Il19

  • Official Full Name

    interleukin 19

  • Overview

    The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
  • Synonyms

    IL19; interleukin 19; interleukin-19; IL 10C; IL 19; MDA1; melanoma differentiation associated protein like protein; NG.1; ZMDA1; OTTHUMP00000034568; OTTHUMP00000216804; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein; IL-10C;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cells
  • Insect Cells
  • Mammalian cells
  • Yeast
  • C
  • His
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • Met
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL19-406H Active Recombinant Human IL19, Met-tagged E.coli Met
Human IL19-245H Active Recombinant Human IL19 protein Mammalian cells N/A
Human IL19-499H Active Recombinant Human Interleukin 19 E.coli N/A
Human IL19-38H Recombinant Human IL-19 Yeast N/A
Human IL19-482H Active Recombinant Human IL19 protein, His-tagged HEK293 His Met1-Ala177
Human IL19-14165H Recombinant Human IL19, His-tagged E.coli His 63-215a.a.
Human IL19-130H Recombinant Human IL19 protein E.coli N/A 153
Human IL19-481H Active Recombinant Human IL19 protein, His-tagged Insect Cells His Met1-Ala177
Human IL19-5242HCL Recombinant Human IL19 293 Cell Lysate HEK293 N/A
Human IL19-1470H Recombinant Human IL19 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL19-151H Recombinant Human IL19 Protein, His-tagged Human Cells His
Human IL19-4332HG Active GMP Recombinant Human IL19 protein E.coli N/A
Human IL19-1014H Recombinant Human IL19 Protein, His-tagged CHO N-His Leu25-Ala177
Human IL19-03H Recombinant Human IL19 Protein, His-tagged HEK293 His 25-177aa
Human IL19-156H Recombinant Active Human IL19 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL19-146H Recombinant Human IL19 Protein E.coli
Human IL19-4438H Recombinant Human IL19 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL19-4438H-B Recombinant Human IL19 Protein Pre-coupled Magnetic Beads HEK293
Human IL19-3497H Recombinant Human IL19 Protein (Leu25-Ala177), N-His tagged E.coli N-His Leu25-Ala177
Human IL19-138H Active Recombinant Human IL19 Protein (Leu25-Ala177), C-His tagged, Animal-free, Carrier-free E.coli C-His Leu25-Ala177
Human IL19-4228H Recombinant Human IL19 Protein (Met1-Ala177), C-His tagged Mammalian cells C-His Met1-Ala177
Mouse Il19-01M Active Recombinant Mouse Il19 Protein, His-Tagged E.coli His
Mouse Il19-72M Recombinant Mouse Il19 protein E.coli N/A 152
Mouse Il19-367I Active Recombinant Mouse Il19 Protein (153 aa) E.coli 153
Mouse Il19-150M Active Recombinant Mouse Il19 Protein (Leu25-Ala176), C-His tagged, Animal-free, Carrier-free E.coli C-His Leu25-Ala176
Mouse Il19-1015M Recombinant Mouse Il19 Protein, His-tagged HEK293F N-His Leu25-Ala176
Mouse IL19-147M Recombinant Mouse IL19 Protein E.coli
Mouse Il19-157M Recombinant Active Mouse IL19 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Il19-3503M Recombinant Mouse Il19 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Il19-1668R Recombinant Rat Il19 Protein, His-tagged E.coli N-His Arg26-Thr177
Rat Il19-1016R Recombinant Rat Il19 Protein, His-tagged HEK293F N-His Arg26-Thr177
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Il19 involved in several pathways and played different roles in them. We selected most pathways Il19 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCTF1;ACVR2AA;Il4ra;IL13;CCL4;TGFB1A;GM13305;PDGFB;AMHR2
Jak-STAT signaling pathwayPTPN11;IL21;SOCS1A;IL12RB1;IL2RG;Gh;IFNB1;AKT3A;CSH

Il19 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il19 itself. We selected most functions Il19 had, and list some proteins which have the same functions with Il19. You can find most of the proteins on our site.

Function Related Protein
cytokine activityCCL20A.3;IL17D;BMP2;IL34;IFNE;IL17A;Flt3l;CMTM2;IFNA13

Il19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il19 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il19.

Gene Family

IL

Research Area

  • Q&As
  • Reviews

Q&As (10)

Ask a question
How are advanced imaging methods, like confocal microscopy and flow cytometry, applied to visualize IL19-mediated cellular responses and receptor internalization? 11/26/2022

Confocal microscopy and flow cytometry visualize IL19-induced cellular responses and track receptor internalization upon ligand binding.

What methods are employed to explore IL19's effects on immune cell polarization, cytokine secretion, and its potential involvement in chronic inflammatory conditions? 06/28/2022

Functional assays using immune cell cultures and cytokine profiling assays dissect IL19's impact on immune cell polarization and cytokine secretion.

What experimental strategies are utilized to investigate the binding affinities and stoichiometry of IL19 interactions with its cognate receptor IL20RA and potential co-receptor IL20RB? 03/30/2021

Biophysical techniques like surface plasmon resonance and analytical ultracentrifugation quantify IL19's binding to IL20RA and IL20RB and reveal receptor complex composition.

What techniques, such as surface plasmon resonance and isothermal titration calorimetry, are used to quantify IL19's binding kinetics to its receptor complexes? 08/14/2020

Biophysical techniques such as surface plasmon resonance and isothermal titration calorimetry quantify IL19's binding kinetics to its receptor complexes.

Could you elaborate on the use of CRISPR/Cas9-based knockout models and RNA interference to dissect IL19's role in specific cell types and tissues? 01/14/2020

CRISPR/Cas9 knockout models and siRNA-mediated knockdown in specific cell types unravel IL19's cell-specific roles.

What experimental methodologies, including neutralizing antibodies and receptor blockade, are employed to assess IL19's potential as a therapeutic target in inflammatory and autoimmune diseases? 12/18/2018

Neutralizing antibodies, receptor blockade experiments, and in vivo disease models evaluate IL19's suitability as a therapeutic target in inflammatory and autoimmune diseases.

How do researchers employ recombinant protein production techniques to generate bioactive IL19 for in vitro and in vivo functional studies? 11/08/2018

Recombinant protein expression in bacterial or mammalian systems followed by purification allows generation of functional IL19 for various experimental assays.

How are reporter gene assays, chromatin immunoprecipitation, and DNA-protein interaction techniques applied to uncover the transcriptional regulation of IL19 and its downstream targets? 11/03/2018

Reporter gene assays, ChIP, and DNA-protein interaction studies probe IL19's transcriptional regulation and interactions with specific DNA sequences.

How do researchers utilize animal models and patient samples to study IL19's contribution to skin disorders, such as psoriasis, and its therapeutic implications? 04/19/2017

Animal models and patient samples, combined with histopathology and molecular assays, shed light on IL19's involvement in skin disorders and its therapeutic potential.

Can you explain the experimental approaches to elucidate IL19's role in wound healing, tissue repair, and its impact on fibroblast and keratinocyte function? 02/18/2017

Animal wound healing models, in vitro cell migration assays, and co-culture experiments investigate IL19's role in tissue repair and its effects on fibroblast and keratinocyte function.

Customer Reviews (3)

Write a review
Reviews
02/22/2021

    High reproducibility.

    07/11/2020

      Suitable for Western blot.

      04/01/2019

        Effective in cell differentiation.

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