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Recombinant Human S100A12, His-tagged

Cat.No. : S100A12-3721H
Product Overview : Total 101 AA. MW: 11.63 kDa (calculated). N-Terminal His-tag, 10 extra AA (highlighted).
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Cat. No. : S100A12-3721H
Description : Protein S100-A12 is a protein that in humans is encoded by the S100A12 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.
Source : E. coli
Species : Human
Form : Filtered (0,4 μm) and lyophilized in 0.5 mg/mL in 20mM TRIS, 50mM NaCl, pH 7.5.
Reconstitution : Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Applications : Western blotting
Quality Control Test : BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein
Sequences of amino acids : MKHHHHHHAS TKLEEHLEGI VNIFHQYSVR KGHFDTLSKG ELKQLLTKEL ANTIKNIKDK AVIDEIFQGL DANQDEQVDF QEFISLVAIA LKAAHYHTHK E
Storage : Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.
Pathways : Activated TLR4 signalling; Advanced glycosylation endproduct receptor signaling; Innate Immunity Signaling; MyD88 cascade initiated on plasma membrane; MyD88 dependent cascade initiated on endosome; MyD88-independent cascade initiated on plasma membrane; NFkB and MAP kinases activation mediated by TLR4 signaling repertoire; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways; Signaling in Immune system; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 Mediated Induction of proinflammatory cytokines; TRAF6 mediated NF-kB activation; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; Toll Like Receptor 2 Cascade; Toll Like Receptor 3 (TLR3) Cascade
Gene Name : S100A12 S100 calcium binding protein A12 [ Homo sapiens ]
Official Symbol : S100A12
Synonyms : S100A12; S100 calcium binding protein A12; p6; CAGC; CGRP; MRP6; CAAF1; ENRAGE; protein S100-A12; EN-RAGE; calgranulin C; calgranulin-C; OTTHUMP00000015332; neutrophil S100 protein; calcium-binding protein in amniotic fluid 1; S100 calcium-binding protein A12 (calgranulin C); extracellular newly identified RAGE-binding protein; S100 calcium binding protein A12 (calgranulin C); Protein S100-A12; Calcium-binding protein in amniotic fluid 1; Calgranulin-C; Extracellular newly identified RAGE-binding protein; Neutrophil S100 protein; S100 calcium-binding protein A12; Calcitermin
Gene ID : 6283
mRNA Refseq : NM_005621
Protein Refseq : NP_005612
MIM : 603112
UniProt ID : P80511
Chromosome Location : 1q21
Function : RAGE receptor binding; RAGE receptor binding; calcium ion binding; protein binding; zinc ion binding

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
09/30/2022

    Precise protein quantification, fundamental for data accuracy in our experiments.

    03/11/2020

      Timely antibody validation, a valuable asset for our laboratory.

      02/26/2019

        Exceptional protein expression optimization support, greatly enhances our research.

        Q&As (7)

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        What are the mechanisms by which S100A12 modulates the expression of pro-inflammatory cytokines? 11/30/2022

        S100A12 regulates the production of pro-inflammatory cytokines, impacting the extent and severity of inflammation.

        What role does S100A12 play in the pathogenesis of inflammatory diseases like rheumatoid arthritis? 03/16/2022

        S100A12 is implicated in inflammatory diseases like rheumatoid arthritis, contributing to joint inflammation and damage.

        What is the impact of S100A12 on vascular inflammation and the development of atherosclerosis? 02/23/2022

        S100A12 contributes to vascular inflammation, potentially leading to the development of atherosclerosis.

        How does S100A12 contribute to the innate immune response, particularly in bacterial infections? 04/25/2021

        S100A12 plays a role in the innate immune response against bacterial infections, enhancing pathogen detection and response.

        How do alterations in S100A12 expression or function affect chronic inflammatory conditions and autoimmune diseases? 06/20/2020

        Changes in S100A12 expression can exacerbate chronic inflammatory and autoimmune diseases, affecting disease progression and symptoms.

        How does S100A12 influence calcium signaling and cellular activation in immune cells? 02/20/2020

        S100A12 influences calcium signaling in immune cells, affecting their activation and function.

        How does S100A12 (S100 Calcium Binding Protein A12) interact with receptors on immune cells to modulate inflammation? 01/10/2018

        S100A12 binds to receptors on immune cells, triggering inflammatory responses and modulating immune activity.

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