Recombinant Human IL23R protein, His-tagged

Cat.No. : IL23R-589H
Product Overview : Recombinant Human IL23R (Gly24-Gly355) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Gly24
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 39.9 kDa. The protein migrates as 55-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Gly24-Gly355
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL23R
Official Symbol : IL23R
Synonyms : IL23R; interleukin 23 receptor; interleukin-23 receptor; IL 23R; IL-23 receptor
Gene ID : 149233
mRNA Refseq : NM_144701
Protein Refseq : NP_653302
MIM : 607562
UniProt ID : Q5VWK5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Customer Reviews (3)

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    High specificity in ELISA.


      Effective in autoimmune models.


        Suitable for receptor binding studies.

        Q&As (10)

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        How does IL23R activation affect T-cell differentiation? 12/22/2022

        IL23R activation promotes Th17 cell differentiation.

        Does IL23R have alternative splicing variants? 02/20/2022

        IL23R has multiple alternative splicing variants.

        Does IL23R have any post-translational modifications that affect its stability? 08/23/2021

        IL23R undergoes phosphorylation that affects its stability.

        What is the half-life of IL23R protein in activated T-cells? 08/21/2020

        The half-life of IL23R protein in activated T-cells is approximately 48 hours.

        Are there any microRNAs that regulate IL23R expression? 06/16/2020

        MicroRNAs like miR-20a regulate IL23R expression.

        How does IL23R contribute to cytokine release? 02/15/2019

        IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

        What role does IL23R play in autoimmune diseases? 08/22/2018

        IL23R is implicated in autoimmune diseases like Crohn's.

        How does IL23R expression change during infection? 10/12/2017

        IL23R expression is upregulated during bacterial infection.

        Does IL23R form homodimers or heterodimers? 08/15/2016

        IL23R forms heterodimers with IL-12Rβ1.

        What intracellular pathways are activated by IL23R? 08/06/2016

        IL23R activates the JAK-STAT and NF-κB pathways.

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