Recombinant Human Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding), His-Fc-Tagged
Cat.No. : | TNFSF11-313H |
Product Overview : | The monoclonal antibody to RANKL is a human IgG2 monoclonal antibody, have affinity and specificity with human RANKL (receptor activator of nuclear factor kappa-B ligand). 147 kDa Molecular weight, is genetically engineered mammalian (Chinese hamster ovary) cell production. |
- Specification
- Gene Information
- Related Products
- Download
Cat. No. : | TNFSF11-313H |
Description : | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
Source : | Human |
Host : | Chinese Hamster Ovary |
Form : | Sterilized PBS, pH7.4 |
Purity : | > 95%; |
Endotoxin : | <1.0EU/10mg(LAL gel) |
Stability : | 4μ: 6months. -20μ: 1 year, avoiding repeated freezing and thawing. |
Predicted N terminal : | H-strand: EVQLLESGGG; L-strand: EIVLTQSPGT |
Molecular Mass : | OPGL monoclonal antibody consists of 1326 Amino acids, Molecular Mass is 147KDa. |
Storage : | 4μ for 6 months; -20 μ for 1 year, Avoiding repeated freezing and thawing. |
Tag : | His&Fc |
Gene Name : | TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens ] |
Official Symbol : | TNFSF11 |
Synonyms : | TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; tumor necrosis factor ligand superfamily, member 11; OTTHUMP00000178585; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; CD254 antigen; Osteoprotegerin ligand |
Gene ID : | 8600 |
mRNA Refseq : | NM_003701 |
Protein Refseq : | NP_003692 |
MIM : | 602642 |
UniProt ID : | O14788 |
Chromosome Location : | 13q14 |
Pathway : | Cytokine-cytokine receptor interaction |
Function : | cytokine activity; protein binding; receptor activity; tumor necrosis factor receptor binding |
Products Types
◆ Recombinant Protein | ||
SPAM1-2080H | Recombinant Human SPAM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Spam1-2091R | Recombinant Rat Spam1 Protein, His-tagged | +Inquiry |
Spam1-2092M | Recombinant Mouse Spam1 Protein, His-tagged | +Inquiry |
SPAM1-805H | Recombinant Human SPAM1 Protein | +Inquiry |
SPAM1-15H | Recombinant Human SPAM1 Protein, C-Myc/DDK-tagged | +Inquiry |
◆ Native Protein | ||
Hyaluronidase-35O | Active Native Ovine Hyaluronidase, 300U/mg | +Inquiry |
◆ Lysates | ||
SPAM1-1546HCL | Recombinant Human SPAM1 293 Cell Lysate | +Inquiry |
Related Gene
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All SPAM1 Products
Required fields are marked with *
My Review for All SPAM1 Products
Required fields are marked with *
0
Inquiry Basket