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Recombinant Mouse Il19 Protein, His-tagged

Cat.No. : Il19-1015M
Product Overview : Recombinant Mouse Il19 Protein (Leu25-Ala176) with His tag was expressed in 293F.
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  • Gene Information
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Description : Predicted to enable cytokine activity. Involved in negative regulation of low-density lipoprotein particle clearance. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; and reactive oxygen species metabolic process. Predicted to be located in extracellular space. Orthologous to human IL19 (interleukin 19).
Source : HEK293F
Species : Mouse
Tag : N-His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 19.2 kDa; Accurate Molecular Mass: 26-38 kDa
Protein length : Leu25-Ala176
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : Il19 interleukin 19 [ Mus musculus (house mouse) ]
Official Symbol : Il19
Synonyms : IL19; interleukin 19; interleukin-19; IL-19;
Gene ID : 329244
mRNA Refseq : NM_001009940
Protein Refseq : NP_001009940
UniProt ID : Q8CJ70

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How are advanced imaging methods, like confocal microscopy and flow cytometry, applied to visualize IL19-mediated cellular responses and receptor internalization? 11/26/2022

Confocal microscopy and flow cytometry visualize IL19-induced cellular responses and track receptor internalization upon ligand binding.

What methods are employed to explore IL19's effects on immune cell polarization, cytokine secretion, and its potential involvement in chronic inflammatory conditions? 06/28/2022

Functional assays using immune cell cultures and cytokine profiling assays dissect IL19's impact on immune cell polarization and cytokine secretion.

What experimental strategies are utilized to investigate the binding affinities and stoichiometry of IL19 interactions with its cognate receptor IL20RA and potential co-receptor IL20RB? 03/30/2021

Biophysical techniques like surface plasmon resonance and analytical ultracentrifugation quantify IL19's binding to IL20RA and IL20RB and reveal receptor complex composition.

What techniques, such as surface plasmon resonance and isothermal titration calorimetry, are used to quantify IL19's binding kinetics to its receptor complexes? 08/14/2020

Biophysical techniques such as surface plasmon resonance and isothermal titration calorimetry quantify IL19's binding kinetics to its receptor complexes.

Could you elaborate on the use of CRISPR/Cas9-based knockout models and RNA interference to dissect IL19's role in specific cell types and tissues? 01/14/2020

CRISPR/Cas9 knockout models and siRNA-mediated knockdown in specific cell types unravel IL19's cell-specific roles.

What experimental methodologies, including neutralizing antibodies and receptor blockade, are employed to assess IL19's potential as a therapeutic target in inflammatory and autoimmune diseases? 12/18/2018

Neutralizing antibodies, receptor blockade experiments, and in vivo disease models evaluate IL19's suitability as a therapeutic target in inflammatory and autoimmune diseases.

How do researchers employ recombinant protein production techniques to generate bioactive IL19 for in vitro and in vivo functional studies? 11/08/2018

Recombinant protein expression in bacterial or mammalian systems followed by purification allows generation of functional IL19 for various experimental assays.

How are reporter gene assays, chromatin immunoprecipitation, and DNA-protein interaction techniques applied to uncover the transcriptional regulation of IL19 and its downstream targets? 11/03/2018

Reporter gene assays, ChIP, and DNA-protein interaction studies probe IL19's transcriptional regulation and interactions with specific DNA sequences.

How do researchers utilize animal models and patient samples to study IL19's contribution to skin disorders, such as psoriasis, and its therapeutic implications? 04/19/2017

Animal models and patient samples, combined with histopathology and molecular assays, shed light on IL19's involvement in skin disorders and its therapeutic potential.

Can you explain the experimental approaches to elucidate IL19's role in wound healing, tissue repair, and its impact on fibroblast and keratinocyte function? 02/18/2017

Animal wound healing models, in vitro cell migration assays, and co-culture experiments investigate IL19's role in tissue repair and its effects on fibroblast and keratinocyte function.

Customer Reviews (3)

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Reviews
02/22/2021

    High reproducibility.

    07/11/2020

      Suitable for Western blot.

      04/01/2019

        Effective in cell differentiation.

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