Active Recombinant Rat Cxcl1 Protein

• Cat.No.: Cxcl1-187C
• Product Overview: Recombinant Rat Cxcl1 Protein without tag was expressed in HEK 293.

Specification

• Description: GRO/MGSA/CXCL1 has chemotactic activity for neutrophils. It may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively.
• Source: HEK 293
• Species: Rat
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Bio-activity: Active, measured in a functional assay using HUVEC cells.
• Molecular Mass: ~7.8 kDa, observed by reducing SDS-PAGE.
• AA Sequence: APVANELRCQCLQTVAGIHFKNIQS LKVMPPGPHCTQTEVIATLKNGREA CLDPEAPMVQKIVQKMLKGVPK
• Endotoxin: < 0.2 EU/μg, determined by LAL method.
• Purity: > 95% as analyzed by SDS-PAGE.
• Storage: Lyophilized recombinant Rat GRO/MGSA/CXCL1 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Rat GRO/MGSA/CXCL1 should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
• Storage Buffer: Lyophilized after extensive dialysis against PBS.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Gene Information

• Gene Name: Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Rattus norvegicus ]
• Official Symbol: Cxcl1
• Synonyms: CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); growth-regulated alpha protein; gro; C-X-C motif chemokine 1; cytokine-induced neutrophil chemoattractant 1; platelet-derived growth factor-inducible protein KC; Gro1; CINC-1
• Gene ID: 81503
• mRNA Refseq: NM_030845
• Protein Refseq: NP_110472
• UniProt ID: G3V6C6

Reviews

06/15/2020

Efficient delivery, great service.

01/01/2019

Product as described, perfect.

10/13/2018

Reliable for protein work.

Q&As

Are there any therapeutic strategies targeting CXCL1?

Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

How does CXCL1 contribute to inflammation?

It mediates inflammation by promoting leukocyte migration and activation.

What role does CXCL1 play in tumor progression?

In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

What is the relationship between CXCL1 and angiogenesis?

CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

What is the primary function of CXCL1 in the immune system?

CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

In which pathological conditions is CXCL1 found to be elevated?

CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

How is the expression of CXCL1 regulated in cells?

CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.