Recombinant Human WDR5 protein, His-SUMO-tagged

• Cat.No.: WDR5-3760H
• Product Overview: Recombinant Human WDR5 protein(P61964)(2-334aa), fused to N-terminal His-SUMO tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His&SUMO
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 52.5 kDa
• Protein length: 2-334aa
• AA Sequence: ATEEKKPETEAARAQPTPSSSATQS KPTPVKPNYALKFTLAGHTKAVSSV KFSPNGEWLASSSADKLIKIWGAYD GKFEKTISGHKLGISDVAWSSDSNL LVSASDDKTLKIWDVSSGKCLKTLK GHSNYVFCCNFNPQSNLIVSGSFDE SVRIWDVKTGKCLKTLPAHSDPVSA VHFNRDGSLIVSSSYDGLCRIWDTA SGQCLKTLIDDDNPPVSFVKFSPNG KYILAATLDNTLKLWDYSKGKCLKT YTGHKNEKYCIFANFSVTGGKWIVS GSEDNLVYIWNLQTKEIVQKLQGHT DVVISTACHPTENIIASAALENDKT IKLWKSDC
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: WDR5 WD repeat domain 5 [ Homo sapiens ]
• Official Symbol: WDR5
• Synonyms: WDR5; WD repeat domain 5; WD repeat-containing protein 5; SWD3; Set1c WD40 repeat protein; homolog (S. cerevisiae); WD-repeat protein 5; BMP2-induced 3-kb gene protein; SWD3, Set1c WD40 repeat protein, homolog; BIG-3
• Gene ID: 11091
• mRNA Refseq: NM_017588
• Protein Refseq: NP_060058
• MIM: 609012
• UniProt ID: P61964

Reviews

11/25/2020

Their ability to accommodate the requirements of large-scale experiments and guarantee a reliable supply streamlines my research operations, eliminating any concerns related to potential shortages.

10/10/2020

I am confident that the protein will reliably perform in my assays, providing accurate and reproducible results.

09/25/2017

the manufacturer's supply management capabilities assure a seamless and continuous provision of the WDR5 protein.

Q&As

Can WDR5 play a role in non-cancerous diseases?

Yes, WDR5 has been associated with neurodevelopmental disorders, suggesting a role in non-cancerous diseases as well.

How does WDR5 affect neurodevelopment?

WDR5 regulates the expression of genes critical for neural development, and dysregulation can lead to developmental disorders.

How can WDR5 be used as a diagnostic marker for cancer?

Elevated levels of WDR5 in certain cancers can serve as a diagnostic marker when detected in patient samples.

Are there any clinical trials involving WDR5-targeted therapies?

Yes, there are ongoing clinical trials to test the safety and efficacy of WDR5-targeted therapies in cancer patients.

Is there a connection between WDR5 and autoimmune diseases?

Some studies suggest a potential link between WDR5 and autoimmune diseases, but further research is needed to confirm this association.