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Recombinant Mouse Cytotoxic And Regulatory T Cell Molecule, Fc-tagged

Cat. No.: Crtam-5613M
Product Overview: Recombinant Mouse Crtamprotein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330 (C-terminus) and Ala17-Ser284 (N-terminus).
Description: Crtam (ClassIrestricted T cellassociated molecule) is a member of the nectin family ofthe immunoglobulin superfamily. It is expressed by activated CD8+ and NK Tcells. NK activation receptor engagement, but not cytokines, also inducesCratm expression on NK cells. Crtam is found in spleen, thymus, smallintestine, peripheral blood, and surprisingly, in brain where it is highlyexpressed by Purkinje cells of the cerebellum.
Source: Murine myeloma cellline, NS0-derived
Form: Lyophilized from a 0.2μm filtered solution in PBS.
N-terminalSequence: Ala17
Molecular Weight: 56.1 kDa
Activity: Measuredby its binding activity in a functional ELISA. Galiberet, L. et al. (2005) J.Biol. Chem. 280:21955. Immobilized rmCrtam/Fc Chimera at 2 μg/mL (100 μL/well)can bind rmIGSF4A with a linear range of 0.15-10 μg/mL
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 90 kDa,reducing conditions
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Crtam cytotoxic and regulatoryT cell molecule [ Mus musculus ]
Official Symbol: Crtam
Synonyms: Crtam; cytotoxicand regulatory T cell molecule; MGC141606, MGC141607; cytotoxic andregulatory T-cell molecule; class I-restricted T cell-associated molecule;class-I MHC-restricted T-cell-associated molecule; CD355
Gene ID: 54698
mRNA Refseq: NM_019465
Protein Refseq: NP_062338
UniProt ID: Q149L7
Chromosome Location: 9 A5.1; 9 20.5 cM
Pathway: Adaptive ImmuneSystem; Immune System; Immunoregulatory interactions between a Lymphoid and anon-Lymphoid cell
Function: protein binding;receptor binding

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