Recombinant Human INSR protein, His-tagged
Cat.No. : | INSR-7894H |
Product Overview : | Recombinant Human INSR aa. (Pro622~Thr945 (Accession # P06213)) fused with N-terminal His tag was produced in E. coli cells. |
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Description : | This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 38.0kDa |
Protein length : | Pro622~Thr945 (Accession # P06213) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >90% |
Characteristic : | The isoelectric point is 6.5. |
Applications : | SDS-PAGE; WB; ELISA; IP |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | INSR insulin receptor [ Homo sapiens (human) ] |
Official Symbol : | INSR |
Synonyms : | HHF5; CD220; insulin receptor; IR |
Gene ID : | 3643 |
mRNA Refseq : | NM_000208.3 |
Protein Refseq : | NP_000199.2 |
UniProt ID : | P06213 |
Products Types
◆ Recombinant Protein | ||
INSR-1260H | Recombinant Human INSR Protein, His-SUMO-tagged | +Inquiry |
INSR-5093H | Active Recombinant Human INSR Protein, GST-tagged | +Inquiry |
INSR-1605C | Recombinant Crab-eating Macaque INSR Protein, Fc-tagged | +Inquiry |
INSR-4564M | Recombinant Mouse INSR Protein, His (Fc)-Avi-tagged | +Inquiry |
INSR-0997H | Recombinant Human INSR Protein (M1-S1382), eGFP, Strep II, 10×His tagged | +Inquiry |
◆ Lysates | ||
INSR-474HCL | Recombinant Human INSR cell lysate | +Inquiry |
INSR-2648HCL | Recombinant Human INSR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1605 | U2OS INSR Bioassay Kit | +Inquiry |
Kit-1607 | INSR Internalization Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.
The product's support in the form of educational resources positively impacted the learning curve for our researchers.
The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.
Q&As (7)
Ask a questionMalfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.
INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.
The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.
Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.
In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.
The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.
Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.
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