Active Recombinant Mouse Il27, Fc-tagged
Cat.No. : | Il27-351M |
Product Overview : | The mouse IL-27 complex composed of the Ebi3 subunit (aa 1-228) and the p28 subunit (aa 29-234) is fused through a polypeptide linker to the Fc region of human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on na?e CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction. |
Source : | CHO Cells |
Species : | Mouse |
Tag : | Fc |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Bioactivity was measured in a cell proliferation assay of Con A activated mouse splenocytes. |
Purity : | ≥98% (SDS-PAGE) |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles. |
Gene Name : | Il27 interleukin 27 [ Mus musculus ] |
Official Symbol : | Il27 |
Synonyms : | IL27; interleukin 27; interleukin-27 subunit alpha; IL27-A; IL-27-A; interleukin 30; IL-27 p28 subunit; IL-27 subunit alpha; p28; Il30; IL-27; IL-27p28; |
Gene ID : | 246779 |
mRNA Refseq : | NM_145636 |
Protein Refseq : | NP_663611 |
Function : | cytokine activity; interleukin-27 receptor binding; protein binding; receptor binding; |
Products Types
◆ Recombinant Protein | ||
Il27-3518M | Active Recombinant Mouse Il27 Protein | +Inquiry |
IL27-2306H | Recombinant Human IL27 Protein, His-tagged | +Inquiry |
IL27-1033H | Recombinant Human IL27 Protein, His-tagged | +Inquiry |
Il27-1032R | Recombinant Rat Il27 Protein, His-tagged | +Inquiry |
IL27-167M | Recombinant Mouse p28 Subunit (IL-27) Protein | +Inquiry |
◆ Lysates | ||
IL27-001HCL | Recombinant Human IL27 cell lysate | +Inquiry |
IL27-1309MCL | Recombinant Mouse IL27 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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