"RIPK3" Related Products

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Recombinant Human RIPK3, GST-tagged, Active

Cat. No.: RIPK3-2758H
Product Overview: Recombinant Human RIPK3 encoding full-lengthhuman RIPK3 produced by baculovirus in Sf9 insect cells, was fused a GST-tag at N-terminal.
Description: RIPK3 is a member of the receptor-interactingprotein (RIP) family of serine/threonine protein kinases, which contains aC-terminal domain unique from other RIP family members. RIPK3 ispredominantly localized to the cytoplasm, and specifically, are colocalizedin the mitochondrion which can undergo nucleocytoplasmic shuttlingdependent on novel nuclear localization and export signals. RIPK3 is acomponent of the tumor necrosis factor (TNF) receptor-I signaling complex, andcan induce apoptosis and weakly activate the NF-kappaB transcription factorand caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis byfunctioning in a proteolytically active complex with CFLAR and that thiscomplex is required for the protective function.
Source: Baculovirus
MolecularWeight: 96 kDa
Formulation: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mMNaCl, 10mM glutathione, 0.1mM EDTA, 0,25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity: >70%
SpecificActivity: 38nM/min/mg
Concentration: 0.05μg / μl
Applications: Kinase Assay, Western Blot
Storage: Storeproduct at –70°C. For optimal storage, aliquot target intosmaller quantities after centrifugation and store at recommended temperature.For most favorable performance, avoid repeated handling and multiplefreeze/thaw cycles.
Gene Name: RIPK3receptor-interacting serine-threonine kinase 3 [ Homo sapiens ]
Official Symbol: RIPK3
Synonyms: RIPK3;receptor-interacting serine-threonine kinase 3; receptor-interactingserine/threonine-protein kinase 3; RIP3; RIP-3; RIP-like protein kinase 3; receptorinteracting protein 3; receptor-interacting protein 3; OTTHUMP00000164791; EC2.7.11.1
Gene ID: 11035
mRNA Refseq: NM_006871
Protein Refseq: NP_006862
MIM: 605817
UniProt ID: Q9Y572
Chromosome Location: 14q12
Pathway: CytosolicDNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensingpathway, conserved biosystem; Immune System, organism-specific biosystem;Innate Immune System, organism-specific biosystem; TNF-alpha/NF-kB SignalingPathway, organism-specific biosystem
Function: ATP binding;NF-kappaB-inducing kinase activity; nucleotide binding; protein binding;protein kinase activity

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