structural interactions with IL18 and IL18R1 domains.

How do researchers dissect the intracellular signaling pathways triggered by IL18RAP upon binding to IL18 and its collaboration with IL18R1? 10/09/2017

Phosphoprotein analysis, pathway-specific inhibitors, and functional assays dissect IL18RAP's intracellular signaling cascades and its crosstalk with IL18R1.

Customer Reviews (3)

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Reviews
02/09/2021

    Effective in signaling studies. -

    11/17/2020

      High specificity. -

      09/16/2018

        Reliable in co-immunoprecipitation. -

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