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Recombinant Rat Timp1 protein, His-tagged

Cat.No. : Timp1-2790R
Product Overview : Recombinant Rat Timp1 aa. (Cys24~Ala217 (Accession # P30120)) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Source : E. coli
Species : Rat
Tag : His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 23.1kDa
Protein length : Cys24~Ala217 (Accession # P30120)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 8.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Timp1 TIMP metallopeptidase inhibitor 1 [ Rattus norvegicus (Norway rat) ]
Official Symbol : Timp1
Synonyms : Timp; TIMP-1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1; metalloproteinase inhibitor 1
Gene ID : 116510
mRNA Refseq : NM_053819.1
Protein Refseq : NP_446271.1
UniProt ID : P30120

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the molecular consequences of dysregulated TIMP1 expression in cancer progression? 01/06/2022

Dysregulated TIMP1 expression in cancer can disrupt the balance between MMPs and TIMPs, contributing to excessive extracellular matrix degradation, invasion, and metastasis.

Can you explain the molecular role of TIMP1 in the inhibition of metalloproteinases? 06/30/2020

TIMP1 inhibits metalloproteinases by forming a complex with them, blocking their active sites and preventing the degradation of extracellular matrix components.

How does the nuclear localization of FXN contribute to its role in cellular processes? 03/02/2020

FXN's nuclear localization is associated with its involvement in DNA repair processes, influencing genomic stability and contributing to the overall cellular response to stress.

Can you explain the interplay between TIMP1 and the immune system in inflammatory processes? 07/13/2019

TIMP1 has immunomodulatory effects, influencing inflammation by regulating immune cell migration, cytokine production, and interactions with the extracellular matrix.

What is the significance of TIMP1 in tissue homeostasis and repair? 10/19/2018

TIMP1 plays a crucial role in tissue homeostasis and repair by controlling the activity of MMPs, which are involved in remodeling the extracellular matrix during physiological and pathological processes.

Customer Reviews (3)

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Reviews
04/16/2021

    The efficient delivery of this product ensured that our research timelines were met without any complications.

    08/03/2020

      Impressed by the professionalism of the customer service team—responsive and knowledgeable about the entire product range.

      12/08/2018

        This recombined protein has become a go-to in our lab due to its reliability and the precision it brings to our experiments.

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