Active Recombinant Mouse Sphk1 protein, Met/His-tagged

Cat.No. : Sphk1-526M
Product Overview : Recombinant Mouse Sphk1(Glu2-Pro382) fused with an N-terminal Met and 6-His tag was expressed in Insect cells.
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Source : Insect cells
Species : Mouse
Tag : His
Form : Supplied as a 0.2 μm filtered solution in MES, NaCl, Glycerol and DTT.
Bio-activity : Measured by its ability to phosphorylate Omega-(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-sphingosine (NBD-sphingosine). The specific activity is >2,500 pmol/min/μg.
Molecular Mass : Predicted Molecular Mass: 43 kDa;SDS-PAGE: 42 kDa, reducing conditions;
Endotoxin : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane
Storage : Avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 centigrade as supplied.3 months, -70 centigrade under sterile conditions after opening.
Gene Name : Sphk1 sphingosine kinase 1 [ Mus musculus ]
Official Symbol : Sphk1
Synonyms : SPHK1; sphingosine kinase 1; SK 1; SPK 1; Sk1; Spk1; 1110006G24Rik;
Gene ID : 20698
mRNA Refseq : NM_001172472
Protein Refseq : NP_001165943
UniProt ID : Q8CI15
Chromosome Location : 11; 11 E2
Pathway : Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Chaperonin-mediated protein folding, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function : ATP binding; D-erythro-sphingosine kinase activity; DNA binding; calmodulin binding; calmodulin binding; diacylglycerol kinase activity; kinase activity; magnesium ion binding; nucleotide binding; protein phosphatase 2A binding; sphinganine kinase activity; sphinganine kinase activity; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does SPHK1 contribute to drug resistance in cancer? 10/09/2021

Elevated SPHK1 levels have been associated with drug resistance in cancer cells, making it a potential target to overcome resistance mechanisms.

How does SPHK1 contribute to immune regulation? 08/03/2021

SPHK1 regulates immune cell trafficking and function by modulating S1P levels. This is significant in autoimmune diseases and inflammatory responses.

How might the modulation of SPHK1 impact personalized medicine? 04/06/2018

Understanding the role of SPHK1 in different diseases may contribute to the development of personalized therapeutic approaches, tailoring treatments based on individual patient characteristics and disease profiles.

How does SPHK1 influence vascular functions? 01/11/2017

SPHK1 is involved in endothelial cell functions and angiogenesis, making it a potential target in the treatment of vascular diseases.

Can SPHK1 inhibitors be used in combination therapies? 04/24/2016

Yes, combining SPHK1 inhibitors with other therapeutic agents is being explored to enhance treatment efficacy, especially in cancer.

Customer Reviews (3)

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Reviews
04/16/2023

    Its seamless integration makes it possible to explore different research avenues, expanding the scope and impact of my investigations.

    04/14/2020

      With the manufacturer's excellent technical support and its wide range of applications, the SPHK1 protein has become an indispensable tool, aiding in my research endeavors and driving meaningful scientific discoveries.

      01/03/2020

        Their team of experts is readily available to address any issues that may arise, providing solutions to problems and guiding me through the experimental process.

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