Recombinant Human Insulin Receptor, GST-tagged, Active

Cat.No. : INSR-331H
Product Overview : Recombinant human InsR (1011-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 70 kDa.
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Cat. No. : INSR-331H
Description : InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, α and β that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake. Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas β cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult β cells and the central control of nutrient homeostasis.
Source : Sf9 insect cells using baculovirus.
Sequence : 1011-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Protein length : 1011-end
Gene Name : INSR insulin receptor [ Homo sapiens ]
Synonyms : INSR; insulin receptor; HHF5; CD220; EC 2.7.10.1; IR; CD220 antigen; Insulin receptor subunit alpha; Insulin receptor subunit beta
Gene ID : 3643
mRNA Refseq : NM_000208
Protein Refseq : NP_000199
MIM : 147670
UniProt ID : P06213
Chromosome Location : 19p13.3-p13.2
Pathway : Adherens junction; Insulin signaling pathway; Type II diabetes mellitus
Function : 3-phosphoinositide-dependent protein kinase binding; ATP binding; GTP binding; PTB domain binding; SH2 domain binding; insulin binding; insulin receptor activity; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor II binding; insulin-like growth factor receptor binding; lipoic acid binding; manganese ion binding; metal ion binding; nucleotide binding; phosphoinositide 3-kinase binding; protein complex binding; protein phosphatase binding; receptor activity; receptor signaling protein tyrosine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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02/25/2020

    The compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.

    04/26/2016

      The product's support in the form of educational resources positively impacted the learning curve for our researchers.

      04/18/2016

        The proactive engagement with customer insights contributed to the product's ongoing relevance in the scientific community.

        Q&As (7)

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        What impact does malfunction or dysregulation of the insulin receptor (INSR) have on metabolic health? 10/31/2020

        Malfunction or dysregulation of the insulin receptor (INSR) can lead to disturbances in metabolic health, contributing to conditions like diabetes.

        How does the insulin receptor (INSR) function in regulating glucose metabolism in cells? 04/08/2020

        INSR regulates glucose metabolism by facilitating the cellular uptake of glucose in response to insulin.

        What are the key tissues or cell types where the insulin receptor (INSR) is prominently expressed? 08/29/2019

        The insulin receptor (INSR) is prominently expressed in tissues such as the liver, muscle, and adipose tissue.

        Are there known genetic variations or mutations in the insulin receptor (INSR) associated with metabolic disorders or insulin resistance? 02/27/2019

        Genetic variations or mutations in the insulin receptor (INSR) are associated with certain metabolic disorders and insulin resistance.

        In the context of diabetes, what role does the insulin receptor (INSR) play in the development of insulin resistance? 06/16/2018

        In diabetes, the insulin receptor (INSR) contributes to the development of insulin resistance, impairing its normal signaling functions.

        What is the primary role of the insulin receptor (INSR) protein in cellular processes? 04/29/2017

        The insulin receptor (INSR) protein plays a crucial role in cellular processes, particularly in mediating the effects of insulin.

        How does the insulin receptor (INSR) activate downstream signaling pathways in response to insulin binding? 09/14/2016

        Upon insulin binding, the insulin receptor (INSR) activates downstream signaling pathways, including the PI3K-AKT pathway.

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