Active Recombinant Human Il23R, MIgG2a Fc-tagged
|Product Overview :||The extracellular domain of human IL-23R (NP_653302.2) (Gly24-Asp353) is fused to the N-terminus of the Fc region of mouse IgG2awas expressed in CHO cell|
- Gene Information
- Related Products
|Description :||IL23R (interleukin 23 receptor) is a protein-coding gene. Diseases associated with IL23R include inflammatory bowel disease 17, protection against, and psoriasis, protection against, and among its related super-pathways are STAT3 Pathway and Immune response IL-23 signaling pathway. GO annotations related to this gene include interleukin-23 receptor activity and interleukin-12 receptor binding.|
|Source :||CHO cell|
|Tag :||MIgG2a Fc-tagged|
|Form :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Bio-activity :||Measured by its binding ability in a functional ELISA.|
|Molecular Mass :||64KDa (monomer)|
|AA Sequence :||Gly24-Asp353|
|Endotoxin :||<0.06 eu/μg as determined by lal>0.06>|
|Purity :||>98%, by SDS-PAGE under reducing conditions|
|Stability :||Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.|
|Reconstitution :||Reconstitute at 100μg/ml in sterile PBS.|
|Warning :||Avoid freeze/thaw cycles.|
|Gene Name :||IL23R interleukin 23 receptor [ Homo sapiens ]|
|Official Symbol :||IL23R|
|Synonyms :||IL23R; interleukin 23 receptor; interleukin-23 receptor; IL 23R; IL-23 receptor;|
|Gene ID :||149233|
|mRNA Refseq :||NM_144701|
|Protein Refseq :||NP_653302|
|UniProt ID :||Q5VWK5|
|Chromosome Location :||1p31.2|
|Pathway :||Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;|
|Function :||contributes_to interleukin-12 receptor binding; contributes_to interleukin-23 binding; contributes_to interleukin-23 receptor activity; receptor activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL23R activation promotes Th17 cell differentiation.
IL23R has multiple alternative splicing variants.
IL23R undergoes phosphorylation that affects its stability.
The half-life of IL23R protein in activated T-cells is approximately 48 hours.
MicroRNAs like miR-20a regulate IL23R expression.
IL23R contributes to the release of pro-inflammatory cytokines like IL-17.
IL23R is implicated in autoimmune diseases like Crohn's.
IL23R expression is upregulated during bacterial infection.
IL23R forms heterodimers with IL-12Rβ1.
IL23R activates the JAK-STAT and NF-κB pathways.
Customer Reviews (3)Write a review
High specificity in ELISA. -
Effective in autoimmune models. -
Suitable for receptor binding studies. -
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