Recombinant Human IL18RAP Protein, His-tagged
|Product Overview :||Recombinant Human IL18RAP Protein with His tag was expressed in E. coli.|
- Gene Information
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|Description :||Interleukin-18 (IL-18) has been identified as a molecule that induces IFN-γ production and enhances NK cell cytotoxicity. IL-18 receptor (IL-18R) is a type I membrane protein present in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta and heart, and absent from brain, skeletal muscle, pancreas and kidney. IL-18R is present in Hodgkin’s disease cell lines, and does not bind IL-1α or IL-1β. The association of IL-18 to IL-18R leads to activation of NFκB. At present two subunits of IL-18R have been characterized: IL-18Rα and IL-18Rβ. IL-18Rα has been described as the ligand-binding chain and IL-18Rβ as the signal-transduction chain.|
|Source :||E. coli|
|Molecular Mass :||~43 kDa|
|AA Sequence :||MFNISGCSTKKLLWTYSTRSEEEFV LFCDLPEPQKSHFCHRNRLSPKQVP EHLPFMGSNDLSDVQWYQQPSNGDP LEDIRKSYPHIIQDKCTLHFLTPGV NNSGSYICRPKMIKSPYDVACCVKM ILEVKPQTNASCEYSASHKQDLLLG STGSISCPSLSCQSDAQSPAVTWYK NGKLLSVERSNRIVVDEVYDYHQGT YVCDYTQSDTVSSWTVRAVVQVRTI VGDTKLKPDILDPVEDTLEVELGKP LTISCKARFGFERVFNPVIKWYIKD SDLEWEVSVPEAKSIKSTLKDEIIE RNIILEKVTQRDLRRKFVCFVQNSI GNTTQSVQLKEKR|
|Purity :||Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).|
|Notes :||For research use only, not for use in diagnostic procedure.|
|Storage :||Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.|
|Storage Buffer :||PBS, 4M Urea, pH7.4|
|Gene Name :||IL18RAP interleukin 18 receptor accessory protein [ Homo sapiens (human) ]|
|Official Symbol :||IL18RAP|
|Synonyms :||IL18RAP; interleukin 18 receptor accessory protein; interleukin-18 receptor accessory protein; AcPL; CD218b; IL-1R7; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta; IL-18 receptor beta; interleukin-1 receptor 7; interleukin-18 receptor beta; IL-18 receptor accessory protein; CD218 antigen-like family member B; ACPL; IL18RB; CDw218b; MGC120589; MGC120590;|
|Gene ID :||8807|
|mRNA Refseq :||NM_003853|
|Protein Refseq :||NP_003844|
|UniProt ID :||O95256|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
RT-qPCR, immunohistochemistry, and single-cell RNA sequencing characterize IL18RAP expression levels and regulation in diverse cellular contexts.
Animal models, patient samples, and therapeutic interventions elucidate IL18RAP's involvement in immune-related disorders and its potential as a therapeutic target.
Isoform-specific knockdown, mutagenesis, and functional assays delineate IL18RAP isoforms' distinct roles in modulating IL18-mediated responses.
Co-immunoprecipitation assays, FRET studies, and biophysical techniques characterize IL18RAP's interactions with IL18 and IL18R1 partners.
Mass spectrometry, mutagenesis, and functional assays investigate the impact of post-translational modifications on IL18RAP's conformation and function.
Surface plasmon resonance, bio-layer interferometry, and surface plasmon-enhanced fluorescence assays quantify IL18RAP's binding kinetics to IL18 and IL18R1.
siRNA knockdown, CRISPR/Cas9-mediated knockout, and transgenic models unravel IL18RAP's physiological roles and contributions to IL18 signaling.
Single-molecule imaging, super-resolution microscopy, and live-cell imaging visualize the dynamic assembly of IL18 receptor complexes involving IL18RAP.
X-ray crystallography, NMR spectroscopy, and computational modeling reveal IL18RAP's structural interactions with IL18 and IL18R1 domains.
Phosphoprotein analysis, pathway-specific inhibitors, and functional assays dissect IL18RAP's intracellular signaling cascades and its crosstalk with IL18R1.
Customer Reviews (3)Write a review
Effective in signaling studies. -
High specificity. -
Reliable in co-immunoprecipitation. -
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