Recombinant Human S100A12, His-tagged
Cat.No. : | S100A12-30229TH |
Product Overview : | Recombinant full length Human S100A12 with an N terminal His tag; 101 amino acids with tag, predicted MWt: 11.6 kDa. |
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Description : | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. |
Protein length : | 91 amino acids |
Conjugation : | HIS |
Molecular Weight : | 11.600kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Monocytes and lymphocytes. |
Form : | Lyophilised:Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Filter the product by an appropriate sterile filter before using it in the cell culture. |
Purity : | by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50mM Sodium chloride, 20mM Tris, pH 7.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MKHHHHHHAS TKLEEHLEGI VNIFHQYSVR KGHFDTLSKG ELKQLLTKEL ANTIKNIKDK AVIDEIFQGL DANQDEQVDFQEFISLVAIA LKAAHYHTHK E |
Sequence Similarities : | Belongs to the S-101 family.Contains 2 EF-hand domains. |
Gene Name : | S100A12 S100 calcium binding protein A12 [ Homo sapiens ] |
Official Symbol : | S100A12 |
Synonyms : | S100A12; S100 calcium binding protein A12; S100 calcium binding protein A12 (calgranulin C) , S100 calcium binding protein A12 (calgranulin C); protein S100-A12; CAAF1; CAGC; CGRP; ENRAGE; MRP6; p6; |
Gene ID : | 6283 |
mRNA Refseq : | NM_005621 |
Protein Refseq : | NP_005612 |
MIM : | 603112 |
Uniprot ID : | P80511 |
Chromosome Location : | 1q21 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 cascade initiated on plasma membrane, organism-specific biosystem; |
Function : | RAGE receptor binding; RAGE receptor binding; calcium ion binding; protein binding; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
S100A12-2002H | Recombinant Human S100A12 Protein, His-tagged | +Inquiry |
S100A12-289H | Recombinant Human S100A12 Protein, His-tagged(C-ter) | +Inquiry |
S100A12-33H | Recombinant Human S100A12 protein, Myc/DDK-tagged | +Inquiry |
S100A12-1936H | Recombinant Human S100A12 Protein, His (Fc)-Avi-tagged | +Inquiry |
S100A12-3096H | Active Recombinant Human S100A12 protein(Met1-Glu92) | +Inquiry |
◆ Lysates | ||
S100A12-2094HCL | Recombinant Human S100A12 293 Cell Lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewPrecise protein quantification, fundamental for data accuracy in our experiments.
Timely antibody validation, a valuable asset for our laboratory.
Exceptional protein expression optimization support, greatly enhances our research.
Q&As (7)
Ask a questionS100A12 regulates the production of pro-inflammatory cytokines, impacting the extent and severity of inflammation.
S100A12 is implicated in inflammatory diseases like rheumatoid arthritis, contributing to joint inflammation and damage.
S100A12 contributes to vascular inflammation, potentially leading to the development of atherosclerosis.
S100A12 plays a role in the innate immune response against bacterial infections, enhancing pathogen detection and response.
Changes in S100A12 expression can exacerbate chronic inflammatory and autoimmune diseases, affecting disease progression and symptoms.
S100A12 influences calcium signaling in immune cells, affecting their activation and function.
S100A12 binds to receptors on immune cells, triggering inflammatory responses and modulating immune activity.
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