Active Recombinant Rat Cxcl1 Protein
|Product Overview :||Recombinant Rat Cxcl1 Protein without tag was expressed in HEK 293.|
- Gene Information
- Related Products
|Description :||GRO/MGSA/CXCL1 has chemotactic activity for neutrophils. It may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively.|
|Source :||HEK 293|
|Form :||Sterile Filtered White lyophilized (freeze-dried) powder.|
|Bio-activity :||Active, measured in a functional assay using HUVEC cells.|
|Molecular Mass :||~7.8 kDa, observed by reducing SDS-PAGE.|
|AA Sequence :||APVANELRCQCLQTVAGIHFKNIQS LKVMPPGPHCTQTEVIATLKNGREA CLDPEAPMVQKIVQKMLKGVPK|
|Endotoxin :||< 0.2 EU/μg, determined by LAL method.|
|Purity :||> 95% as analyzed by SDS-PAGE.|
|Storage :||Lyophilized recombinant Rat GRO/MGSA/CXCL1 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Rat GRO/MGSA/CXCL1 should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.|
|Storage Buffer :||Lyophilized after extensive dialysis against PBS.|
|Reconstitution :||Reconstituted in ddH2O or PBS at 100 μg/mL.|
|Gene Name :||Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Rattus norvegicus ]|
|Official Symbol :||Cxcl1|
|Synonyms :||CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); growth-regulated alpha protein; gro; C-X-C motif chemokine 1; cytokine-induced neutrophil chemoattractant 1; platelet-derived growth factor-inducible protein KC; Gro1; CINC-1;|
|Gene ID :||81503|
|mRNA Refseq :||NM_030845|
|Protein Refseq :||NP_110472|
|UniProt ID :||G3V6C6|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.
It mediates inflammation by promoting leukocyte migration and activation.
In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.
CXCL1 contributes to angiogenesis, supporting new blood vessel formation.
CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.
CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.
CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.
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Efficient delivery, great service. -
Product as described, perfect. -
Reliable for protein work. -
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