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Active Recombinant Human IL27, HIgG1 Fc-tagged

Cat.No. : IL27-123H
Product Overview : The human IL-27 complex composed of the Ebi3 subunit(NP_005746.2) (Arg21-Lys229) and the p28 subunit(NP_663634.2)(Val26-Pro243) is fused through a polypeptide linker to the Fc region of human IgG1 was expressed in CHO cell.
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Description : The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein isrelated to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similarto interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but notmemory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferongamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by theclass I cytokine receptor (WSX1/TCRR).
Source : CHO cells
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Bioactivity was measured in a cell proliferation assay using anti-CD3 activated human peripheral mononuclear cells.
Molecular Mass : 78 KDa (monomer)
AA Sequence : The human IL-27 complex composed of the Ebi3 subunit(NP_005746.2) (Arg21-Lys229) and the p28 subunit(NP_663634.2)(Val26-Pro243) is fused through a polypeptide linker to the Fc region of human IgG1.
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : IL27 interleukin 27 [ Homo sapiens ]
Official Symbol : IL27
Synonyms : IL27; interleukin 27;
Gene ID : 144841

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there have current difficulties in the study of Il27? 12/23/2022

The current challenges in the study of Il27 include potential side effects, preparation purity and other challenges.

Which scientific research fields are deeply studying Il27? 02/21/2022

The potential application of Il27 in tumor immunotherapy and autoimmune diseases is being deeply studied in the scientific research field.

Is the production of Il27 related to genetic factors? 09/19/2021

The production of Il27 is related to genetic factors, and the expression level and polymorphism of genes may affect its production and function.

Which role of Il27 in inflammatory diseases? 05/17/2021

Studies have shown that Il27 may have an anti-inflammatory effect in inflammatory diseases, regulating the degree of inflammatory response.

What the potential applications of recombinant Il27 in cancer therapy? 01/30/2021

Current studies have shown that Il27 has potential application value in enhancing anti-tumor immunity and alleviating tumor invasion and metastasis.

What is the effect of Il27 on immune response? 09/27/2020

Il27 can enhance the activation and proliferation of specific immune cells and regulate the intensity and direction of immune response.

Customer Reviews (3)

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Reviews
03/30/2022

    The purity is very high, no impurities.

    08/05/2020

      Biological activity is very strong and can be used in various biological experiments.

      05/30/2019

        Stability is very good, and it will not denaturate at high temperatures.

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