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| Cat. No. : | CED37 |
| Product Overview : | Haemocoagulase is an isolated and purified snake venom enzyme from Bothrops atrox. It is free of any toxic protein substances. |
| Description : | Haemocoagulase contains two different enzymes acting on blood coagulation; one has a thrombin like effect, the other has a thromboplastin like activity. In vitro, Haemocoagulase causes coagulation of fibrinogen by gradually splitting off fibrinopeptide A, giving rise to des-A-fibrin monomers, which polymerise end-to-end to fibrin. In the presence of platelet factor 3 Haemocoagulase activates factor X. In vivo, therapeutic doses of Haemocoagulase will not initiate intravasal coagulation. The des-A-fibrin monomer produced by Haemocoagulase remains in solution because it forms a complex with native fibrinogen. Haemocoagulase accordingly promotes and accelerates the physiological processes of haemostasis. Haemocoagulase shortens the bleeding and coagulation time. |
| Main therapeutic applications : | Haemocoagulase is indicated in all fields of medicine, i.e. gynaecology, urology, gastro-enterology, dentistry for the prevention and treatment of haemorrhages of various origins, including cases where surgical treatment is required. |
| Background : | Bothrops atrox is a venomous pit viper species found in the tropical lowlands of northern South America east of the Andes. No subspecies are currently recognized. |
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