Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025

Recombinant Human S100A12, His-tagged

Cat.No. : S100A12-30229TH
Product Overview : Recombinant full length Human S100A12 with an N terminal His tag; 101 amino acids with tag, predicted MWt: 11.6 kDa.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.
Protein length : 91 amino acids
Conjugation : HIS
Molecular Weight : 11.600kDa inclusive of tags
Source : E. coli
Tissue specificity : Monocytes and lymphocytes.
Form : Lyophilised:Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Filter the product by an appropriate sterile filter before using it in the cell culture.
Purity : by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50mM Sodium chloride, 20mM Tris, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MKHHHHHHAS TKLEEHLEGI VNIFHQYSVR KGHFDTLSKG ELKQLLTKEL ANTIKNIKDK AVIDEIFQGL DANQDEQVDFQEFISLVAIA LKAAHYHTHK E
Sequence Similarities : Belongs to the S-101 family.Contains 2 EF-hand domains.
Gene Name : S100A12 S100 calcium binding protein A12 [ Homo sapiens ]
Official Symbol : S100A12
Synonyms : S100A12; S100 calcium binding protein A12; S100 calcium binding protein A12 (calgranulin C) , S100 calcium binding protein A12 (calgranulin C); protein S100-A12; CAAF1; CAGC; CGRP; ENRAGE; MRP6; p6;
Gene ID : 6283
mRNA Refseq : NM_005621
Protein Refseq : NP_005612
MIM : 603112
Uniprot ID : P80511
Chromosome Location : 1q21
Pathway : Activated TLR4 signalling, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem;
Function : RAGE receptor binding; RAGE receptor binding; calcium ion binding; protein binding; zinc ion binding;

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
09/30/2022

    Precise protein quantification, fundamental for data accuracy in our experiments.

    03/11/2020

      Timely antibody validation, a valuable asset for our laboratory.

      02/26/2019

        Exceptional protein expression optimization support, greatly enhances our research.

        Q&As (7)

        Ask a question
        What are the mechanisms by which S100A12 modulates the expression of pro-inflammatory cytokines? 11/30/2022

        S100A12 regulates the production of pro-inflammatory cytokines, impacting the extent and severity of inflammation.

        What role does S100A12 play in the pathogenesis of inflammatory diseases like rheumatoid arthritis? 03/16/2022

        S100A12 is implicated in inflammatory diseases like rheumatoid arthritis, contributing to joint inflammation and damage.

        What is the impact of S100A12 on vascular inflammation and the development of atherosclerosis? 02/23/2022

        S100A12 contributes to vascular inflammation, potentially leading to the development of atherosclerosis.

        How does S100A12 contribute to the innate immune response, particularly in bacterial infections? 04/25/2021

        S100A12 plays a role in the innate immune response against bacterial infections, enhancing pathogen detection and response.

        How do alterations in S100A12 expression or function affect chronic inflammatory conditions and autoimmune diseases? 06/20/2020

        Changes in S100A12 expression can exacerbate chronic inflammatory and autoimmune diseases, affecting disease progression and symptoms.

        How does S100A12 influence calcium signaling and cellular activation in immune cells? 02/20/2020

        S100A12 influences calcium signaling in immune cells, affecting their activation and function.

        How does S100A12 (S100 Calcium Binding Protein A12) interact with receptors on immune cells to modulate inflammation? 01/10/2018

        S100A12 binds to receptors on immune cells, triggering inflammatory responses and modulating immune activity.

        Ask a Question for All S100A12 Products

        Required fields are marked with *

        My Review for All S100A12 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2025 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends