Recombinant Human SPHK1 Protein, His-tagged

Cat.No. : SPHK1-012H
Product Overview : Recombinant Human SPHK1 protein with a N-terminal His-tag was expressed in Insect Cell
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Description : The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : Insect Cells
Species : Human
Tag : His
Molecular Mass : 47.5 kDa
Purity : ≥80% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to produce 1 µmol of ADP per minute at 25 centigrade in 20 mM HEPES, pH 7.4, containing 50 mM sodium chloride, 10 mM magnesium chloride, 1 mM EGTA, and 0.02% Triton X-100.
Stability : ≥ 1 year
Storage : -80 centigrade
Storage Buffer : 25 mM HEPES, pH 8.0, with 150 mM sodium chloride, 3 mM DTT, 0.05% polysorbate 20, and 25% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
SDS-PAGE:
Gene Name : SPHK1 sphingosine kinase 1 [ Homo sapiens (human) ]
Official Symbol : SPHK1
Synonyms : SPHK1; sphingosine kinase 1; SPHK; phingosine kinase 1; SK 1; SPK 1; acetyltransferase SPHK1; EC 2.7.1.91
Gene ID : 8877
mRNA Refseq : NM_001142601
Protein Refseq : NP_001136073
MIM : 603730
UniProt ID : Q9NYA1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does SPHK1 contribute to drug resistance in cancer? 10/09/2021

Elevated SPHK1 levels have been associated with drug resistance in cancer cells, making it a potential target to overcome resistance mechanisms.

How does SPHK1 contribute to immune regulation? 08/03/2021

SPHK1 regulates immune cell trafficking and function by modulating S1P levels. This is significant in autoimmune diseases and inflammatory responses.

How might the modulation of SPHK1 impact personalized medicine? 04/06/2018

Understanding the role of SPHK1 in different diseases may contribute to the development of personalized therapeutic approaches, tailoring treatments based on individual patient characteristics and disease profiles.

How does SPHK1 influence vascular functions? 01/11/2017

SPHK1 is involved in endothelial cell functions and angiogenesis, making it a potential target in the treatment of vascular diseases.

Can SPHK1 inhibitors be used in combination therapies? 04/24/2016

Yes, combining SPHK1 inhibitors with other therapeutic agents is being explored to enhance treatment efficacy, especially in cancer.

Customer Reviews (3)

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04/16/2023

    Its seamless integration makes it possible to explore different research avenues, expanding the scope and impact of my investigations.

    04/14/2020

      With the manufacturer's excellent technical support and its wide range of applications, the SPHK1 protein has become an indispensable tool, aiding in my research endeavors and driving meaningful scientific discoveries.

      01/03/2020

        Their team of experts is readily available to address any issues that may arise, providing solutions to problems and guiding me through the experimental process.

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