Recombinant Human FAH, His-tagged
Cat.No. : | FAH-85H |
Product Overview : | Recombinant Human Fumarylacetoacetase/FAH is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Ser2-Ser419) of Human FAH fused with a polyhistidine tag at the C-terminus. |
- Specification
- Gene Information
- Related Products
Description : | Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. Defects in Fumarylacetoacetase cause tyrosinemia type 1, which is congenital metabolism defect characterized by elevated levels of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include renal tubular injury, self-mutilation, hepatic necrosis, episodic weakness, and seizures. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Ser2-Ser419 |
AA Sequence : | MSFIPVAEDSDFPIHNLPYGVFSTR GDPRPRIGVAIGDQILDLSIIKHLF TGPVLSKHQDVFNQP TLNSFMGLGQAAWKEARVFLQNLLS VSQARLRDDTELRKCAFISQASATM HLPATIGDYTDFYSS RQHATNVGIMFRDKENALMPNWLHL PVGYHGRASSVVVSGTPIRRPMGQM KPDDSKPPVYGACKL LDMELEMAFFVGPGNRLGEPIPISK AHEHIFGMVLMNDWSARDIQKWEYV PLGPFLGKSFGTTVS PWVVPMDALMPFAVPNPKQDPRPLP YLCHDEPYTFDINLSVNLKGEGMSQ AATICKSNFKYMYWT MLQQLTHHSVNGCNLRPGDLLASGT ISGPEPENFGSMLELSWKGTKPIDL GNGQTRKFLLDGDEV IITGYCQGDGYRIGFGQCAGKVLPA LLPSVDHHHHHH |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Gene Name : | FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) [ Homo sapiens ] |
Official Symbol : | FAH |
Synonyms : | FAH; fumarylacetoacetate hydrolase (fumarylacetoacetase); fumarylacetoacetase; FAA; beta-diketonase; FLJ51912; |
Gene ID : | 2184 |
mRNA Refseq : | NM_000137 |
Protein Refseq : | NP_000128 |
MIM : | 613871 |
UniProt ID : | P16930 |
Chromosome Location : | 15q23-q25 |
Pathway : | Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Phenylalanine and tyrosine catabolism, organism-specific biosystem; Tyrosine degradation, tyrosine => homogentisate, organism-specific biosystem; Tyrosine degradation, tyrosine => |
Function : | catalytic activity; fumarylacetoacetase activity; fumarylacetoacetase activity; hydrolase activity; metal ion binding; |
Products Types
◆ Recombinant Protein | ||
FAH-1854R | Recombinant Rat FAH Protein, His (Fc)-Avi-tagged | +Inquiry |
Fah-1015M | Recombinant Mouse Fah Protein, MYC/DDK-tagged | +Inquiry |
FAH-1368R | Recombinant Rhesus Macaque FAH Protein, His (Fc)-Avi-tagged | +Inquiry |
FAH-2197R | Recombinant Rat FAH Protein | +Inquiry |
FAH-1543R | Recombinant Rhesus monkey FAH Protein, His-tagged | +Inquiry |
◆ Lysates | ||
FAH-6469HCL | Recombinant Human FAH 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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