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Recombinant Human EPHB4, C13&N15-labeled

Cat.No.: EPHB4-231H
Product Overview: Recombinant Human EPHB4 MS Standard Protein, C13 and N15-labeled (EPHB4, Heavy Labeled) Glu 17 - Ala 539 (Accession # NP_004435.3) was produced in human 293 cells (HEK293).
Description: Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. (1) EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.
Source: HEK293
Species: Human
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: EPHB4, Heavy Labeled, fused with 6×His tag at the C-terminus, has a calculated MW of 57.8 kDa. The predicted N-terminus is Glu 17. DTT-reduced Protein migrates as 65-70 kDa due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the EPHB4, Heavy Labeled by the LAL method.
Purity: >97% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC-8oC); After reconstitution under sterile conditions for 1 month (4oC-8oC) or 3 months (-20oC to -70oC).
Gene Name: EPHB4 EPH receptor B4 [ Homo sapiens ]
Official Symbol: EPHB4
Synonyms: EPHB4; EPH receptor B4; EphB4 , HTK; ephrin type-B receptor 4; Tyro11; ephrin receptor EphB4; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; hepatoma transmembrane kinase; tyrosine-protein kinase TYRO11; tyrosine-protein kinase receptor HTK; HTK; MYK1; TYRO11;
Gene ID: 2050
mRNA Refseq: NM_004444
Protein Refseq: NP_004435
MIM: 600011
UniProt ID: P54760
Chromosome Location: 7q22
Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; EPHB forward signaling, organism-specific biosystem; Ephrin B reverse signaling, organism-specific biosystem; EphrinB-EPHB pathway, organism-specific biosystem;
Function: ATP binding; ephrin receptor activity; ephrin receptor activity; nucleotide binding; protein binding; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity;

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