Recombinant Human SPAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : SPAM1-1187H
Product Overview : SPAM1 MS Standard C13 and N15-labeled recombinant protein (NP_003108) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 58.2 kDa
AA Sequence : MGVLKFKHIFFRSFVKSSGVSQIVF TFLLIPCCLTLNFRAPPVIPNVPFL WAWNAPSEFCLGKFDEPLDMSLFSF IGSPRINATGQGVTIFYVDRLGYYP YIDSITGVTVNGGIPQKISLQDHLD KAKKDITFYMPVDNLGMAVIDWEEW RPTWARNWKPKDVYKNRSIELVQQQ NVQLSLTEATEKAKQEFEKAGKDFL VETIKLGKLLRPNHLWGYYLFPDCY NHHYKKPGYNGSCFNVEIKRNDDLS WLWNESTALYPSIYLNTQQSPVAAT LYVRNRVREAIRVSKIPDAKSPLPV FAYTRIVFTDQVLKFLSQDELVYTF GETVALGASGIVIWGTLSIMRSMKS CLLLDNYMETILNPYIINVTLAAKM CSQVLCQEQGVCIRKNWNSSDYLHL NPDNFAIQLEKGGKFTVRGKPTLED LEQFSEKFYCSCYSTLSCKEKADVK DTDAVDVCIADGVCIDAFLKPPMET EEPQIFYNASPSTLSATMFIWRLEV WDQGISRIGFFTRTRPLEQKLISEE DLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE:
Gene Name : SPAM1 sperm adhesion molecule 1 [ Homo sapiens (human) ]
Official Symbol : SPAM1
Synonyms : SPAM1; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); hyaluronidase PH-20; HYAL5; PH 20; SPAG15; hyal-PH20; sperm surface protein PH-20; hyaluronoglucosaminidase PH-20; HYA1; PH20; HYAL1; HYAL3; PH-20; MGC26532;
Gene ID : 6677
mRNA Refseq : NM_003117
Protein Refseq : NP_003108
MIM : 600930
UniProt ID : P38567

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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