Recombinant Human INSR protein, His-tagged

Cat.No. : INSR-7894H
Product Overview : Recombinant Human INSR aa. (Pro622~Thr945 (Accession # P06213)) fused with N-terminal His tag was produced in E. coli cells.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 38.0kDa
Protein length : Pro622~Thr945 (Accession # P06213)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >90%
Characteristic : The isoelectric point is 6.5.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : INSR insulin receptor [ Homo sapiens (human) ]
Official Symbol : INSR
Synonyms : HHF5; CD220; insulin receptor; IR
Gene ID : 3643
mRNA Refseq : NM_000208.3
Protein Refseq : NP_000199.2
UniProt ID : P06213

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
02/25/2020

    The compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.

    04/26/2016

      The product's support in the form of educational resources positively impacted the learning curve for our researchers.

      04/18/2016

        The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

        Q&As (7)

        Ask a question
        What impact does malfunction or dysregulation of the insulin receptor (INSR) have on metabolic health? 10/31/2020

        Malfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.

        How does the insulin receptor (INSR) function in regulating glucose metabolism in cells? 04/08/2020

        INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.

        What are the key tissues or cell types where the insulin receptor (INSR) is prominently expressed? 08/29/2019

        The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.

        Are there known genetic variations or mutations in the insulin receptor (INSR) associated with metabolic disorders or insulin resistance? 02/27/2019

        Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.

        In the context of diabetes, what role does the insulin receptor (INSR) play in the development of insulin resistance? 06/16/2018

        In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.

        What is the primary role of the insulin receptor (INSR) protein in cellular processes? 04/29/2017

        The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.

        How does the insulin receptor (INSR) activate downstream signaling pathways in response to insulin binding? 09/14/2016

        Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.

        Ask a Question for All INSR Products

        Required fields are marked with *

        My Review for All INSR Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends