Active Recombinant Human Il23R, MIgG2a Fc-tagged

Cat.No. : Il23R-8615H
Product Overview : The extracellular domain of human IL-23R (NP_653302.2) (Gly24-Asp353) is fused to the N-terminus of the Fc region of mouse IgG2awas expressed in CHO cell
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Description : IL23R (interleukin 23 receptor) is a protein-coding gene. Diseases associated with IL23R include inflammatory bowel disease 17, protection against, and psoriasis, protection against, and among its related super-pathways are STAT3 Pathway and Immune response IL-23 signaling pathway. GO annotations related to this gene include interleukin-23 receptor activity and interleukin-12 receptor binding.
Source : CHO cell
Species : Human
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.
Molecular Mass : 64KDa (monomer)
AA Sequence : Gly24-Asp353
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : >98%, by SDS-PAGE under reducing conditions
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : IL23R interleukin 23 receptor [ Homo sapiens ]
Official Symbol : IL23R
Synonyms : IL23R; interleukin 23 receptor; interleukin-23 receptor; IL 23R; IL-23 receptor;
Gene ID : 149233
mRNA Refseq : NM_144701
Protein Refseq : NP_653302
MIM : 607562
UniProt ID : Q5VWK5
Chromosome Location : 1p31.2
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : contributes_to interleukin-12 receptor binding; contributes_to interleukin-23 binding; contributes_to interleukin-23 receptor activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
10/21/2020

    High specificity in ELISA.

    04/28/2016

      Effective in autoimmune models.

      03/30/2016

        Suitable for receptor binding studies.

        Q&As (10)

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        How does IL23R activation affect T-cell differentiation? 12/22/2022

        IL23R activation promotes Th17 cell differentiation.

        Does IL23R have alternative splicing variants? 02/20/2022

        IL23R has multiple alternative splicing variants.

        Does IL23R have any post-translational modifications that affect its stability? 08/23/2021

        IL23R undergoes phosphorylation that affects its stability.

        What is the half-life of IL23R protein in activated T-cells? 08/21/2020

        The half-life of IL23R protein in activated T-cells is approximately 48 hours.

        Are there any microRNAs that regulate IL23R expression? 06/16/2020

        MicroRNAs like miR-20a regulate IL23R expression.

        How does IL23R contribute to cytokine release? 02/15/2019

        IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

        What role does IL23R play in autoimmune diseases? 08/22/2018

        IL23R is implicated in autoimmune diseases like Crohn's.

        How does IL23R expression change during infection? 10/12/2017

        IL23R expression is upregulated during bacterial infection.

        Does IL23R form homodimers or heterodimers? 08/15/2016

        IL23R forms heterodimers with IL-12Rβ1.

        What intracellular pathways are activated by IL23R? 08/06/2016

        IL23R activates the JAK-STAT and NF-κB pathways.

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