Recombinant Human INSR

Cat.No. : INSR-27625TH
Product Overview : Recombinant fragment, corresponding to amino acids 999-1362 of Human Insulin Receptor with N-terminal proprietary tag expressed in a Baculovirus expression system, 67 kDa.
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Description : After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
Tissue specificity : Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Isoform Long and isoform Short are expressed in the peripheral nerve, kidney, liver, striated m
Biological activity : Specific Activity: 43.3 pmol/min/μg.Assay condition: The enzyme reaction was carried out for 1h at room temperature in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EDTA, 0.01% BRIJ- 35 and 200 uM of ATP. Substrate : 4 uM Tyr peptide 1
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 3 fibronectin type-III domains.Contains 1 protein kinase domain.
Tag : Non
Protein length : 999-1362
Gene Name : INSR insulin receptor [ Homo sapiens ]
Official Symbol : INSR
Synonyms : INSR; insulin receptor; CD220;
Gene ID : 3643
mRNA Refseq : NM_000208
Protein Refseq : NP_000199
MIM : 147670
Uniprot ID : P06213
Chromosome Location : 19p13.3-p13.2
Pathway : Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; IRS activation, organism-specific biosystem;
Function : 3-phosphoinositide-dependent protein kinase binding; ATP binding; GTP binding; PTB domain binding; SH2 domain binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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02/25/2020

    The compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.

    04/26/2016

      The product's support in the form of educational resources positively impacted the learning curve for our researchers.

      04/18/2016

        The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

        Q&As (7)

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        What impact does malfunction or dysregulation of the insulin receptor (INSR) have on metabolic health? 10/31/2020

        Malfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.

        How does the insulin receptor (INSR) function in regulating glucose metabolism in cells? 04/08/2020

        INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.

        What are the key tissues or cell types where the insulin receptor (INSR) is prominently expressed? 08/29/2019

        The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.

        Are there known genetic variations or mutations in the insulin receptor (INSR) associated with metabolic disorders or insulin resistance? 02/27/2019

        Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.

        In the context of diabetes, what role does the insulin receptor (INSR) play in the development of insulin resistance? 06/16/2018

        In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.

        What is the primary role of the insulin receptor (INSR) protein in cellular processes? 04/29/2017

        The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.

        How does the insulin receptor (INSR) activate downstream signaling pathways in response to insulin binding? 09/14/2016

        Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.

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