Recombinant Human CXCL1 protein, His & GST-tagged

Cat.No. : CXCL1-769H
Product Overview : Recombinant Human CXCL1 aa. (Ala35~Asn107 (Accession # P09341)) fused with N-terminal His & GST tag was produced in E. coli cells.
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Description : This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4.
Source : E. coli
Species : Human
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 40.0kDa
Protein length : Ala35~Asn107 (Accession # P09341)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Characteristic : The isoelectric point is 8.3.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4
Gene Name : CXCL1 C-X-C motif chemokine ligand 1 [ Homo sapiens (human) ]
Official Symbol : CXCL1
Synonyms : CXCL1; C-X-C motif chemokine ligand 1; FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a; growth-regulated alpha protein; C-X-C motif chemokine 1; GRO-alpha(1-73); GRO1 oncogene (melanoma growth stimulating activity, alpha); GRO1 oncogene (melanoma growth-stimulating activity); MGSA alpha; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); fibroblast secretory protein; melanoma growth stimulating activity, alpha; melanoma growth stimulatory activity alpha; neutrophil-activating protein 3
Gene ID : 2919
mRNA Refseq : NM_001511.3
Protein Refseq : NP_001502.1
UniProt ID : P09341

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there any therapeutic strategies targeting CXCL1? 11/17/2022

Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

How does CXCL1 contribute to inflammation? 05/03/2022

It mediates inflammation by promoting leukocyte migration and activation.

What role does CXCL1 play in tumor progression? 09/30/2021

In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

What is the relationship between CXCL1 and angiogenesis? 04/21/2021

CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

What is the primary function of CXCL1 in the immune system? 11/15/2019

CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

In which pathological conditions is CXCL1 found to be elevated? 08/05/2018

CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

How is the expression of CXCL1 regulated in cells? 02/06/2018

CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.

Customer Reviews (3)

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Reviews
06/15/2020

    Efficient delivery, great service.

    01/01/2019

      Product as described, perfect.

      10/13/2018

        Reliable for protein work.

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