Recombinant Human IL23R protein, mFc-tagged

• Cat.No.: IL23R-614H
• Product Overview: Recombinant Human IL-23 R Protein Protein is expressed from mammalian with a mFc at the Ctermina It contains Gly24 - Gly355.

Specification

• Description: Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 . The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
• Source: HEK293
• Species: Human
• Tag: mFc
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The Protein has a calculated MW of 63.7kDa .As a result of glycosylation, the protein migrates to 80-115kDa based on Bis-Tris PAGE.
• Protein length: It contains Gly24 - Gly355.
• Endotoxin: Less than 0.05EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IL23R interleukin 23 receptor [ Homo sapiens ]
• Official Symbol: IL23R
• Synonyms: IBD17; IL-23 R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin-23 receptor
• Gene ID: 149233
• mRNA Refseq: NM_144701
• Protein Refseq: NP_653302
• MIM: 607562
• UniProt ID: Q5VWK5

Reviews

10/21/2020

High specificity in ELISA.

04/28/2016

Effective in autoimmune models.

03/30/2016

Suitable for receptor binding studies.

Q&As

How does IL23R activation affect T-cell differentiation?

IL23R activation promotes Th17 cell differentiation.

Does IL23R have alternative splicing variants?

IL23R has multiple alternative splicing variants.

Does IL23R have any post-translational modifications that affect its stability?

IL23R undergoes phosphorylation that affects its stability.

What is the half-life of IL23R protein in activated T-cells?

The half-life of IL23R protein in activated T-cells is approximately 48 hours.

Are there any microRNAs that regulate IL23R expression?

MicroRNAs like miR-20a regulate IL23R expression.

How does IL23R contribute to cytokine release?

IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

What role does IL23R play in autoimmune diseases?

IL23R is implicated in autoimmune diseases like Crohn's.

How does IL23R expression change during infection?

IL23R expression is upregulated during bacterial infection.

Does IL23R form homodimers or heterodimers?

IL23R forms heterodimers with IL-12Rβ1.

What intracellular pathways are activated by IL23R?

IL23R activates the JAK-STAT and NF-κB pathways.