SPHK1

  • Official Full Name

    sphingosine kinase 1

  • Overview

    The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
  • Synonyms

    SPHK1; sphingosine kinase 1; SPHK; SK 1; SPK 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • DDK
  • Fc
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Met|His
  • Myc
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPHK1-741H Active Recombinant Human SPHK1 Protein, Met & His-tagged Sf21 Insect Cell Met/His Asp2-Leu398
Human SPHK1-1483H Active Recombinant Human SPHK1, GST-tagged Sf9 Insect Cell GST Full length
Human SPHK1-174H Active Recombinant Human SPHK1 protein, GST-tagged Insect Cell GST
Human SPHK1-1331H Acitve Recombinant Human SPHK1 protein(Met1-Leu384) Insect Cells N/A Met1-Leu384
Human SPHK1-656H Recombinant Human SPHK1 Mammalian Cell His
Human SPHK1-263H Recombinant Human SPHK1, Gly & Pro tagged Insect Cell Fc
Human SPHK1-2915H Recombinant Human SPHK1, GST-tagged E.coli GST 37-384aa
Human SPHK1-523H Recombinant Human Sphingosine Kinase 1, His-tagged Sf9 Insect Cell His
Human SPHK1-1299H Recombinant Human SPHK1 protein, His-tagged E.coli His Leu148~Leu398 (Accession # Q9NYA1)
Human SPHK1-277H Recombinant Human SPHK1, His-GST tagged Insect Cell N/A
Human SPHK1-77H Recombinant Human SPHK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human SPHK1-001HCL Recombinant Human SPHK1 cell lysate Insect Cell N/A
Human SPHK1-2567H Recombinant Human SPHK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SPHK1-0269H Recombinant Human SPHK1 Protein (M1-S363), Tag Free Insect Cell No tag M1-S363
Human SPHK1-012H Recombinant Human SPHK1 Protein, His-tagged Insect Cells His
Human SPHK1-0268H Recombinant Human SPHK1 Protein (M1-S363), His tagged Insect Cell His M1-S363
Human SPHK1-091H Recombinant Human SPHK1 Protein, His-tagged Insect cell His
Human SPHK1-4199H Recombinant Human SPHK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SPHK1-6385HF Active Recombinant Full Length Human SPHK1 Protein, GST-tagged Insect (sf21) GST 1-384(end)
Human SPHK1-4130H-B Recombinant Human SPHK1 Protein Pre-coupled Magnetic Beads HEK293
Human SPHK1-12H Recombinant Human SPHK1 Protein, N-His-tagged Sf9 Insect Cell N-His
Human SPHK1-1441HF Active Recombinant Full Length Human SPHK1 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-384(end)
Human SPHK1-4130H Recombinant Human SPHK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SPHK1-0259H Recombinant Human SPHK1 protein, His&GST-tagged Insect Cells His/GST Met1-Leu384
Human SPHK1-6675H Recombinant Human SPHK1 Protein (Ser148-Leu398), His tagged E.coli His Ser148-Leu398
Mouse Sphk1-526M Active Recombinant Mouse Sphk1 protein, Met/His-tagged Insect Cell Met/His
Mouse Sphk1-524M Recombinant Mouse Sphingosine Kinase 1, His-tagged Sf9 Insect Cell His
Mouse SPHK1-15877M Recombinant Mouse SPHK1 Protein Mammalian Cell His
Mouse SPHK1-8642M-B Recombinant Mouse SPHK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Sphk1-6092M Recombinant Mouse Sphk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SPHK1-8642M Recombinant Mouse SPHK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SPHK1-5705R Recombinant Rat SPHK1 Protein Mammalian Cell His
Rat SPHK1-5364R Recombinant Rat SPHK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SPHK1-5364R-B Recombinant Rat SPHK1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SPHK1 involved in several pathways and played different roles in them. We selected most pathways SPHK1 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPHK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid metabolismPPAP2D;GDF1;PPM1LA;SPTLC2A;SMPD2;CERS4;ARSD;ASAH1;SPHK1
Metabolic pathwaysALAS2;DGAT1;HMGCL;CYP2A4;ATP6V1C2;Aldh1a7;AK8;TYRP1B;FUK
Calcium signaling pathwayPPIFA;CHRNA7;CALM1;ATP2A2;TACR1A;GNAS;PPIFB;PLCD1B;CALM2
Sphingolipid signaling pathwayTNF;ROCK2;NOS3;MAPK13;PLCB4;TRP53;PLCB3;PRKCZ;SPHK1
Phospholipase D signaling pathwayTSC2;FCER1G;CXCR1;MAPK3;PLA2G4F;PIK3R3;PLCB3;GRM3;MS4A2
VEGF signaling pathwayPRKCBB;PTK2AA;PPP3CB;PPP3CC;PLA2G4A;MAP2K2;RAC1B;RAF1B;PRKCG
Fc gamma R-mediated phagocytosisMAP2K1;DOCK2;FCGR2B;WASF3;CFL1;VAV2;PIK3CB;AKT2;PLA2G4A
TuberculosisCasp3;IRAK1;HSPD1;CASP8;MAPK8;CORO1A;BCL2;FCGR3;CD209C

SPHK1 has several biochemical functions, for example, ATP binding, D-erythro-sphingosine kinase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPHK1 itself. We selected most functions SPHK1 had, and list some proteins which have the same functions with SPHK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingACLY;SUCLA2;MYH7B;OBSCN;HELQ;NUBPL;ABCG4B;ATP6V1B2;RIPK1L
D-erythro-sphingosine kinase activitySPHK1;SPHK2
DNA bindingASH2L;ZNF599;HMBOX1A;JRK;ZFP821;HIST1H2A9;HER12;HDGF;SIX4
calmodulin bindingPLCB1;MYH1B;SLC14A2;MYH9;MYH11;NOS2;MAP6D1;PATE4;MYH10
magnesium ion bindingMAPK12;PKM;WEE2;PAPOLA;NT5C1B;ATP11A;COMTA;IRAK4;ERN1
protein bindingCHRNA5;MAP3K9;TRPS1;KCNJ5;MAFG;ACD;THBS1;TRIM11;HACE1
protein phosphatase 2A bindingCPD;AKT1;PPP2R2A;STRN;FOXO1;CTTNBP2NL;BCL2;STRN4;ENSA
sphinganine kinase activitySPHK2;SPHK1
sphingosine-1-phosphate receptor activityS1PR2;S1PR4;S1PR3A;SPHK1;S1PR5A;S1PR1;S1PR3;SPHK2;GPR6

SPHK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPHK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPHK1.

SPHKAP; EEF1A1; FHL2; FYN; CTSB; TRAF6

Research Area

Related articles

Eberlein, C; Rooney, C; et al. E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin alpha v beta 6 and maintained through TGF beta signalling. ONCOGENE 34:704-716(2015).
Camare, C; Trayssac, M; et al. Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. BRITISH JOURNAL OF PHARMACOLOGY 172:106-118(2015).
  • Q&As
  • Reviews

Q&As (5)

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How does SPHK1 contribute to drug resistance in cancer? 10/09/2021

Elevated SPHK1 levels have been associated with drug resistance in cancer cells, making it a potential target to overcome resistance mechanisms.

How does SPHK1 contribute to immune regulation? 08/03/2021

SPHK1 regulates immune cell trafficking and function by modulating S1P levels. This is significant in autoimmune diseases and inflammatory responses.

How might the modulation of SPHK1 impact personalized medicine? 04/06/2018

Understanding the role of SPHK1 in different diseases may contribute to the development of personalized therapeutic approaches, tailoring treatments based on individual patient characteristics and disease profiles.

How does SPHK1 influence vascular functions? 01/11/2017

SPHK1 is involved in endothelial cell functions and angiogenesis, making it a potential target in the treatment of vascular diseases.

Can SPHK1 inhibitors be used in combination therapies? 04/24/2016

Yes, combining SPHK1 inhibitors with other therapeutic agents is being explored to enhance treatment efficacy, especially in cancer.

Customer Reviews (3)

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Reviews
04/16/2023

    Its seamless integration makes it possible to explore different research avenues, expanding the scope and impact of my investigations.

    04/14/2020

      With the manufacturer's excellent technical support and its wide range of applications, the SPHK1 protein has become an indispensable tool, aiding in my research endeavors and driving meaningful scientific discoveries.

      01/03/2020

        Their team of experts is readily available to address any issues that may arise, providing solutions to problems and guiding me through the experimental process.

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