Active Recombinant Human INSR Protein, GST-tagged

• Cat.No.: INSR-5093H
• Product Overview: Human INSR (NM_000208, 989 a.a. - 1382 a.a.) partial recombinant protein with GST tag expressed in Sf9 cells.

Specification

• Description: After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Bio-activity: 533 pmol/μg x min
• Molecular Mass: 70.392 kDa
• Applications: Functional Study
  SDS-PAGE
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Concentration: 0.189 μg/μL
• Storage Buffer: In 50 mM Hepes, 100 mM NaCl, pH 7.5. (5 mM DTT, 4 mM reduced glutathione, 20% glycerol)
• Protein length: 989-1382

Gene Information

• Gene Name: INSR insulin receptor [ Homo sapiens ]
• Official Symbol: INSR
• Synonyms: INSR; insulin receptor; CD220; IR; HHF5
• Gene ID: 3643
• mRNA Refseq: NM_000208
• Protein Refseq: NP_000199
• MIM: 147670
• UniProt ID: P06213

Reviews

02/25/2020

The compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.

04/26/2016

The product's support in the form of educational resources positively impacted the learning curve for our researchers.

04/18/2016

The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

Q&As

What impact does malfunction or dysregulation of the insulin receptor (INSR) have on metabolic health?

Malfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.

How does the insulin receptor (INSR) function in regulating glucose metabolism in cells?

INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.

What are the key tissues or cell types where the insulin receptor (INSR) is prominently expressed?

The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.

Are there known genetic variations or mutations in the insulin receptor (INSR) associated with metabolic disorders or insulin resistance?

Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.

In the context of diabetes, what role does the insulin receptor (INSR) play in the development of insulin resistance?

In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.

What is the primary role of the insulin receptor (INSR) protein in cellular processes?

The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.

How does the insulin receptor (INSR) activate downstream signaling pathways in response to insulin binding?

Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.