Recombinant Human IL19 Protein
Cat.No. : | IL19-146H |
Product Overview : | Recombinant Human IL19 Protein without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-19 (IL-19) is a member of the interleukin 10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin 20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-a) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS) stimulation. |
Source : | E. coli |
Species : | Human |
Bio-activity : | No biological activity data is available at this time. |
Molecular Mass : | Monomer, 17.9 kDa (154 aa) |
AA Sequence : | MLRRCLISTDMHHIEESFQEIKRAI QAKDTFPNVTILSTLETLQIIKPLD VCCVTKNLLAFYVDRVFKDHQEPNP KILRKISSIANSFLYMQKTLRQCQE QRQCHCRQEATNATRVIHDNYDQLE VHAAAIKSLGELDVFLAWINKNHEV MFSA |
Endotoxin : | ≤1 EUs/μg, Kinetic LAL |
Purity : | ≥95%, Reducing and Non-Reducing SDS PAGE |
Stability : | 12 months from date of receipt when stored at -20 to -80 centigrade as supplied. 1 month when stored at 4 centigrade after reconstituting as directed. 3 months when stored at -20 to -80 centigrade after reconstituting as directed. |
Storage : | Storage Prior to Reconstitution: -20 centigrade |
Storage Buffer : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) |
Reconstitution : | Sterile water at 0.1 mg/mL |
Shipping : | Room temperature |
Instructions : | Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80 centigrade and avoid repeat freeze thaws. |
Gene Name : | IL19 interleukin 19 [ Homo sapiens (human) ] |
Official Symbol : | IL19 |
Synonyms : | IL19; interleukin 19; interleukin-19; IL 10C; IL 19; MDA1; melanoma differentiation associated protein like protein; NG.1; ZMDA1; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein; IL-10C; |
Gene ID : | 29949 |
mRNA Refseq : | NM_013371 |
Protein Refseq : | NP_037503 |
MIM : | 605687 |
UniProt ID : | Q9UHD0 |
Products Types
◆ Recombinant Protein | ||
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Il19-157M | Recombinant Active Mouse IL19 Protein, His-tagged(C-ter) | +Inquiry |
IL19-1014H | Recombinant Human IL19 Protein, His-tagged | +Inquiry |
IL19-138H | Active Recombinant Human IL19 Protein (Leu25-Ala177), C-His tagged, Animal-free, Carrier-free | +Inquiry |
IL19-156H | Recombinant Active Human IL19 Protein, His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
IL19-5242HCL | Recombinant Human IL19 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionConfocal microscopy and flow cytometry visualize IL19-induced cellular responses and track receptor internalization upon ligand binding.
Functional assays using immune cell cultures and cytokine profiling assays dissect IL19's impact on immune cell polarization and cytokine secretion.
Biophysical techniques like surface plasmon resonance and analytical ultracentrifugation quantify IL19's binding to IL20RA and IL20RB and reveal receptor complex composition.
Biophysical techniques such as surface plasmon resonance and isothermal titration calorimetry quantify IL19's binding kinetics to its receptor complexes.
CRISPR/Cas9 knockout models and siRNA-mediated knockdown in specific cell types unravel IL19's cell-specific roles.
Neutralizing antibodies, receptor blockade experiments, and in vivo disease models evaluate IL19's suitability as a therapeutic target in inflammatory and autoimmune diseases.
Recombinant protein expression in bacterial or mammalian systems followed by purification allows generation of functional IL19 for various experimental assays.
Reporter gene assays, ChIP, and DNA-protein interaction studies probe IL19's transcriptional regulation and interactions with specific DNA sequences.
Animal models and patient samples, combined with histopathology and molecular assays, shed light on IL19's involvement in skin disorders and its therapeutic potential.
Animal wound healing models, in vitro cell migration assays, and co-culture experiments investigate IL19's role in tissue repair and its effects on fibroblast and keratinocyte function.
Customer Reviews (3)
Write a reviewHigh reproducibility.
Suitable for Western blot.
Effective in cell differentiation.
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