Recombinant Human SPHK1 protein, His&GST-tagged

Cat.No. : SPHK1-0259H
Product Overview : Recombinant Human SPHK1 protein(Q9NYA1-1)(Met1-Leu384), fused with His and GST tag, was expressed in Insect Cells.
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Source : Insect Cells
Species : Human
Tag : His&GST
Form : Supplied as sterile 20mM Tris, 500mM NaCl, 3mM DTT, 10% glycerol, pH 8.0.Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hard copy of CoA.
Molecular Mass : The secreted recombinant human SPHK1 consists of 621 amino acids and predicts a molecular mass of 70.3 KDa. The apparent molecular mass of the protein is approximately 64 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Proteinlength : Met1-Leu384
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : SPHK1 sphingosine kinase 1 [ Homo sapiens ]
Official Symbol : SPHK1
Synonyms : SPHK1; sphingosine kinase 1; SPHK; SK 1; SPK 1;
Gene ID : 8877
mRNA Refseq : NM_001142601
Protein Refseq : NP_001136073
MIM : 603730
UniProt ID : Q9NYA1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does SPHK1 contribute to drug resistance in cancer? 10/09/2021

Elevated SPHK1 levels have been associated with drug resistance in cancer cells, making it a potential target to overcome resistance mechanisms.

How does SPHK1 contribute to immune regulation? 08/03/2021

SPHK1 regulates immune cell trafficking and function by modulating S1P levels. This is significant in autoimmune diseases and inflammatory responses.

How might the modulation of SPHK1 impact personalized medicine? 04/06/2018

Understanding the role of SPHK1 in different diseases may contribute to the development of personalized therapeutic approaches, tailoring treatments based on individual patient characteristics and disease profiles.

How does SPHK1 influence vascular functions? 01/11/2017

SPHK1 is involved in endothelial cell functions and angiogenesis, making it a potential target in the treatment of vascular diseases.

Can SPHK1 inhibitors be used in combination therapies? 04/24/2016

Yes, combining SPHK1 inhibitors with other therapeutic agents is being explored to enhance treatment efficacy, especially in cancer.

Customer Reviews (3)

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Reviews
04/16/2023

    Its seamless integration makes it possible to explore different research avenues, expanding the scope and impact of my investigations.

    04/14/2020

      With the manufacturer's excellent technical support and its wide range of applications, the SPHK1 protein has become an indispensable tool, aiding in my research endeavors and driving meaningful scientific discoveries.

      01/03/2020

        Their team of experts is readily available to address any issues that may arise, providing solutions to problems and guiding me through the experimental process.

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