Active Recombinant Human Chemokine (C-X-C Motif) Ligand 1, MIgG2a Fc-tagged
| Cat.No. : | CXCL1-222H |
| Product Overview : | The extracellular domain of human CXCL1 (AAH11976.1)(Ala35-Asn107) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell. |
- Specification
- Gene Information
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| Description : | This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4 |
| Source : | CHO cell |
| Species : | Human |
| Tag : | MIgG2a Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | Measured by its ability to induce myeloperoxidase. |
| Molecular Mass : | 34KDa (monomer) |
| AA Sequence : | Ala35-Asn107 |
| Endotoxin : | <0.06 eu/μg as determined by lal> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Gene Name : | CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Homo sapiens ] |
| Official Symbol : | CXCL1 |
| Synonyms : | CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); fibroblast secretory protein , FSP, GRO1, GRO1 oncogene (melanoma growth stimulating activity, alpha) , MGSA; growth-regulated alpha protein; GROa; MGSA a; NAP 3; SCYB1; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrophil-activating protein 3; melanoma growth stimulatory activity alpha; GRO1 oncogene (melanoma growth-stimulating activity); GRO1 oncogene (melanoma growth stimulating activity, alpha); FSP; GRO1; MGSA; NAP-3; MGSA-a; |
| Gene ID : | 2919 |
| mRNA Refseq : | NM_001511 |
| Protein Refseq : | NP_001502 |
| MIM : | 155730 |
| UniProt ID : | P09341 |
| Chromosome Location : | 4q13.3 |
| Pathway : | Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; |
| Function : | chemokine activity; enzyme activator activity; growth factor activity; receptor binding; |
Products Types
| ◆ Recombinant Protein | ||
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| CXCL1-982H | Recombinant Human CXCL1 Protein, His-SUMO-tagged | +Inquiry |
| Cxcl1-032C | Active Recombinant Mouse Cxcl1 Protein (72 aa) | +Inquiry |
| ◆ Native Protein | ||
| CXCL1-27707TH | Native Human CXCL1 | +Inquiry |
| ◆ Lysates | ||
| CXCL1-425HCL | Recombinant Human CXCL1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
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Are there any therapeutic strategies targeting CXCL1?
11/17/2022
Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.
How does CXCL1 contribute to inflammation?
05/03/2022
It mediates inflammation by promoting leukocyte migration and activation.
What role does CXCL1 play in tumor progression?
09/30/2021
In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.
What is the relationship between CXCL1 and angiogenesis?
04/21/2021
CXCL1 contributes to angiogenesis, supporting new blood vessel formation.
What is the primary function of CXCL1 in the immune system?
11/15/2019
CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.
In which pathological conditions is CXCL1 found to be elevated?
08/05/2018
CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.
How is the expression of CXCL1 regulated in cells?
02/06/2018
CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.
Customer Reviews (3)
Write a reviewReviews
06/15/2020
Efficient delivery, great service. -
01/01/2019
Product as described, perfect. -
10/13/2018
Reliable for protein work. -
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