"ASXL1" Related Products


Recombinant Human ASXL1, His-tagged

Cat.No.: ASXL1-9951H
Product Overview: Recombinant Human ASXL1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
Source: E.coli
Species: Human
Tag: His
Protein length: 1-84a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: ASXL1 additional sex combs like 1 (Drosophila) [ Homo sapiens ]
Official Symbol: ASXL1
Synonyms: ASXL1; additional sex combs like 1 (Drosophila); putative Polycomb group protein ASXL1; KIAA0978; additional sex combs-like protein 1; MDS; BOPS; MGC71111; MGC117280;
Gene ID: 171023
mRNA Refseq: NM_001164603
Protein Refseq: NP_001158075
MIM: 612990
UniProt ID: Q8IXJ9
Chromosome Location: 20q11
Function: metal ion binding; protein binding;

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