Il19
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Official Full Name
interleukin 19
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Background
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. -
Synonyms
IL19; interleukin 19; interleukin-19; IL 10C; IL 19; MDA1; melanoma differentiation associated protein like protein; NG.1; ZMDA1; OTTHUMP00000034568; OTTHUMP00000216804; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein; IL-10C;
- Involved Pathway
- Protein Function
- Interacting Protein
- Il19 Related Gene Family
- Il19 Related Research Area
Il19 involved in several pathways and played different roles in them. We selected most pathways Il19 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCR6A;TP-1;CCR3;IL18R1;TNFRSF10A;IL20;BMP2;CCL20;LEP |
| Jak-STAT signaling pathway | AOX1;TSLP;IL5;Gh;LEP;IL21R;PIK3R3A;OSM;IFNA10 |
Il19 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il19 itself. We selected most functions Il19 had, and list some proteins which have the same functions with Il19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IFNA2;BMP8A;IL17B;NAMPT;IL32;HMGB1A;GM13289;INHBA;MSTN |
Il19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il19 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il19.
- Q&As
- Reviews
Q&As (10)
Ask a questionConfocal microscopy and flow cytometry visualize IL19-induced cellular responses and track receptor internalization upon ligand binding.
Functional assays using immune cell cultures and cytokine profiling assays dissect IL19's impact on immune cell polarization and cytokine secretion.
Biophysical techniques like surface plasmon resonance and analytical ultracentrifugation quantify IL19's binding to IL20RA and IL20RB and reveal receptor complex composition.
Biophysical techniques such as surface plasmon resonance and isothermal titration calorimetry quantify IL19's binding kinetics to its receptor complexes.
CRISPR/Cas9 knockout models and siRNA-mediated knockdown in specific cell types unravel IL19's cell-specific roles.
Neutralizing antibodies, receptor blockade experiments, and in vivo disease models evaluate IL19's suitability as a therapeutic target in inflammatory and autoimmune diseases.
Recombinant protein expression in bacterial or mammalian systems followed by purification allows generation of functional IL19 for various experimental assays.
Reporter gene assays, ChIP, and DNA-protein interaction studies probe IL19's transcriptional regulation and interactions with specific DNA sequences.
Animal models and patient samples, combined with histopathology and molecular assays, shed light on IL19's involvement in skin disorders and its therapeutic potential.
Animal wound healing models, in vitro cell migration assays, and co-culture experiments investigate IL19's role in tissue repair and its effects on fibroblast and keratinocyte function.
Customer Reviews (3)
Write a reviewHigh reproducibility. -
Suitable for Western blot. -
Effective in cell differentiation. -
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