WD-repeat protein 5

• Cat.No.: CBCRY09

Specification

• Cat. No.: CBCRY09
• Background: The WD40 repeat protein WDR5 specifically associates with the K4-methylated histone H3 in human cells. The structure of WDR5 in complex with a dimethylated H3-K4 peptide was deterimined. Unlike the chromodomain that recognizes the methylated H3-K4 through a hydrophobic cage, the specificity of WDR5 for methylated H3-K4 is conferred by the nonconventional hydrogen bonds between the two zeta-methyl groups of the dimethylated Lys4 and the carboxylate oxygen of Glu322 in WDR5. The three amino acids Ala-Arg-Thr preceding Lys4 form most of the specific contacts with WDR5, with Ala1 forming intermolecular hydrogen bonds and salt bridges, and the side chain of Arg2 inserting into the central channel of WDR5.
• Protein Classification: Structural protein and DNA binding protein
• Structure Weight: 35306.44 Da
• Polymer: 1
• Molecule: WD-repeat protein 5
• Chain Length: 311 amino acids
• PDB ID: 2G9A
• MMDB ID: 41532
• Source: E.coli
• Method: X-Ray Diffraction
• Resolution: 2.7 Å
• Reference: Han Z, Guo L, Wang H, Shen Y, Deng XW, Chai J. Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Mol. Cell 2006, 22(1):137-44.
• Tag: Non

Gene Information

• Gene Name: WDR5
• Synonyms: BIG-3; BIG3; BMP2-induced 3-kb gene protein; SWD3, Set1c WD40 repeat protein, homolog; WD-repeat protein 5; WD repeat domain 5
• UniProt ID: P61964
• Gene ID: 11091
• Chromosome Location: 9q34
• Function: protein binding

Reviews

11/25/2020

Their ability to accommodate the requirements of large-scale experiments and guarantee a reliable supply streamlines my research operations, eliminating any concerns related to potential shortages.

10/10/2020

I am confident that the protein will reliably perform in my assays, providing accurate and reproducible results.

09/25/2017

the manufacturer's supply management capabilities assure a seamless and continuous provision of the WDR5 protein.

Q&As

Can WDR5 play a role in non-cancerous diseases?

Yes, WDR5 has been associated with neurodevelopmental disorders, suggesting a role in non-cancerous diseases as well.

How does WDR5 affect neurodevelopment?

WDR5 regulates the expression of genes critical for neural development, and dysregulation can lead to developmental disorders.

How can WDR5 be used as a diagnostic marker for cancer?

Elevated levels of WDR5 in certain cancers can serve as a diagnostic marker when detected in patient samples.

Are there any clinical trials involving WDR5-targeted therapies?

Yes, there are ongoing clinical trials to test the safety and efficacy of WDR5-targeted therapies in cancer patients.

Is there a connection between WDR5 and autoimmune diseases?

Some studies suggest a potential link between WDR5 and autoimmune diseases, but further research is needed to confirm this association.