Recombinant Human IL23R protein, mFc-tagged

• Cat.No.: IL23R-614H
• Product Overview: Recombinant Human IL-23 R Protein Protein is expressed from mammalian with a mFc at the Ctermina It contains Gly24 - Gly355.

Specification

• Description: Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 . The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
• Source: HEK293
• Species: Human
• Tag: mFc
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The Protein has a calculated MW of 63.7kDa .As a result of glycosylation, the protein migrates to 80-115kDa based on Bis-Tris PAGE.
• Protein length: It contains Gly24 - Gly355.
• Endotoxin: Less than 0.05EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IL23R interleukin 23 receptor [ Homo sapiens ]
• Official Symbol: IL23R
• Synonyms: IBD17; IL-23 R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin-23 receptor
• Gene ID: 149233
• mRNA Refseq: NM_144701
• Protein Refseq: NP_653302
• MIM: 607562
• UniProt ID: Q5VWK5