Recombinant Human IL23R protein, mFc-tagged
|Product Overview :||Recombinant Human IL-23 R Protein Protein is expressed from mammalian with a mFc at the Ctermina It contains Gly24 - Gly355.|
- Gene Information
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|Description :||Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 . The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.|
|Form :||Supplied as 0.22um filtered solution in PBS (pH 7.4).|
|Molecular Mass :||The Protein has a calculated MW of 63.7kDa .As a result of glycosylation, the protein migrates to 80-115kDa based on Bis-Tris PAGE.|
|Protein length :||It contains Gly24 - Gly355.|
|Endotoxin :||Less than 0.05EU per ug by the LAL method.|
|Purity :||> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC|
|Storage :||The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.|
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|Gene Name :||IL23R interleukin 23 receptor [ Homo sapiens ]|
|Official Symbol :||IL23R|
|Synonyms :||IBD17; IL-23 R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin-23 receptor|
|Gene ID :||149233|
|mRNA Refseq :||NM_144701|
|Protein Refseq :||NP_653302|
|UniProt ID :||Q5VWK5|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL23R activation promotes Th17 cell differentiation.
IL23R has multiple alternative splicing variants.
IL23R undergoes phosphorylation that affects its stability.
The half-life of IL23R protein in activated T-cells is approximately 48 hours.
MicroRNAs like miR-20a regulate IL23R expression.
IL23R contributes to the release of pro-inflammatory cytokines like IL-17.
IL23R is implicated in autoimmune diseases like Crohn's.
IL23R expression is upregulated during bacterial infection.
IL23R forms heterodimers with IL-12Rβ1.
IL23R activates the JAK-STAT and NF-κB pathways.
Customer Reviews (3)Write a review
High specificity in ELISA. -
Effective in autoimmune models. -
Suitable for receptor binding studies. -
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