SPHK1
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Official Full Name
sphingosine kinase 1
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Overview
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] -
Synonyms
SPHK1; sphingosine kinase 1; SPHK; SK 1; SPK 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect cell
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21 Insect Cell
- Sf9 Insect Cell
- Fc
- Flag
- GST
- His
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
SPHK1 involved in several pathways and played different roles in them. We selected most pathways SPHK1 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPHK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Sphingolipid metabolism | B4GALT6;GALCA;SMPD4;GLTPD1;SGMS1;UGCG;ARSE;SERINC1;LASS1 |
Metabolic pathways | TYRP1;EPHX2;PIGF;DNMT3AA;CERS4;NDST3;SDHD;MOCS1;PTGDS |
Calcium signaling pathway | AGTR1;EDNRB2;CHRM5;RYR3;ADRB3A;SLC8A3;ATP2A2B;ITPKB;CYSLTR1 |
Sphingolipid signaling pathway | ASAH2;HRAS;PIK3CD;PPP2R5A;ROCK1;PIK3CA;PIK3CG;RAF1;TRAF2 |
Phospholipase D signaling pathway | PIK3CD;SOS1;INSR;LPAR3;F2R;PLD2;RHEB;CYTH1;PDGFB |
VEGF signaling pathway | PTK2AA;PLA2G4A;NFATC2;VEGFAB;RAC3A;MAPK12B;CDC42L;MAPK3;PIK3CD |
Fc gamma R-mediated phagocytosis | CFL1;FCGR2A;FCGR1A;RPS6KB1;RPS6KB2;WASF2;FCGR2B;SCIN;NCF1 |
Tuberculosis | ARHGEF12;CAMK2D;AKT2;IL10RA;IFNGR1;PPP3CC;PPP3CB;LAMP1;NFKB1 |
SPHK1 has several biochemical functions, for example, ATP binding, D-erythro-sphingosine kinase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPHK1 itself. We selected most functions SPHK1 had, and list some proteins which have the same functions with SPHK1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | CHD6;SGK196;KIF15;ATP4A;PGS1;LATS1;KIF17;ILF2;NADSYN1 |
D-erythro-sphingosine kinase activity | SPHK2;SPHK1 |
DNA binding | ATM;DICER1;LIG3;ASXL1;ALX4;H2AFX;NKX2.3;ZNF574;RXRA |
calmodulin binding | VAMP2;SLC14A2;EWSR1;CAMK2D;MAPKAPK2;GEM;MYO10;PLCB1;CALD1 |
magnesium ion binding | DCTPP1;FAN1;PKMB;LHPP;RPS6KA3A;IRAK4;INPP1;PTENB;NME1 |
protein binding | TSGA10IP;PRMT3;LAX1;PDE2A;MRC2;CTLA4;COPS7A;STEAP3;PRKAB2 |
protein phosphatase 2A binding | TP53;MAPT;BCL2;FOXO1;ENSA;SHC1;AKT1;HMGCR;EIF4EBP1 |
sphinganine kinase activity | SPHK1;SPHK2 |
sphingosine-1-phosphate receptor activity | GPR6;S1PR5A;S1PR4;S1PR3A;S1PR1;S1PR3;S1PR2;S1PR5B;S1PR5 |
SPHK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPHK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPHK1.
SPHKAP; EEF1A1; FHL2; FYN; CTSB; TRAF6
Research Area
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Customer Reviews (3)
Write a reviewIts seamless integration makes it possible to explore different research avenues, expanding the scope and impact of my investigations.
With the manufacturer's excellent technical support and its wide range of applications, the SPHK1 protein has become an indispensable tool, aiding in my research endeavors and driving meaningful scientific discoveries.
Their team of experts is readily available to address any issues that may arise, providing solutions to problems and guiding me through the experimental process.
Q&As (5)
Ask a questionElevated SPHK1 levels have been associated with drug resistance in cancer cells, making it a potential target to overcome resistance mechanisms.
SPHK1 regulates immune cell trafficking and function by modulating S1P levels. This is significant in autoimmune diseases and inflammatory responses.
Understanding the role of SPHK1 in different diseases may contribute to the development of personalized therapeutic approaches, tailoring treatments based on individual patient characteristics and disease profiles.
SPHK1 is involved in endothelial cell functions and angiogenesis, making it a potential target in the treatment of vascular diseases.
Yes, combining SPHK1 inhibitors with other therapeutic agents is being explored to enhance treatment efficacy, especially in cancer.
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