Recombinant Human INSR
Cat.No. : | INSR-27625TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 999-1362 of Human Insulin Receptor with N-terminal proprietary tag expressed in a Baculovirus expression system, 67 kDa. |
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Description : | After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. |
Tissue specificity : | Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Isoform Long and isoform Short are expressed in the peripheral nerve, kidney, liver, striated m |
Biological activity : | Specific Activity: 43.3 pmol/min/μg.Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA, 0.01% BRIJ- 35 and 200 uM of ATP. Substrate : 4 uM Tyr peptide 1 |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 3 fibronectin type-III domains.Contains 1 protein kinase domain. |
Tag : | Non |
Protein length : | 999-1362 |
Gene Name : | INSR insulin receptor [ Homo sapiens ] |
Official Symbol : | INSR |
Synonyms : | INSR; insulin receptor; CD220; |
Gene ID : | 3643 |
mRNA Refseq : | NM_000208 |
Protein Refseq : | NP_000199 |
MIM : | 147670 |
Uniprot ID : | P06213 |
Chromosome Location : | 19p13.3-p13.2 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; IRS activation, organism-specific biosystem; |
Function : | 3-phosphoinositide-dependent protein kinase binding; ATP binding; GTP binding; PTB domain binding; SH2 domain binding; |
Products Types
◆ Recombinant Protein | ||
INSR-0997H | Recombinant Human INSR Protein (M1-S1382), eGFP, Strep II, 10×His tagged | +Inquiry |
INSR-5093H | Active Recombinant Human INSR Protein, GST-tagged | +Inquiry |
INSR-2565H | Recombinant Human INSR protein(601-940 aa), N-SUMO & C-His-tagged | +Inquiry |
INSR-5092H | Recombinant Human INSR Protein, GST-tagged | +Inquiry |
INSR-2564H | Recombinant Human INSR protein(601-750 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
INSR-2648HCL | Recombinant Human INSR cell lysate | +Inquiry |
INSR-474HCL | Recombinant Human INSR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1607 | INSR Internalization Assay Kit | +Inquiry |
Kit-1605 | U2OS INSR Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.
The product's support in the form of educational resources positively impacted the learning curve for our researchers.
The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.
Q&As (7)
Ask a questionMalfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.
INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.
The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.
Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.
In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.
The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.
Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.
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