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Native rabbit ACT

Cat.No. : ACT-161R
  • Specification
  • Gene Information
  • Related Products
Description : Protein standard for immunoblotting, immunization and immunoassays.
Source : rabbit muscle
Species : Rabbit
Form : lyophilized, purified
Molecular Mass : 43 Kd
Purity : >98%
Storage : At 2-8 centigrade (lyoph.); at -20 centigrade (reconstituted)
Reconstitution : Reconstitute with 250 ul distilled water (final volume 250 ul)

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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What are the two major components of the bio-functional toxin molecule of ACT? 11/02/2022

The bio-functional toxin molecule of ACT consists of an N-terminal ~400-residue-long adenylate cyclase (AC) enzyme domain and a C-terminal ~1300-residue-long hemolytic activity.

Through which signal pathway is the innate immune response regulated by ACT? 05/15/2022

The findings suggest that ACT may regulate the innate immune response through a signal pathway mediated by Toll-Like Receptor (TLR), particularly TLR4.

What is ACT in the context of whooping cough? 05/11/2022

ACT stands for adenylate cyclase toxin, which is a virulence factor produced by the pathogen Bordetella pertussis, the causative agent of whooping cough

What are some characteristics of the RTX family of bacterial cytolysins? 04/30/2022

The RTX family of bacterial cytolysins is characterized by the presence of calcium-binding repeats and the ability to cause lysis of host cells

What potential implications could arise from the recombinant ACT protein and its functional assays in future studies? 02/23/2022

The availability of the recombinant ACT protein and the established functional assays provide a foundation for future studies on ACT. These tools can be used to investigate the protein's interactions, its impact on immune pathways, and its potential as a therapeutic target for whooping cough or other related conditions.

What are the two major domains of the ACT protein? 01/25/2022

The ACT protein consists of an N-terminal adenylate cyclase (AC) enzyme domain and a C-terminal hemolytic activity domain.

How does ACT affect the secretion of specific cytokines in mice peritoneal macrophages? 03/12/2021

ACT can inhibit the secretion of IL-12 and TNFα induced by LPS in mice peritoneal macrophages, while enhancing the secretion of IL-10.

What are the two important roles of ACT in bacteria colonization and pathogenesis? 03/17/2020

ACT plays important roles in bacteria colonization and pathogenesis by producing pertussis toxin and adenylate cyclase toxin during the invasion of the host.

What is the status of the testing method for ACT content in pertussis vaccine manufacturing in China? 12/10/2019

According to the provided information, the relevant testing method for ACT content is currently unavailable in China.

What is the current understanding of ACT's role in immune regulation during the invasion of the host? 12/01/2019

While previous studies have shown that ACT is involved in immune regulation during the invasion of the host, the exact mechanism is still unclear.

What is the potential significance of previous studies on ACT and its interacting protein TIRAP? 10/02/2019

Previous studies on ACT and its interacting protein TIRAP may provide insights into the specific mechanism by which ACT influences the immune response.

How does the presence of glycine- and aspartate-rich nonapeptide repeats in ACT contribute to its function? 09/20/2019

The glycine- and aspartate-rich nonapeptide repeats found in ACT are characteristic of the RTX family of bacterial cytolysins. These repeats may play a role in the folding, stability, or function of the protein.

Are there any known three-dimensional structural details of the ACT protein? 03/27/2019

The provided information does not mention specific details about the three-dimensional structure of the ACT protein. 

What is the function of the N-terminal AC domain of the ACT protein? 03/21/2019

The N-terminal AC domain of the ACT protein exhibits adenylate cyclase activity, converting ATP into cyclic AMP (cAMP).

How does the hemolytic domain of the ACT protein contribute to its pathogenicity? 03/15/2019

The hemolytic domain of the ACT protein plays a role in the pathogenicity of ACT by causing the destruction of red blood cells. This hemolytic activity can lead to tissue damage and facilitate bacterial colonization and pathogenesis.

To which family of bacterial cytolysins does ACT belong? 04/06/2018

ACT belongs to the RTX (repeat in toxin) family of bacterial cytolysins.

Can you provide more information about the structure of the ACT protein? 08/01/2017

The ACT protein consists of an N-terminal adenylate cyclase (AC) enzyme domain and a C-terminal hemolytic activity domain. It also possesses glycine- and aspartate-rich nonapeptide repeats, which are characteristic of the RTX family of bacterial cytolysins.

What is the function of the C-terminal domain of the ACT protein? 02/21/2017

The C-terminal domain of the ACT protein is responsible for its hemolytic activity, which causes the destruction of red blood cells.

Why is it recommended to monitor the ACT content in the manufacturing process of pertussis vaccine according to the European Pharmacopoeia (EP)? 09/06/2016

Monitoring the ACT content in pertussis vaccine manufacturing ensures quality control and effectiveness of the vaccine. The European Pharmacopoeia (EP) provides guidelines for this monitoring process.

Which family of bacterial cytolysins does ACT belong to? 01/17/2016

ACT belongs to the RTX (repeat in toxin) family of bacterial cytolysins. It possesses a series of glycine- and aspartate-rich nonapeptide repeats.

Customer Reviews (5)

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Reviews
11/07/2018

    The ACT protein effectively facilitated the desired biological response in my study, validating its efficacy and performance.

    10/23/2018

      The protein product had a pleasant odor-free experience during handling, ensuring a comfortable and hassle-free experiment

      06/29/2018

        I obtained robust and statistically significant results using the protein product, indicating its reliability and functionality

        03/09/2018

          The protein product exhibited exceptional stability, remaining active and retaining its functionality throughout my experiments

          03/29/2016

            It yielded reproducible and reliable results, confirming high quality.

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