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Recombinant Human S100A12 protein, Myc/DDK-tagged

Cat.No. : S100A12-33H
Product Overview : Recombinant protein of human S100 calcium binding protein A12 (S100A12) with a C-Myc/DDK tag was expressed in HEK293T.
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Description : The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.
Source : HEK293T
Species : Human
Tag : Myc&DDK
Molecular Mass : 10.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Gene Name : S100A12 S100 calcium binding protein A12 [ Homo sapiens (human) ]
Official Symbol : S100A12
Synonyms : S100A12; S100 calcium binding protein A12; p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE; protein S100-A12; EN-RAGE; calcitermin; calcium-binding protein in amniotic fluid 1; calgranulin C; extracellular newly identified RAGE-binding protein; migration inhibitory factor-related protein 6; neutrophil S100 protein
Gene ID : 6283
mRNA Refseq : NM_005621
Protein Refseq : NP_005612
MIM : 603112
UniProt ID : P80511

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
09/30/2022

    Precise protein quantification, fundamental for data accuracy in our experiments.

    03/11/2020

      Timely antibody validation, a valuable asset for our laboratory.

      02/26/2019

        Exceptional protein expression optimization support, greatly enhances our research.

        Q&As (7)

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        What are the mechanisms by which S100A12 modulates the expression of pro-inflammatory cytokines? 11/30/2022

        S100A12 regulates the production of pro-inflammatory cytokines, impacting the extent and severity of inflammation.

        What role does S100A12 play in the pathogenesis of inflammatory diseases like rheumatoid arthritis? 03/16/2022

        S100A12 is implicated in inflammatory diseases like rheumatoid arthritis, contributing to joint inflammation and damage.

        What is the impact of S100A12 on vascular inflammation and the development of atherosclerosis? 02/23/2022

        S100A12 contributes to vascular inflammation, potentially leading to the development of atherosclerosis.

        How does S100A12 contribute to the innate immune response, particularly in bacterial infections? 04/25/2021

        S100A12 plays a role in the innate immune response against bacterial infections, enhancing pathogen detection and response.

        How do alterations in S100A12 expression or function affect chronic inflammatory conditions and autoimmune diseases? 06/20/2020

        Changes in S100A12 expression can exacerbate chronic inflammatory and autoimmune diseases, affecting disease progression and symptoms.

        How does S100A12 influence calcium signaling and cellular activation in immune cells? 02/20/2020

        S100A12 influences calcium signaling in immune cells, affecting their activation and function.

        How does S100A12 (S100 Calcium Binding Protein A12) interact with receptors on immune cells to modulate inflammation? 01/10/2018

        S100A12 binds to receptors on immune cells, triggering inflammatory responses and modulating immune activity.

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