||Haemocoagulase is an isolated and purified snake venom enzyme from Bothrops atrox. It is free of any toxic protein substances.
||Haemocoagulase contains two different enzymes acting on blood coagulation; one has a thrombin like effect, the other has a thromboplastin like activity. In vitro, Haemocoagulase causes coagulation of fibrinogen by gradually splitting off fibrinopeptide A, giving rise to des-A-fibrin monomers, which polymerise end-to-end to fibrin. In the presence of platelet factor 3 Haemocoagulase activates factor X. In vivo, therapeutic doses of Haemocoagulase will not initiate intravasal coagulation. The des-A-fibrin monomer produced by Haemocoagulase remains in solution because it forms a complex with native fibrinogen. Haemocoagulase accordingly promotes and accelerates the physiological processes of haemostasis. Haemocoagulase shortens the bleeding and coagulation time.
|Main therapeutic applications:
||Haemocoagulase is indicated in all fields of medicine, i.e. gynaecology, urology, gastro-enterology, dentistry for the prevention and treatment of haemorrhages of various origins, including cases where surgical treatment is required.
||Bothrops atrox is a venomous pit viper species found in the tropical lowlands of northern South America east of the Andes. No subspecies are currently recognized.