Recombinant Human INSR protein(601-750 aa), C-His-tagged

• Cat.No.: INSR-2564H
• Product Overview: Recombinant Human INSR protein(P06213)(601-750 aa), fused with C-terminal His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Protein length: 601-750 aa
• Form: 0.15 M Phosphate buffered saline
• AASequence: DERRTYGAKSDIIYVQTDATNPSVP LDPISVSNSSSQIILKWKPPSDPNG NITHYLVFWERQAEDSELFELDYCL KGLKLPSRTWSPPFESEDSQKHNQS EYEDSAGECCSCPKTDSQILKELEE SSFRKTFEDYLHNVVFVPRKTSSGT
• Storage: Shipped on dry ice. Avoid repeated freeze-thaw cycles. Upon receipt, 2 days when stored at 2 to 8 °C after thawing.
  Up to 12 months when aliquoted and stored at -20 to -80°C.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: INSR insulin receptor [ Homo sapiens ]
• Official Symbol: INSR
• Synonyms: INSR; insulin receptor; CD220; IR; HHF5
• Gene ID: 3643
• mRNA Refseq: NM_000208
• Protein Refseq: NP_000199
• MIM: 147670
• UniProt ID: P06213

Reviews

02/25/2020

The compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.

04/26/2016

The product's support in the form of educational resources positively impacted the learning curve for our researchers.

04/18/2016

The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

Q&As

What impact does malfunction or dysregulation of the insulin receptor (INSR) have on metabolic health?

Malfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.

How does the insulin receptor (INSR) function in regulating glucose metabolism in cells?

INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.

What are the key tissues or cell types where the insulin receptor (INSR) is prominently expressed?

The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.

Are there known genetic variations or mutations in the insulin receptor (INSR) associated with metabolic disorders or insulin resistance?

Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.

In the context of diabetes, what role does the insulin receptor (INSR) play in the development of insulin resistance?

In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.

What is the primary role of the insulin receptor (INSR) protein in cellular processes?

The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.

How does the insulin receptor (INSR) activate downstream signaling pathways in response to insulin binding?

Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.